Potential Impact of the Multi-Target Drug Approach in the Treatment of Some Complex Diseases

Autor: Makhoba XH, Viegas Jr C, Mosa RA, Viegas FPD, Pooe OJ

Publikováno v: Drug Design, Development and Therapy, Vol Volume 14, Pp 3235-3249 (2020)

Xolani H Makhoba,1 Claudio Viegas Jr,2 Rebamang A Mosa,1 Flávia PD Viegas,2 Ofentse J Pooe3 1Department of Biochemistry, Genetics and Microbiology, Division of Biochemistry, University of Pretoria, Hatfield, South Africa; 2Laboratory of Research in

Externí odkaz: https://doaj.org/article/9817c2ef058d4755a509562a63eb20a4

The antibacterial activities of some plant-derived triterpenes

Autor: Penduka, D, Gasa, NP, Hlongwane, MS, Mosa, RA, Osunsanmi, FO, Opoku, AR

Publikováno v: African Journal of Traditional, Complementary and Alternative Medicines; Vol 12, No 6 (2015); 180-188

Background: The increase in the prevalence of multi-drug resistant bacteria has necessitated the search for new antimicrobials from alternative sources such as traditional medicinal plants.Materials and Methods: The agar well diffusion method was emp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=78975075580c::a1c7823d826c0a4f748f453317daeee5
https://www.ajol.info/index.php/ajtcam/article/view/125282

In Vitro Antioxidant and In Silico Evaluation of the Anti-β-Lactamase Potential of the Extracts of Cylindrospermum alatosporum NR125682 and Loriellopsis cavenicola NR117881.

Autor: Ikhane AO; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa., Sithole SZ; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa., Cele ND; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa., Osunsanmi FO; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa., Mosa RA; Department of Biochemistry, Genetics and Microbiology, University of Pretoria, Hatfield 0028, South Africa., Opoku AR; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa.

Publikováno v: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2024 May 16; Vol. 13 (5). Date of Electronic Publication: 2024 May 16.

Isolation and Characterization of Potential Lignin Peroxidase-Producing Bacteria from Compost Samples at Richards Bay (South Africa).

Autor: Dube SL; 1Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, South Africa., Osunsanmi FO; 1Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, South Africa., Ngcobo BP; 1Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, South Africa., Mkhwanazi LB; 1Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, South Africa., Jobe ZZ; 1Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, South Africa., Aruleba RT; 2Department of Molecular and Cell Biology, Faculty of Science, University of Cape Town, Cape Town, South Africa., Mosa RA; 3Department of Biochemistry, Genetics and Microbiology, University of Pretoria, Hatfield, South Africa., Opoku AR; 1Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, South Africa.

Publikováno v: Polish journal of microbiology [Pol J Microbiol] 2023 Jun 14; Vol. 72 (2), pp. 117-124. Date of Electronic Publication: 2023 Jun 14 (Print Publication: 2023).

The triterpene, methyl-3β-hydroxylanosta-9,24-dien-21-oate (RA3), attenuates high glucose-induced oxidative damage and apoptosis by improving energy metabolism.

Autor: Sangweni NF; Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council, Tygerberg 7505, South Africa; Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa. Electronic address: nonhlakanipho.sangweni@mrc.ac.za., Mosa RA; Department of Biochemistry, Genetics and Microbiology (BGM), Division of Biochemistry, University of Pretoria, Hatfield 0028, South Africa., Dludla PV; Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council, Tygerberg 7505, South Africa; Department of Life and Environmental Sciences, Polytechnic University of Marche, Ancona 60131, Italy. Electronic address: phiwayinkosi.dludla@mrc.ac.za., Kappo AP; Department of Biochemistry, Faculty of Science, University of Johannesburg, Auckland Park 2006, South Africa., Opoku AR; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa., Muller CJF; Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council, Tygerberg 7505, South Africa; Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa; Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, South Africa. Electronic address: christo.muller@mrc.ac.za., Johnson R; Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council, Tygerberg 7505, South Africa; Division of Medical Physiology, Faculty of Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa. Electronic address: rabia.johnson@mrc.ac.za.

Publikováno v: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 May; Vol. 85, pp. 153546. Date of Electronic Publication: 2021 Mar 10.