Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth.

Autor: Costantino L; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy., Ferrari S; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy., Santucci M; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy., Salo-Ahen OMH; Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies, Heidelberg, Germany., Carosati E; Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy., Franchini S; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy., Lauriola A; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy., Pozzi C; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy., Trande M; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy., Gozzi G; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy., Saxena P; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy., Cannazza G; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy., Losi L; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy., Cardinale D; Respiratory, Critical Care & Anesthesia UCL Great Ormond Street Institute of Child Health, London, United Kingdom., Venturelli A; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy., Quotadamo A; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy., Linciano P; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy., Tagliazucchi L; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy., Moschella MG; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.; Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy, Modena, Italy., Guerrini R; Department of Chemical and Pharmaceutical Science, University of Ferrara, Ferrara, Italy., Pacifico S; Department of Chemical and Pharmaceutical Science, University of Ferrara, Ferrara, Italy., Luciani R; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy., Genovese F; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy., Henrich S; Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies, Heidelberg, Germany., Alboni S; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy., Santarem N; IBMC I3S, Porto, Portugal., da Silva Cordeiro A; IBMC I3S, Porto, Portugal.; Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal., Giovannetti E; Department of Medical Oncology, Amsterdam University Medical Center, Cancer Center Amsterdam, 1081HV, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.; CancerPharmacology Lab, Fondazione Pisana per la Scienza, Pisa, Italy., Peters GJ; Department of Medical Oncology, Amsterdam University Medical Center, Cancer Center Amsterdam, 1081HV, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Pinton P; Dept. of Medical Sciences and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy., Rimessi A; Dept. of Medical Sciences and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy., Cruciani G; Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy., Stroud RM; Biochemistry and Biophysics Department, University of California San Francisco, San Francisco, United States., Wade RC; Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies, Heidelberg, Germany.; Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Heidelberg, Germany.; Center for Molecular Biology (ZMBH), DKFZ-ZMBH Alliance, Heidelberg University, Heidelberg, Germany., Mangani S; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy., Marverti G; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy., D'Arca D; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy., Ponterini G; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy., Costi MP; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Publikováno v: ELife [Elife] 2022 Dec 07; Vol. 11. Date of Electronic Publication: 2022 Dec 07.