Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor.

Autor: Ekaterina N Lyukmanova, Mikhail A Shulepko, Denis Kudryavtsev, Maxim L Bychkov, Dmitrii S Kulbatskii, Igor E Kasheverov, Maria V Astapova, Alexey V Feofanov, Morten S Thomsen, Jens D Mikkelsen, Zakhar O Shenkarev, Victor I Tsetlin, Dmitry A Dolgikh, Mikhail P Kirpichnikov

Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0149733 (2016)

SLURP-1 is a secreted toxin-like Ly-6/uPAR protein found in epithelium, sensory neurons and immune cells. Point mutations in the slurp-1 gene cause the autosomal inflammation skin disease Mal de Meleda. SLURP-1 is considered an autocrine/paracrine ho

Externí odkaz: https://doaj.org/article/83af7a1944694beaa6e9ee97a1f0dfd1

Acute phencyclidine administration induces c-Fos-immunoreactivity in interneurons in cortical and subcortical regions

Autor: Imre Kalló, Morten S. Thomsen, Jens D. Mikkelsen, Mona E. Hervig

Publikováno v: Neuroscience. 334:13-25

Dysfunction of N-Methyl-d-aspartate receptors (NMDARs) is believed to underlie some of the symptoms in schizophrenia, and non-competitive NMDAR antagonists (including phencyclidine (PCP)) are widely used as pharmacological schizophrenia models. Furth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25111c203c4dbf80e19a5f67b592a97
https://doi.org/10.1016/j.neuroscience.2016.07.028

Reduced basal and novelty-induced levels of activity-regulated cytoskeleton associated protein (Arc) and c-Fos mRNA in the cerebral cortex and hippocampus of APPswe/PS1ΔE9 transgenic mice

Autor: Morten S. Thomsen, Ditte Z. Christensen, Jens D. Mikkelsen

Publikováno v: Neurochemistry International. 63:54-60

Activity-regulated cytoskeletal-associated protein (Arc) and c-Fos are immediate early gene (IEG) products induced by novelty in the hippocampus and involved in the consolidation of synaptic plasticity and long-term memory. We investigated whether in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b210ae18f7db2fd62f1c1b8856e501
https://doi.org/10.1016/j.neuint.2013.04.002

Functional interaction between Lypd6 and nicotinic acetylcholine receptors

Autor: Maria Arvaniti, Hong Wang, Neeraj Soni, Morten S. Thomsen, Anders B. Klein, Jacob Wienecke, Pretal P. Muldoon, Marjorie C. Gondré-Lewis, Nathalie Thiriet, Jens D. Mikkelsen, M. Imad Damaj, Kristi A. Kohlmeier, Lars H. Pinborg, Majbrit M. Jensen

Publikováno v: Arvaniti, M, Jensen, M M, Soni, N, Wang, H, Klein, A B, Thiriet, N, Pinborg, L H, Muldoon, P P, Wienecke, J, Imad Damaj, M, Kohlmeier, K A, Gondré-Lewis, M C, Mikkelsen, J D & Thomsen, M S 2016, ' Functional interaction between Lypd6 and nicotinic acetylcholine receptors ', Journal of Neurochemistry, vol. 138, no. 6, pp. 806-820 . https://doi.org/10.1111/jnc.13718
Journal of Neurochemistry

Nicotinic acetylcholine receptors (nAChRs) affect multiple physiological functions in the brain and their functions are modulated by regulatory proteins of the Lynx family. Here, we report for the first time a direct interaction of the Lynx protein L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b3e5c78397c1576988896905c395b7
https://curis.ku.dk/portal/da/publications/functional-interaction-between-lypd6-and-nicotinic-acetylcholine-receptors(900df837-0c01-4419-bdeb-80a3e42d8813).html

Secreted Isoform of Human Lynx1 (SLURP-2): Spatial Structure and Pharmacology of Interactions with Different Types of Acetylcholine Receptors

Autor: Mikhail A. Shulepko, Roman G. Efremov, D.S. Kulbatskii, Anton O. Chugunov, A. S. Arseniev, Ekaterina N. Lyukmanova, Maria Arvaniti, T. Schaer, Eva Dolejší, Zakhar O. Shenkarev, Vladimir Dolezal, Morten S. Thomsen, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Daniel Bertrand, M L Bychkov, Alexander S. Paramonov

Publikováno v: Scientific Reports

Human-secreted Ly-6/uPAR-related protein-2 (SLURP-2) regulates the growth and differentiation of epithelial cells. Previously, the auto/paracrine activity of SLURP-2 was considered to be mediated via its interaction with the α3β2 subtype of the nic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02fdcee904545e0c50a0dbc8fb0c1990
https://pubmed.ncbi.nlm.nih.gov/27485575