Genome-wide identification of fitness-genes in aminoglycoside-resistant Escherichia coli during antibiotic stress

Autor: Sandra Marina Wellner, Mosaed Saleh A. Alobaidallah, Xiao Fei, Ana Herrero-Fresno, John Elmerdahl Olsen

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)

Abstract Resistance against aminoglycosides is widespread in bacteria. This study aimed to identify genes that are important for growth of E. coli during aminoglycoside exposure, since such genes may be targeted to re-sensitize resistant E. coli to t

Externí odkaz: https://doaj.org/article/8f52fb8b5ec34a1487a9ad1435a64d01

Uncovering the Important Genetic Factors for Growth during Cefotaxime-Gentamicin Combination Treatment in blaCTX-M-1 Encoding Escherichia coli

Autor: Mosaed Saleh A. Alobaidallah, Vanesa García, Richard De Mets, Sandra M. Wellner, Line E. Thomsen, Ana Herrero-Fresno, John Elmerdahl Olsen

Publikováno v: Antibiotics, Vol 12, Iss 6, p 993 (2023)

Due to the rapid spread of CTX-M type ESBLs, the rate of resistance to third-generation cephalosporin has increased among Gram-negative bacteria, especially in Escherichia coli, and there is a need to find ways to re-sensitize ESBL E. coli to cephalo

Externí odkaz: https://doaj.org/article/9fb2d7b1a3714d9c96d128dc3d1c9289

Genome-wide analysis of fitness factors in uropathogenic Escherichia coli in a pig urinary tract infection model

Autor: Vanesa García, Kristian Stærk, Mosaed Saleh A. Alobaidallah, Rasmus B. Grønnemose, Priscila R. Guerra, Thomas E. Andersen, John E. Olsen, Ana Herrero-Fresno

Publikováno v: García, V, Stærk, K, Alobaidallah, M S A, Grønnemose, R B, Guerra, P R, Andersen, T E, Olsen, J E & Herrero-Fresno, A 2022, ' Genome-wide analysis of fitness factors in uropathogenic Escherichia coli in a pig urinary tract infection model ', Microbiological Research, vol. 265, pp. 127202 . https://doi.org/10.1016/j.micres.2022.127202
García, V, Stærk, K, Alobaidallah, M S A, Grønnemose, R B, Guerra, P R, Andersen, T E, Olsen, J E & Herrero-Fresno, A 2022, ' Genome-wide analysis of fitness factors in uropathogenic Escherichia coli in a pig urinary tract infection model ', Microbiological Research, vol. 265, 127202 . https://doi.org/10.1016/j.micres.2022.127202

Uropathogenic Escherichia coli (UPEC) is the primary cause of urinary tract infections (UTIs) in animals and humans. We applied Transposon-Directed Insertion Site sequencing (TraDIS) to determine the fitness genes in two well-characterized UPEC strai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65899459067e1fddcaaf64fc966536ae
https://doi.org/10.1016/j.micres.2022.127202