Phosphorylation-Elicited Quaternary Changes of GA Binding Protein in Transcriptional Activation

Autor: Morten Sunesen, Jean-Pierre Changeux, Morten O. Christensen, Monique Huchet-Dymanus

Publikováno v: Molecular and Cellular Biology. 23:8008-8018

Enrichment of nicotinic acetylcholine receptors (nAChR) on the tip of the subjunctional folds of the postsynaptic membrane is a central event in the development of the vertebrate neuromuscular junction. This is attained, in part, through a selective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8a9671c3399bfa32bdb5092cf18194
https://doi.org/10.1128/mcb.23.22.8008-8018.2003

Ligand Gated Ion Channels on the Qube

Autor: Hervør L. Olsen, Anders Lindqvist, Søren Friis, Rasmus B. Jacobsen, Morten Sunesen, Lars Damgaard Løjkner

Publikováno v: Biophysical Journal. 104(2)

Drug discovery on ion channel targets has been an under-explored territory because suitable screening tools for patch clamp were missing. This changed during the 2000's with the introduction of automated patch clamp (APC) devices. Still, the throughp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531a6ad3f04dad18344394d71f486899

Study of TRP channels by automated patch clamp systems

Autor: Morten, Sunesen, Rasmus B, Jacobsen

Publikováno v: Advances in experimental medicine and biology. 704

Ion channels are responsible for the permeation of ions across the membrane and their central role in cellular physiology is well established. Historically, the direct study of ion channels has been considered technically challenging. As such, a sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0efd7aa17a640a3bc2614b64d5185c67
https://pubmed.ncbi.nlm.nih.gov/21290291

Classification of drugs based on properties of sodium channel inhibition: a comparative automated patch-clamp study

Autor: Robert Karoly, Nora Lenkey, E. Sylvester Vizi, László Fodor, Peter Lukacs, Arpad Mike, Morten Sunesen

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e15568 (2010)
PLoS ONE

Background There is only one established drug binding site on sodium channels. However, drug binding of sodium channels shows extreme promiscuity: ∼25% of investigated drugs have been found to potently inhibit sodium channels. The structural divers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a6650b661fc7ed81300e2b4145f5e7
http://europepmc.org/articles/PMC3004914?pdf=render

Mechanism of Cl- selection by a glutamate-gated chloride (GluCl) receptor revealed through mutations in the selectivity filter

Autor: Nathalie Savatier-Duclert, Yoav Paas, Asher Peretz, Lia Prado de Carvalho, Bernard Attali, Virginie Dufresne, Morten Sunesen, Gilad Gibor, Jean-Pierre Changeux, Régis Grailhe

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2006, 281 (21), pp.14875-81. ⟨10.1074/jbc.M511657200⟩
Journal of Biological Chemistry, 2006, 281 (21), pp.14875-81. ⟨10.1074/jbc.M511657200⟩

International audience; To learn about the mechanism of ion charge selectivity by invertebrate glutamate-gated chloride (GluCl) channels, we swapped segments between the GluClbeta receptor of Caenorhabditis elegans and the vertebrate cationic alpha7-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bbd77ab10c61042c9441facda328fb6
https://hal-pasteur.archives-ouvertes.fr/pasteur-00161476