Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Morten T Venø"'
Autor:
Renata Vieira de Sá, Emma Sudria-Lopez, Marta Cañizares Luna, Oliver Harschnitz, Dianne M. A. van den Heuvel, Sandra Kling, Danielle Vonk, Henk-Jan Westeneng, Henk Karst, Lauri Bloemenkamp, Suzy Varderidou-Minasian, Domino K. Schlegel, Mayte Mars, Mark H. Broekhoven, Nicky C. H. van Kronenburg, Youri Adolfs, Vamshidhar R. Vangoor, Rianne de Jongh, Tijana Ljubikj, Lianne Peeters, Sabine Seeler, Enric Mocholi, Onur Basak, David Gordon, Fabrizio Giuliani, Tessa Verhoeff, Giel Korsten, Teresa Calafat Pla, Morten T. Venø, Jørgen Kjems, Kevin Talbot, Michael A. van Es, Jan H. Veldink, Leonard H. van den Berg, Pavol Zelina, R. Jeroen Pasterkamp
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Intermediate-length repeat expansions in ATAXIN-2 (ATXN2) are the strongest genetic risk factor for amyotrophic lateral sclerosis (ALS). At the molecular level, ATXN2 intermediate expansions enhance TDP-43 toxicity and pathology. However, wh
Externí odkaz:
https://doaj.org/article/f542924285bc411ab2ef82b8bba3d188
Autor:
Mateja Rybiczka-Tešulov, Oxana Garritsen, Morten T. Venø, Laura Wieg, Roland van Dijk, Karim Rahimi, Andreia Gomes-Duarte, Marina de Wit, Lieke L. van de Haar, Lars Michels, Nicky C. H. van Kronenburg, Christiaan van der Meer, Jørgen Kjems, Vamshidhar R. Vangoor, R. Jeroen Pasterkamp
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Midbrain dopamine (mDA) neurons play an essential role in cognitive and motor behaviours and are linked to different brain disorders. However, the molecular mechanisms underlying their development, and in particular the role of non-coding RN
Externí odkaz:
https://doaj.org/article/8aec0e9cc09c4f6da40dc00803982a61
Autor:
Daniel S.K. Liu, Jisce R. Puik, Bhavik Y. Patel, Morten T. Venø, Mahrou Vahabi, Mireia Mato Prado, Jason P. Webber, Eleanor Rees, Flora M. Upton, Kate Bennett, Catherine Blaker, Benoit Immordino, Annalisa Comandatore, Luca Morelli, Shivan Sivakumar, Rutger-Jan Swijnenburg, Marc G. Besselink, Long R. Jiao, Geert Kazemier, Elisa Giovannetti, Jonathan Krell, Adam E. Frampton
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-17 (2024)
Abstract Background Distinguishing benign from malignant pancreaticobiliary disease is challenging because of the absence of reliable biomarkers. Circulating extracellular vesicles (EVs) have emerged as functional mediators between cells. Their cargo
Externí odkaz:
https://doaj.org/article/2f67910999e14d67b5bad68ba843ae62
Autor:
Niraj Khemka, Gareth Morris, Laleh Kazemzadeh, Lara S. Costard, Valentin Neubert, Sebastian Bauer, Felix Rosenow, Morten T. Venø, Jørgen Kjems, David C. Henshall, Jochen H. M. Prehn, Niamh M. C. Connolly
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Epileptogenesis is the process by which a normal brain becomes hyperexcitable and capable of generating spontaneous recurrent seizures. The extensive dysregulation of gene expression associated with epileptogenesis is shaped, in part, by mic
Externí odkaz:
https://doaj.org/article/aec36402be9d4848857dd99eb744d751
Autor:
Katrine Svenningsen, Morten T Venø, Kim Henningsen, Anne S Mallien, Line Jensen, Trine Christensen, Jørgen Kjems, Barbara Vollmayr, Ove Wiborg
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160318 (2016)
Depression is a highly heterogeneous disorder presumably caused by a combination of several factors ultimately causing the pathological condition. The genetic liability model of depression is likely to be of polygenic heterogeneity. miRNAs can regula
Externí odkaz:
https://doaj.org/article/abffb60e380a42fb9d06be5452013edf
Autor:
Flavia Scoyni, Valeriia Sitnikova, Luca Giudice, Paula Korhonen, Davide M. Trevisan, Ana Hernandez de Sande, Mireia Gomez-Budia, Raisa Giniatullina, Irene F. Ugidos, Hiramani Dhungana, Cristiana Pistono, Nea Korvenlaita, Nelli-Noora Välimäki, Salla M. Kangas, Anniina E. Hiltunen, Emma Gribchenko, Minna U. Kaikkonen-Määttä, Jari Koistinaho, Seppo Ylä-Herttuala, Reetta Hinttala, Morten T. Venø, Junyi Su, Markus Stoffel, Anne Schaefer, Nikolaus Rajewsky, Jørgen Kjems, Mary P. LaPierre, Monika Piwecka, Jukka Jolkkonen, Rashid Giniatullin, Thomas B. Hansen, Tarja Malm
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113862- (2024)
Summary: Brain functionality relies on finely tuned regulation of gene expression by networks of non-coding RNAs (ncRNAs) such as the one composed by the circular RNA ciRS-7 (also known as CDR1as), the microRNA miR-7, and the long ncRNA Cyrano. We de
Externí odkaz:
https://doaj.org/article/3f5181ebf602423b89fa5aca16a2796d
Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy
Autor:
Elizabeth Brindley, Mona Heiland, Catherine Mooney, Mairead Diviney, Omar Mamad, Thomas D. M. Hill, Yan Yan, Morten T. Venø, Cristina R. Reschke, Aasia Batool, Elena Langa, Amaya Sanz-Rodriguez, Janosch P. Heller, Gareth Morris, Karen Conboy, Jørgen Kjems, Gary P. Brennan, David C. Henshall
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
The diagnosis of epilepsy is complex and challenging and would benefit from the availability of molecular biomarkers, ideally measurable in a biofluid such as blood. Experimental and human epilepsy are associated with altered brain and blood levels o
Externí odkaz:
https://doaj.org/article/5a12b88c05be4334969707b5a82ff1e7
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Short-read sequencing methods cannot delineate internal exon composition and alternative splicing events of long and multi-exon circular RNAs (circRNAs). Here the authors provide a global map of full-length circRNAs by long-read sequencing in human a
Externí odkaz:
https://doaj.org/article/caf8add5fb2e4f0f8efcdf021c9ce999
Autor:
Andreia Gomes-Duarte, Morten T. Venø, Marina de Wit, Ketharini Senthilkumar, Mark H. Broekhoven, Joëlle van den Herik, Fleur R. Heeres, Daniëlle van Rossum, Mateja Rybiczka-Tesulov, Ivano Legnini, Peter C. van Rijen, Pieter van Eijsden, Peter H. Gosselaar, Nikolaus Rajewsky, Jørgen Kjems, Vamshidhar R. Vangoor, R. Jeroen Pasterkamp
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Mesial temporal lobe epilepsy (mTLE) is a chronic disease characterized by recurrent seizures that originate in the temporal lobes of the brain. Anti-epileptic drugs (AEDs) are the standard treatment for managing seizures in mTLE patients, but are fr
Externí odkaz:
https://doaj.org/article/410e483a1b334ae3bc86f6ea487598f0
Autor:
Andreia Gomes-Duarte, Sebastian Bauer, Morten T. Venø, Braxton A. Norwood, David C. Henshall, Jørgen Kjems, Felix Rosenow, Vamshidhar R. Vangoor, R. Jeroen Pasterkamp
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Mesial temporal lobe epilepsy (mTLE) is a common form of epilepsy and is characterized by recurrent spontaneous seizures originating from the temporal lobe. The majority of mTLE patients develop pharmacoresistance to available anti-epileptic drugs (A
Externí odkaz:
https://doaj.org/article/70b03fa720234c7ebc502338c5759a82