Zobrazeno 1 - 10
of 386
pro vyhledávání: '"Mortimer, Poncz"'
Autor:
Brian D. Adair, Conroy O. Field, José L. Alonso, Jian-Ping Xiong, Shi-Xian Deng, Hyun Sook Ahn, Eivgeni Mashin, Clary B. Clish, Johannes van Agthoven, Mark Yeager, Youzhong Guo, David A. Tess, Donald W. Landry, Mortimer Poncz, M. Amin Arnaout
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Venous thrombosis (VT) is a common vascular disease associated with reduced survival and a high recurrence rate. VT is initiated by the accumulation of platelets and neutrophils at sites of endothelial cell activation. A role for platelet α
Externí odkaz:
https://doaj.org/article/5cb4e38292ca4761ba710d35e201c213
Platelet factor 4 (CXCL4/PF4) upregulates matrix metalloproteinase-2 (MMP-2) in gingival fibroblasts
Autor:
Hoa T. Le, Kalyan Golla, Ryan Karimi, Michael R. Hughes, Flavia Lakschevitz, Douglas B. Cines, M. Anna Kowalska, Mortimer Poncz, Kelly M. McNagny, Lari Häkkinen, Hugh Kim
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Periodontitis is a chronic inflammatory disease characterized by the release of matrix metalloproteinases (MMPs) from resident connective tissue cells in tooth-supporting tissues (periodontium). Platelet activation, and the attendant release
Externí odkaz:
https://doaj.org/article/c2467ba58de749a98460d3e7a5fb6c55
Autor:
Katie D. Mauro, Michele P. Lambert, M. Anna Kowalska, Vincent J. Thawley, Mortimer Poncz, Cynthia M. Otto
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
ObjectiveSeptic peritonitis is associated with significant morbidity and mortality. As a potential therapeutic agent in the treatment of sepsis, 2-O, 3-O desulfated heparin (ODSH) reduces histones and platelet factor 4 (PF4) in mouse sepsis models. T
Externí odkaz:
https://doaj.org/article/f01c027bfb714645a4eebc6646d84295
Autor:
Sokratis A. Apostolidis, Amrita Sarkar, Heather M. Giannini, Rishi R. Goel, Divij Mathew, Aae Suzuki, Amy E. Baxter, Allison R. Greenplate, Cécile Alanio, Mohamed Abdel-Hakeem, Derek A. Oldridge, Josephine R. Giles, Jennifer E. Wu, Zeyu Chen, Yinghui Jane Huang, Jonathan Belman, Ajinkya Pattekar, Sasikanth Manne, Oliva Kuthuru, Jeanette Dougherty, Brittany Weiderhold, Ariel R. Weisman, Caroline A. G. Ittner, Sigrid Gouma, Debora Dunbar, Ian Frank, Alexander C. Huang, Laura A. Vella, The UPenn COVID Processing Unit, John P. Reilly, Scott E. Hensley, Lubica Rauova, Liang Zhao, Nuala J. Meyer, Mortimer Poncz, Charles S. Abrams, E. John Wherry, Sharon Adamski, Zahidul Alam, Mary M. Addison, Katelyn T. Byrne, Aditi Chandra, Hélène C. Descamps, Nicholas Han, Yaroslav Kaminskiy, Shane C. Kammerman, Justin Kim, Jacob T. Hamilton, Nune Markosyan, Julia Han Noll, Dalia K. Omran, Eric Perkey, Elizabeth M. Prager, Dana Pueschl, Austin Rennels, Jennifer B. Shah, Jake S. Shilan, Nils Wilhausen, Ashley N. Vanderbeck
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Patients with COVID-19 present with a wide variety of clinical manifestations. Thromboembolic events constitute a significant cause of morbidity and mortality in patients infected with SARS-CoV-2. Severe COVID-19 has been associated with hyperinflamm
Externí odkaz:
https://doaj.org/article/f380b6f884834140a346b9249d88cbb6
Autor:
Brian D. Adair, José L. Alonso, Johannes van Agthoven, Vincent Hayes, Hyun Sook Ahn, I-Shing Yu, Shu-Wha Lin, Jian-Ping Xiong, Mortimer Poncz, M. Amin Arnaout
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Current inhibitors of platelet integrin αIIbβ3 cause excessive bleeding, which limited their clinical use in cardiac patients. Here the authors design pure orthosteric αIIbβ3 inhibitors that prevent platelet aggregation and thrombosis without cau
Externí odkaz:
https://doaj.org/article/42565adb3ba2424890108c840e099336
Autor:
Cindy Lin, Laura Garcia-Gerique, Erin E. Bonner, Jerome Mastio, Matthew Rosenwasser, Zachary Cruz, Michael Lawler, Luca Bernabei, Kar Muthumani, Qin Liu, Mortimer Poncz, Thomas Vogl, Marie Törngren, Helena Eriksson, Dan T. Vogl, Dmitry I. Gabrilovich, Yulia Nefedova
Publikováno v:
Cancer Research Communications. 3:420-430
Multiple myeloma is characterized by clonal proliferation of plasma cells that accumulate preferentially in the bone marrow (BM). The tumor microenvironment is one of the leading factors that promote tumor progression. Neutrophils and monocytes are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40a8cad0bd0e3990cbdb3fa03e5900d2
https://doi.org/10.1158/2767-9764.crc-22-0368
https://doi.org/10.1158/2767-9764.crc-22-0368
Autor:
Zheng Cai, Khalil Bdeir, Serge V. Yarovoi, Lubica Rauova, Gowthami M. Arepally, Sanjay Khandelwal, Jerome Rollin, Yves Gruel, Sergei Zaitsev, Mortimer Poncz, Mark I. Greene, Douglas B. Cines
Publikováno v:
Journal of Thrombosis and Haemostasis. 21:652-666
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97196fa1556c55e8d6f2bd87aa40e34a
https://doi.org/10.1016/j.jtha.2022.11.043
https://doi.org/10.1016/j.jtha.2022.11.043
Autor:
Jialing Bao, Biying Mo, Guozhen An, Jian Luo, Mortimer Poncz, Guoqing Pan, Tian Li, Zeyang Zhou
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Microsporidia are a group of spore-forming, fungus-related pathogens that can infect both invertebrates and vertebrates including humans. The primary infection site is usually digestive tract, but systemic infections occur as well and cause damages t
Externí odkaz:
https://doaj.org/article/b0b7367277104edab4dde64e22fb9d08
Publikováno v:
Blood. 141:260-270
Heterozygous defects in runt-related transcription factor 1 (RUNX1) are causative of a familial platelet disorder with associated myeloid malignancy (FPDMM). Because RUNX1-deficient animal models do not mimic bleeding disorder or leukemic risk associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69c52def3466d778158eaef1b8878b9
https://doi.org/10.1182/blood.2022017561
https://doi.org/10.1182/blood.2022017561
Autor:
Elizabeth Tkaczynski, Abinaya Arulselvan, John Tkaczynski, Stephen Avery, Liqing Xiao, Beverly Torok-Storb, Kraig Abrams, Narayanam V. Rao, Gregory Johnson, Thomas P. Kennedy, Mortimer Poncz, Michele P. Lambert
Publikováno v:
Blood Advances, Vol 2, Iss 7, Pp 754-761 (2018)
Abstract: Thrombocytopenia is a significant complication of chemotherapy and radiation therapy. Platelet factor 4 (PF4; CXCL4) is a negative paracrine of megakaryopoiesis. We have shown that PF4 levels are inversely related to steady-state platelet c
Externí odkaz:
https://doaj.org/article/4b85415beb2e418f91dface3b15ff817