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Structure-Activity Relationship Studies of a Series of Semisynthetic Lipopeptides Leading to the Discovery of Surotomycin, a Novel Cyclic Lipopeptide Being Developed for the Treatment of Clostridium difficile-Associated Diarrhea.

Autor: Yin N; †Merck and Co., Inc., Kenilworth, New Jersey 07033, United States., Li J; †Merck and Co., Inc., Kenilworth, New Jersey 07033, United States., He Y; †Merck and Co., Inc., Kenilworth, New Jersey 07033, United States., Herradura P; †Merck and Co., Inc., Kenilworth, New Jersey 07033, United States., Pearson A; †Merck and Co., Inc., Kenilworth, New Jersey 07033, United States., Mesleh MF; †Merck and Co., Inc., Kenilworth, New Jersey 07033, United States., Mascio CT; †Merck and Co., Inc., Kenilworth, New Jersey 07033, United States., Howland K; †Merck and Co., Inc., Kenilworth, New Jersey 07033, United States., Steenbergen J; †Merck and Co., Inc., Kenilworth, New Jersey 07033, United States., Thorne GM; †Merck and Co., Inc., Kenilworth, New Jersey 07033, United States., Citron D; ‡R.M. Alden Research Lab, 6133 Bristol Parkway Ste 175, Culver City, California 90230, United States., Van Praagh AD; †Merck and Co., Inc., Kenilworth, New Jersey 07033, United States., Mortin LI; †Merck and Co., Inc., Kenilworth, New Jersey 07033, United States., Keith D; †Merck and Co., Inc., Kenilworth, New Jersey 07033, United States., Silverman J; †Merck and Co., Inc., Kenilworth, New Jersey 07033, United States., Metcalf C; †Merck and Co., Inc., Kenilworth, New Jersey 07033, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2015 Jun 25; Vol. 58 (12), pp. 5137-42. Date of Electronic Publication: 2015 Jun 03.

In vitro and in vivo characterization of CB-183,315, a novel lipopeptide antibiotic for treatment of Clostridium difficile.

Autor: Mascio CT; Cubist Pharmaceuticals, Inc., Lexington, Massachusetts, USA. carmela.mascio@cubist.com, Mortin LI, Howland KT, Van Praagh AD, Zhang S, Arya A, Chuong CL, Kang C, Li T, Silverman JA

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2012 Oct; Vol. 56 (10), pp. 5023-30. Date of Electronic Publication: 2012 Jul 16.

Rapid bactericidal activity of daptomycin against methicillin-resistant and methicillin-susceptible Staphylococcus aureus peritonitis in mice as measured with bioluminescent bacteria.

Autor: Mortin LI; Cubist Pharmaceuticals Inc, Lexington, MA 02421, USA. Lawrence.Mortin@cubist.com, Li T, Van Praagh AD, Zhang S, Zhang XX, Alder JD

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2007 May; Vol. 51 (5), pp. 1787-94. Date of Electronic Publication: 2007 Feb 16.