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pro vyhledávání: '"Morton AJ"'
Autor:
Morton, AJ
Acute toxic models of Huntington’s disease (HD) and Parkinson’s disease (PD) have been used extensively to study neuropathology and behaviour in rodents and non-human primates, but not large animals. We have created an acute quinolinic acid (QA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51fe3d3b38fe749fd1a652e05acf24a
Autor:
Morton, AJ
Response inhibition is a behavioural skill that is important for flexible behaviour and appropriate decision making. It requires the suppression of a prepotent, but inappropriate action, in order to achieve a more advantageous outcome. Response inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::961daab2c413e09e785c71f1d3027e05
Self-propagating, amyloidogenic mutant huntingtin (HTT) aggregates may drive progression of Huntington’s disease (HD). Here, we report the development of a FRET-based HTT aggregate seeding (FRASE) biosensor assay that enables the quantification of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5a514833353b9861994634cd1e609a
Publikováno v:
Human Molecular Genetics
Circadian deficits in Huntington’s disease (HD) are recapitulated in both fragment (R6/2) and full-length (Q175) mouse models of HD. Circadian rhythms are regulated by the suprachiasmatic nuclei (SCN) in the hypothalamus, which are primarily entrai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e449f701c66775a2c3b4555dbc27b410
http://europepmc.org/articles/PMC5418835
http://europepmc.org/articles/PMC5418835
Autor:
McBride, SD, Morton, AJ
Cognitive probes are increasingly being used as an inferred measure of the emotional (and thus welfare) status of the animal. This reflects the bidirectional and interactive nature of emotional and cognitive systems. To date, cognitive paradigms have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f01ba3c0c187d61970122e6e8463fc1
Autor:
Morton, AJ, Kielar, Catherine
The threshold of CAG repeat expansion in the HTT gene that causes HD is 36 CAG repeats, although ‘superlong’ expansions are found in individual neurons in post mortem brains. Previously, we showed that, compared to mice with 440) CAG repeat expan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbaf5a2842681165c08a82ab93f4e9e
https://www.repository.cam.ac.uk/handle/1810/274812
https://www.repository.cam.ac.uk/handle/1810/274812
Autor:
Skene, Debra, Middleton, Benita, Fraser, CK, Pennings, JLA, Kuchel, TR, Rudiger, SR, Bawden, CS, Morton, AJ
The pronounced cachexia (unexplained wasting) seen in Huntington’s disease (HD) patients suggests that metabolic dysregulation plays a role in HD pathogenesis, although evidence of metabolic abnormalities in HD patients is inconsistent. We performe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d598757a7dff252bf572d94a1c0b3b1d
https://www.repository.cam.ac.uk/handle/1810/263354
https://www.repository.cam.ac.uk/handle/1810/263354
Autor:
McLennan, KM, Skillings, EA, Rebelo, CJB, Corke, MJ, Pires Moreira, MA, Morton, AJ, Constantino-Casas, F
The welfare of an individual can be assessed by monitoring behavioural changes, such as inactivity, that may indicate injury or disease. In this study we validated the Actiwatch Mini® activity monitor (AM) for automatic recording of behavioural acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______109::fea068fda10aeeec109e4fccf095a2ca
https://www.repository.cam.ac.uk/handle/1810/248112
https://www.repository.cam.ac.uk/handle/1810/248112
Autor:
Anthony P. Davenport, Morton Aj
Publikováno v:
Brain research. 554(1-2)
Binding sites for iodinated endothelin (ET)-2, ET-3 and vasoactive intestinal contractor (VIC) were visualised in the adult rat brain using quantitative autoradiography and have a similar anatomical distribution to that of ET-1 and sarafotoxin S6b. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75175dd6cb99d78e8cc17bf9f8502d6
https://pubmed.ncbi.nlm.nih.gov/1657290
https://pubmed.ncbi.nlm.nih.gov/1657290
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