The use of the CRISPR-Cas9 system and iPSC-derived neurons with a SNCA mutation to model neurodegeneration

Autor: Mosaku, Olukunbi Eniola

Parkinson's disease (PD) is characterised by the selective loss of dopaminergic neurons of the substantia nigra pars compacta. Patients suffer from a progressive motor disorder, defined by the presence of rigidity, resting tremor and bradykinesia. Cu

Externí odkaz: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.763338

Mouse decellularised liver scaffold improves human embryonic and induced pluripotent stem cells differentiation into hepatocyte-like cells

Autor: Lorvellec, Maëlle, Scottoni, Federico, Crowley, Claire, Fiadeiro, Rebeca, Maghsoudlou, Panagiotis, Pellegata, Alessandro Filippo, Mazzacuva, Francesca, Gjinovci, Asllan, Lyne, Anne-Marie, Zulini, Justine, Little, Daniel, Mosaku, Olukunbi, Kelly, Deirdre, De Coppi, Paolo, Gissen, Paul

Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 12, p e0189586 (2017)

Liver transplantation is the definitive treatment of liver failure but donor organ shortage limits its availability. Stem cells are highly expandable and have the potential to differentiate into any specialist cell. Use of patient-derived induced Plu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c297e1569a84319bf5b4e30771d7330d
http://europepmc.org/articles/PMC5738056

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Seeding Induced Pluripotent Stem Cell-Derived Neurons onto 384-Well Plates.

Autor: Little D; MRC Laboratory for Molecular Cell Biology, University College London, London, UK. d.little@ucl.ac.uk., Luft C; MRC Laboratory for Molecular Cell Biology, University College London, London, UK., Pezzini-Picart O; MRC Laboratory for Molecular Cell Biology, University College London, London, UK., Mosaku O; MRC Laboratory for Molecular Cell Biology, University College London, London, UK., Ketteler R; MRC Laboratory for Molecular Cell Biology, University College London, London, UK., Devine MJ; MRC Laboratory for Molecular Cell Biology, University College London, London, UK., Gissen P; MRC Laboratory for Molecular Cell Biology, University College London, London, UK.; Great Ormond Street Institute of Child Health, University College London, London, UK.; NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2019; Vol. 1994, pp. 159-164.

High-Content Analysis of Mitochondrial Function in iPSC-Derived Neurons.

Autor: Little D; MRC Laboratory for Molecular Cell Biology, University College London, London, UK. d.little@ucl.ac.uk., Luft C; MRC Laboratory for Molecular Cell Biology, University College London, London, UK., Mosaku O; MRC Laboratory for Molecular Cell Biology, University College London, London, UK., Ketteler R; MRC Laboratory for Molecular Cell Biology, University College London, London, UK., Devine MJ; MRC Laboratory for Molecular Cell Biology, University College London, London, UK., Gissen P; MRC Laboratory for Molecular Cell Biology, University College London, London, UK.; Great Ormond Street Institute of Child Health, University College London, London, UK.; NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2019; Vol. 1994, pp. 175-184.