Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Morten Muhlig, Nielsen"'
Autor:
Maria Danielsen, Thomas Emmanuel, Morten Muhlig Nielsen, Lise Maria Lindahl, Maria Gluud, Niels Ødum, Line Raaby, Torben Steiniche, Lars Iversen, Rikke Bech, Terkild Brink Buus, Claus Johansen
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionThe majority of patients with mycosis fungoides (MF) have an indolent disease course, but a substantial fraction (20-30%) of patients progress to advanced stages – usually with a grave prognosis. Early differentiation between indolent a
Externí odkaz:
https://doaj.org/article/032ca7a08f2441cebfb7829eb806389e
Autor:
Trine Line Hauge Okholm, Andreas Bjerregaard Kamstrup, Morten Muhlig Nielsen, Anne Kruse Hollensen, Mette Laugesen Graversgaard, Matilde Helbo Sørensen, Lasse Sommer Kristensen, Søren Vang, Samuel S Park, Eugene Yeo, Lars Dyrskjøt, Jørgen Kjems, Jakob Skou Pedersen, Christian Kroun Damgaard
Publikováno v:
eLife, Vol 13 (2024)
Circular RNAs represent a class of endogenous RNAs that regulate gene expression and influence cell biological decisions with implications for the pathogenesis of several diseases. Here, we disclose a novel gene-regulatory role of circHIPK3 by combin
Externí odkaz:
https://doaj.org/article/2da5c04d5367422eae198b4052d44353
Autor:
Gustav Alexander Poulsgaard, Simon Grund Sørensen, Randi Istrup Juul, Morten Muhlig Nielsen, Jakob Skou Pedersen
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-19 (2023)
Abstract Background Cancer mutations accumulate through replication errors and DNA damage coupled with incomplete repair. Individual mutational processes often show nucleotide sequence and functional region preferences. As a result, some sequence con
Externí odkaz:
https://doaj.org/article/6c3345d840ee4c4eafa9b0c2c59bc60b
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-15 (2021)
Abstract Large sets of whole cancer genomes make it possible to study mutation hotspots genome-wide. Here we detect, categorize, and characterize site-specific hotspots using 2279 whole cancer genomes from the Pan-Cancer Analysis of Whole Genomes pro
Externí odkaz:
https://doaj.org/article/d01e75884cdc498f9e404ea996710e9f
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract High throughput single-cell RNA sequencing (scRNAseq) can provide mRNA expression profiles for thousands of cells. However, miRNAs cannot currently be studied at the same scale. By exploiting that miRNAs bind well-defined sequence motifs and
Externí odkaz:
https://doaj.org/article/72cae6fbba4641afbfee8eb283e5e781
Autor:
Trine Line Hauge Okholm, Shashank Sathe, Samuel S. Park, Andreas Bjerregaard Kamstrup, Asta Mannstaedt Rasmussen, Archana Shankar, Zong Ming Chua, Niels Fristrup, Morten Muhlig Nielsen, Søren Vang, Lars Dyrskjøt, Stefan Aigner, Christian Kroun Damgaard, Gene W. Yeo, Jakob Skou Pedersen
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-22 (2020)
Abstract Background Circular RNAs (circRNAs) are stable, often highly expressed RNA transcripts with potential to modulate other regulatory RNAs. A few circRNAs have been shown to bind RNA-binding proteins (RBPs); however, little is known about the p
Externí odkaz:
https://doaj.org/article/07a2b5a8c7034ce9ae1a8efb8d815836
Publikováno v:
Algorithms for Molecular Biology, Vol 13, Iss 1, Pp 1-11 (2018)
Abstract Background Motif analysis methods have long been central for studying biological function of nucleotide sequences. Functional genomics experiments extend their potential. They typically generate sequence lists ranked by an experimentally acq
Externí odkaz:
https://doaj.org/article/61a03bdbb36e4f6dbd5ccac65365961b
Autor:
Johanna Bertl, Qianyun Guo, Malene Juul, Søren Besenbacher, Morten Muhlig Nielsen, Henrik Hornshøj, Jakob Skou Pedersen, Asger Hobolth
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-15 (2018)
Abstract Background Detailed modelling of the neutral mutational process in cancer cells is crucial for identifying driver mutations and understanding the mutational mechanisms that act during cancer development. The neutral mutational process is ver
Externí odkaz:
https://doaj.org/article/1b55cf0177f64be48276f4a107619169
Autor:
Anna Katharina Seitz, Lise Lotte Christensen, Emil Christensen, Kasper Faarkrog, Marie Stampe Ostenfeld, Jakob Hedegaard, Iver Nordentoft, Morten Muhlig Nielsen, Johan Palmfeldt, Michelle Thomson, Michael Theis Solgaard Jensen, Roman Nawroth, Tobias Maurer, Torben Falck Ørntoft, Jørgen Bjerggaard Jensen, Christian Kroun Damgaard, Lars Dyrskjøt
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Aberrant expression of long non-coding RNAs (lncRNAs) has been regarded as a critical component in bladder cancer (BC) and lncRNAs have been associated with BC development and progression although their overall expression and functional sign
Externí odkaz:
https://doaj.org/article/d1bf7670985049f9b07d1d977c912484
Autor:
Nkerorema Djodji Damas, Michela Marcatti, Christophe Côme, Lise Lotte Christensen, Morten Muhlig Nielsen, Roland Baumgartner, Helene Maria Gylling, Giulia Maglieri, Carsten Friis Rundsten, Stefan E. Seemann, Nicolas Rapin, Simon Thézenas, Søren Vang, Torben Ørntoft, Claus Lindbjerg Andersen, Jakob Skou Pedersen, Anders H. Lund
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Several lncRNAs have been linked to cancer. Here, the authors identify SNHG5 as a long non-coding RNA promoting proliferation and survival of colorectal cancer cells by protecting specific mRNAs from STAU1-mediated degradation.
Externí odkaz:
https://doaj.org/article/b798c3c5b5f543a9b6ab76d138075453