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Mitochondrial impairment and intracellular reactive oxygen species alter primary cilia morphology

Autor: Moruzzi, N., Valladolid-Acebes, I., Kannabiran, S.A., Bulgaro, S., Burtscher, I., Leibiger, B., Leibiger, I.B., Berggren, P.O., Brismar, K.

Publikováno v: Life Sci. All. 5:e202201505 (2022)

Primary cilia have recently emerged as cellular signaling organelles. Their homeostasis and function require a high amount of energy. However, how energy depletion and mitochondria impairment affect cilia have barely been addressed. We first studied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::049f9921ae9b6b29123defbd4b435ffe
https://pubmed.ncbi.nlm.nih.gov/36104081

Novel aspects of intra-islet communication: Primary cilia and filopodia.

Autor: Moruzzi N; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital, 171 76, Stockholm, Sweden. Electronic address: noah.moruzzi@ki.se., Leibiger B; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital, 171 76, Stockholm, Sweden., Barker CJ; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital, 171 76, Stockholm, Sweden., Leibiger IB; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital, 171 76, Stockholm, Sweden., Berggren PO; The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Karolinska University Hospital, 171 76, Stockholm, Sweden. Electronic address: Per-olof.berggren@ki.se.

Publikováno v: Advances in biological regulation [Adv Biol Regul] 2023 Jan; Vol. 87, pp. 100919. Date of Electronic Publication: 2022 Oct 04.

Enhanced metabolism and negative regulation of ER stress support higher erythropoietin production in HEK293 cells.

Autor: Saghaleyni R; Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden., Malm M; KTH - Royal Institute of Technology, School of Engineering Sciences in Chemistry, Biotechnology, and Health, Department of Protein Science, 106 91 Stockholm, Sweden., Moruzzi N; The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska Institute, 17176 Stockholm, Sweden., Zrimec J; Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden., Razavi R; KTH - Royal Institute of Technology, School of Engineering Sciences in Chemistry, Biotechnology, and Health, Department of Protein Science, 106 91 Stockholm, Sweden., Wistbacka N; KTH - Royal Institute of Technology, School of Engineering Sciences in Chemistry, Biotechnology, and Health, Department of Protein Science, 106 91 Stockholm, Sweden., Thorell H; KTH - Royal Institute of Technology, School of Engineering Sciences in Chemistry, Biotechnology, and Health, Department of Protein Science, 106 91 Stockholm, Sweden., Pintar A; KTH - Royal Institute of Technology, School of Engineering Sciences in Chemistry, Biotechnology, and Health, Department of Protein Science, 106 91 Stockholm, Sweden., Hober A; Science for Life Laboratory, KTH - Royal Institute of Technology, 171 65 Solna, Sweden., Edfors F; Science for Life Laboratory, KTH - Royal Institute of Technology, 171 65 Solna, Sweden., Chotteau V; KTH - Royal Institute of Technology, School of Engineering Sciences in Chemistry, Biotechnology, and Health, Department of Industrial Biotechnology, 106 91 Stockholm, Sweden., Berggren PO; The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska Institute, 17176 Stockholm, Sweden., Grassi L; Cell Culture & Fermentation Sciences, BioPharmaceutical Development, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Zelezniak A; Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden., Svensson T; Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden; Department of Biology and Biological Engineering, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Chalmers University of Technology, Kemivägen 10, 41258 Gothenburg, Sweden., Hatton D; Cell Culture & Fermentation Sciences, BioPharmaceutical Development, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Nielsen J; Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800 Kongens Lyngby, Denmark., Robinson JL; Department of Biology and Biological Engineering, Chalmers University of Technology, 412 96 Gothenburg, Sweden; Department of Biology and Biological Engineering, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Chalmers University of Technology, Kemivägen 10, 41258 Gothenburg, Sweden. Electronic address: jonrob@chalmers.se., Rockberg J; KTH - Royal Institute of Technology, School of Engineering Sciences in Chemistry, Biotechnology, and Health, Department of Protein Science, 106 91 Stockholm, Sweden. Electronic address: johan.rockberg@biotech.kth.se.

Publikováno v: Cell reports [Cell Rep] 2022 Jun 14; Vol. 39 (11), pp. 110936.

An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation.

Autor: Sabatier P; Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, 17177, Sweden., Beusch CM; Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, 17177, Sweden., Saei AA; Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, 17177, Sweden.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Aoun M; Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, 17177, Sweden., Moruzzi N; The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, 17176, Sweden., Coelho A; Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, 17177, Sweden., Leijten N; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, Utrecht, 3584 CH, The Netherlands., Nordenskjöld M; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, 171 76, Sweden.; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, 17177, Sweden.; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, 171 76, Sweden., Micke P; Immunology, Genetics and Pathology, Rudbecklaboratoriet, Uppsala University, Uppsala, 751 85, Sweden., Maltseva D; Faculty of biology and biotechnology, National Research University Higher School of Economics, Myasnitskaya Street, 13/4, Moscow, 117997, Russia., Tonevitsky AG; Faculty of biology and biotechnology, National Research University Higher School of Economics, Myasnitskaya Street, 13/4, Moscow, 117997, Russia.; Scientific Research Center Bioclinicum, Ugreshskaya str. 2/85, Moscow, 115088, Russia., Millischer V; Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, 17177, Sweden.; Translational Psychiatry, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, 171 76, Sweden.; Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, 1090, Austria., Carlos Villaescusa J; Neurogenetic Unit, Department of Molecular Medicine and Surgery, Karolinska University Hospital, Stockholm, 171 76, Sweden.; Stem Cell R&D-TRU, Novo Nordisk A/S, Måløv, Denmark., Kadekar S; Department of Surgical Sciences, Uppsala University, Uppsala, 752 37, Sweden., Gaetani M; Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, 17177, Sweden.; Chemical Proteomics Core Facility, Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, 171 77, Sweden.; Chemical Proteomics, Science for Life Laboratory (SciLifeLab), Stockholm, 17 177, Sweden., Altynbekova K; geneXplain GmbH, Am Exer 19B, 38302, Wolfenbuettel, Germany., Kel A; geneXplain GmbH, Am Exer 19B, 38302, Wolfenbuettel, Germany., Berggren PO; The Rolf Luft Research Center for Diabetes and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, 17176, Sweden., Simonson O; Department of Surgical Sciences, Uppsala University, Uppsala, 752 37, Sweden.; Department of Cardio-thoracic Surgery and Anesthesiology, Uppsala University Hospital, Uppsala, 751 85, Sweden., Grinnemo KH; Department of Surgical Sciences, Uppsala University, Uppsala, 752 37, Sweden.; Department of Cardio-thoracic Surgery and Anesthesiology, Uppsala University Hospital, Uppsala, 751 85, Sweden., Holmdahl R; Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, 17177, Sweden., Rodin S; Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, 17177, Sweden. sergey.rodin@surgsci.uu.se.; Department of Surgical Sciences, Uppsala University, Uppsala, 752 37, Sweden. sergey.rodin@surgsci.uu.se.; Department of Cardio-thoracic Surgery and Anesthesiology, Uppsala University Hospital, Uppsala, 751 85, Sweden. sergey.rodin@surgsci.uu.se., Zubarev RA; Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, 17177, Sweden. roman.zubarev@ki.se.; Department of Pharmacological & Technological Chemistry, I.M. Sechenov First Moscow State Medical University, Moscow, 119146, Russia. roman.zubarev@ki.se.; The National Medical Research Center for Endocrinology, Moscow, 115478, Russia. roman.zubarev@ki.se.

Publikováno v: Nature communications [Nat Commun] 2021 Nov 12; Vol. 12 (1), pp. 6558. Date of Electronic Publication: 2021 Nov 12.