Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Morten Orebo Holmström"'
Autor:
Vibe Skov, Lasse Kjær, Hans Hasselbalch, Mads Andersen, Morten Orebo Holmström, Maria Perez Penco, Thomas Lisle, Josephine Hallundbæk Ruders, Jacob Handlos Grauslund
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/1fc7a6af3a214a96a3bcd8b2bf7dd201
Autor:
Morten Orebo Holmström, Morten Andersen, Sofie Traynor, Shamaila Munir Ahmad, Thomas Landkildehus Lisle, Jacob Handlos Grauslund, Vibe Skov, Lasse Kjær, Johnny T. Ottesen, Morten Frier Gjerstorff, Hans Carl Hasselbalch, Mads Hald Andersen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundTherapeutic cancer vaccination against mutant calreticulin (CALR) in patients with CALR-mutant (CALRmut) myeloproliferative neoplasms (MPN) induces strong T-cell responses against mutant CALR yet fails to demonstrate clinical activity. Infi
Externí odkaz:
https://doaj.org/article/ea1a4e7fa4a849529a58c4ed8bd4131d
Autor:
Olivia Lie-Andersen, Mie Linder Hübbe, Krishanthi Subramaniam, Daniel Steen-Jensen, Ann Christina Bergmann, Daniel Justesen, Morten Orebo Holmström, Lance Turtle, Sune Justesen, Telma Lança, Morten Hansen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Induction of a lasting protective immune response is dependent on presentation of epitopes to patrolling T cells through the HLA complex. While peptide:HLA (pHLA) complex affinity alone is widely exploited for epitope selection, we demonstrate that i
Externí odkaz:
https://doaj.org/article/93081d72d7b44f6aafc8a1eb021bf08a
Autor:
Mads Hald Andersen, Özcan Met, Inge Marie Svane, Morten Orebo Holmström, Thomas Landkildehus Lisle, Rasmus Erik Johansson Mortensen, Jane P Hasselby, Gro L Willemoe, Julia Johansen, Dorte L Nielsen, Inna M Chen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 3 (2023)
Background Circulating transforming growth factor-β (TGF-β)-specific T cells that recognize TGF-β-expressing immune regulatory cells have been described in patients with cancer. TGF-β-derived peptide vaccination modulates the tumor microenvironme
Externí odkaz:
https://doaj.org/article/86495d8680aa4a59a67aa19a352593ff
Autor:
Sofie Kirial Mørk, Per Kongsted, Marie Christine Wulff Westergaard, Benedetta Albieri, Joachim Stoltenborg Granhøj, Marco Donia, Evelina Martinenaite, Morten Orebo Holmström, Kasper Madsen, Anders H. Kverneland, Julie Westerlin Kjeldsen, Rikke Boedker Holmstroem, Cathrine Lund Lorentzen, Nis Nørgaard, Lars Vibe Andreasen, Grith Krøyer Wood, Dennis Christensen, Michael Schantz Klausen, Sine Reker Hadrup, Per thor Straten, Mads Hald Andersen, Inge Marie Svane
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundThe B-cell lymphoma-extra-large (Bcl-XL) protein plays an important role in cancer cells’ resistance to apoptosis. Pre-clinical studies have shown that vaccination with Bcl-XL-derived peptides can induce tumor-specific T cell responses th
Externí odkaz:
https://doaj.org/article/9c685780fcea4f8588fac16748a76464
Autor:
Jacob Handlos Grauslund, Morten Orebo Holmström, Evelina Martinenaite, Thomas Landkildehus Lisle, Hannah Jorinde Glöckner, Daniel El Fassi, Uffe Klausen, Rasmus E. J. Mortensen, Nicolai Jørgensen, Lasse Kjær, Vibe Skov, Inge Marie Svane, Hans Carl Hasselbalch, Mads Hald Andersen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionArginase-1 (ARG1) and Programed death ligand-1 (PD-L1) play a vital role in immunosuppression in myeloproliferative neoplasms (MPNs) and directly inhibit T-cell activation and proliferation. We previously identified spontaneous T-cell res
Externí odkaz:
https://doaj.org/article/5bb1896ca9234691adc0750d751600e6
Autor:
Marco Donia, Mads Hald Andersen, Lars Grøntved, Daniel Hargbøl Madsen, Inés Lecoq, Evelina Martinenaite, Mia Aaboe Jørgensen, Stine Emilie Weis-Banke, Morten Orebo Holmström, Maria Perez-Penco, Aimilia Schina, Mie Linder Hübbe, Majken Siersbæk, Niels Ødum, Lucia Lara de la Torre, Simone Kloch Bendtsen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 12 (2022)
Background Pancreatic ductal adenocarcinoma (PDAC) is associated with very poor survival, making it the third and fourth leading cause of all cancer-related deaths in the USA and European Union, respectively. The tumor microenvironment (TME) in PDAC
Externí odkaz:
https://doaj.org/article/9b7ffc36e9674c6099fd906a29e40d4b
Autor:
Simone Kloch Bendtsen, Maria Perez-Penco, Mie Linder Hübbe, Evelina Martinenaite, Morten Orebo Holmström, Stine Emilie Weis-Banke, Nicolai Grønne Dahlager Jørgensen, Mia Aaboe Jørgensen, Shamaila Munir Ahmad, Kasper Mølgaard Jensen, Christina Friese, Mia Thorup Lundsager, Astrid Zedlitz Johansen, Marco Carretta, Niels Ødum, Özcan Met, Inge Marie Svane, Daniel Hargbøl Madsen, Mads Hald Andersen
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Galectin-3 (Gal3) can be expressed by many cells in the tumor microenvironment (TME), including cancer cells, cancer-associated fibroblasts, tumor-associated macrophages, and regulatory T cells (Tregs). In addition to immunosuppression, Gal3 expressi
Externí odkaz:
https://doaj.org/article/4a88182fd3824e069baeb2dcda39bf1d
Autor:
Uffe Klausen, Jacob Handlos Grauslund, Nicolai Grønne Dahlager Jørgensen, Shamaila Munir Ahmad, Merete Jonassen, Stine Emilie Weis-Banke, Evelina Martinenaite, Lone Bredo Pedersen, Thomas Landkildehus Lisle, Anne Ortved Gang, Lisbeth Enggaard, Morten Hansen, Morten Orebo Holmström, Özcan Met, Inge Marie Svane, Carsten Utoft Niemann, Lars Møller Pedersen, Mads Hald Andersen
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Chronic lymphocytic leukemia (CLL) patients with unmutated immunoglobulin heavy chain (IgHV) are at risk of early disease progression compared to patients with mutated IgHV. As a preventive strategy, we treated 19 previously untreated CLL patients wi
Externí odkaz:
https://doaj.org/article/84bc1f77bf5c4507a17a70aaa4b29f52
Autor:
Marco Donia, Mads Hald Andersen, Özcan Met, Lars Grøntved, Daniel Hargbøl Madsen, Inge Marie Svane, Mia Aaboe Jørgensen, Stine Emilie Weis-Banke, Morten Orebo Holmström, Thomas Landkildehus Lisle, Maria Perez-Penco, Aimilia Schina, Mie Linder Hübbe, Majken Siersbæk, Niels Ødum
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 10 (2022)
Background High expression of the metabolic enzyme arginase-2 (ARG2) by cancer cells, regulatory immune cells, or cells of the tumor stroma can reduce the availability of arginine (L-Arg) in the tumor microenvironment (TME). Depletion of L-Arg has de
Externí odkaz:
https://doaj.org/article/fff8e87a81a74470aaa2d8cac2b4d443