Zobrazeno 1 - 10
of 396
pro vyhledávání: '"Morten Meldal"'
Autor:
Hongxia Hu, Christian Kofoed, Ming Li, Juliana Pereira Lopes Gonçalves, Jonas Hansen, Martin Wolfram, Axel Kornerup Hansen, Camilla Hartmann Friis Hansen, Frederik Diness, Sanne Schoffelen, Morten Meldal
Publikováno v:
ACS Central Science, Vol 5, Iss 2, Pp 259-269 (2019)
Externí odkaz:
https://doaj.org/article/df07871a47634d12b594183b96701d81
Autor:
Morten Meldal, Sanne Schoffelen
Publikováno v:
F1000Research, Vol 5 (2016)
The properties of biosensors, biomedical implants, and other materials based on immobilized proteins greatly depend on the method employed to couple the protein molecules to their solid support. Covalent, site-specific immobilization strategies are r
Externí odkaz:
https://doaj.org/article/344aed61ac014a7a90fa9908a1a97b1a
Publikováno v:
Wolfram, M, Tiwari, M K, Hassenkam, T, Li, M, Bjerrum, M J & Meldal, M 2023, ' Cascade autohydrolysis of Alzheimer's Aβ peptides ', Chemical Science, vol. 14, no. 19, pp. 4986–4996 . https://doi.org/10.1039/d2sc06668h
Protein/peptide self-assembly into amyloid structures associates with major neurodegenerative disorders such as Alzheimer's disease (AD). Soluble assemblies (oligomers) of the A beta peptide and their aggregates are perceived as neurotoxic species in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad20e10ee75a9cdc6e13b37c37426606
https://curis.ku.dk/portal/da/publications/cascade-autohydrolysis-of-alzheimers-a-peptides(3107948d-f587-4d6d-944b-e47fdb704cb5).html
https://curis.ku.dk/portal/da/publications/cascade-autohydrolysis-of-alzheimers-a-peptides(3107948d-f587-4d6d-944b-e47fdb704cb5).html
Publikováno v:
Chemical Communications. 57:895-898
Solid-phase synthesis of peptides (SPPS) with release through formation of C-terminal γ-, δ-, or ε-lactams is presented. The natural products ciliatamide A and C were synthesized in up to 90% yield. Peptides carrying C-terminal lactams were shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63fb56ecdd9223105017f6faa031df6c
https://doi.org/10.1039/d0cc06018f
https://doi.org/10.1039/d0cc06018f
Autor:
Daniel H. Madsen, Andrej Thompson, Frederik Diness, Maria Teresa Oliveira, Yuanyuan Wang, Morten Meldal
Publikováno v:
Chemistry – A European Journal. 26:15825-15829
A variant of the A3 coupling reaction was developed utilizing in situ generated N-carbamoyliminium ions. The tandem INCIC/A3 -coupling sequence provided a facile one-pot synthesis of dihydroquinazolinone derivatives. The scope of the reaction was dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::384e3e1baab1974fbefbfcca45d36726
https://doi.org/10.1002/chem.202003117
https://doi.org/10.1002/chem.202003117
Autor:
Frederik Diness, Morten Meldal
Publikováno v:
Trends in Chemistry. 2:569-584
CuAAC chemistry is used to compose incredible synthetic molecular architectures and acts as a true click chemistry reaction allowing densely functional molecular fragments to be joined in a highly controlled manner. Using supercatalysts based on our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16d508d32a13fc135223bb6327aa2924
https://doi.org/10.1016/j.trechm.2020.03.007
https://doi.org/10.1016/j.trechm.2020.03.007
Autor:
Alice Ruth Lapthorn, Morten Meldal
Publikováno v:
Int J Exp Pathol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baffbecd9c651e68723343c7e32bee11
https://doi.org/10.1111/iep.12409
https://doi.org/10.1111/iep.12409
Autor:
Jacob Valdbjørn Olsen, Morten Meldal, Morten Petersen, Frederik Præstholm Jørgensen, Daniel H. Madsen, Mikael Bols, Jeppe Granhøj
Publikováno v:
Journal of Medicinal Chemistry. 62:5191-5216
A series of 35 analogues of Shld with modifications in the A-residue and the C-residues were prepared and investigated for binding to FKBP and GFP accumulation in transgenic plants. The modifications investigated explored variations that were suppose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95317feca6c76645dbea037e1e98d4df
https://doi.org/10.1021/acs.jmedchem.9b00497
https://doi.org/10.1021/acs.jmedchem.9b00497
Publikováno v:
The Journal of Organic Chemistry. 84:6940-6945
Synthesis of azotides and evaluation of these as ligands for enantioselective Lewis acid catalysis is reported. The ligands were readily prepared from the chiral pool of amino acids and perform well in the cobalt(II)-catalyzed formation of asymmetric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4a6b41006957562b18cccef3e198da4
https://doi.org/10.1021/acs.joc.9b00732
https://doi.org/10.1021/acs.joc.9b00732
An overview of convenient methodology and techniques used in solid phase glycopeptide synthesis by the building block approach is given. The practical details of importance in aliphaticO-linked, aromaticO-linked andN-linked glycopeptide synthesis are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7b94ec7de7ebe23173458b12b2fef73
https://doi.org/10.1201/9781003077329-15
https://doi.org/10.1201/9781003077329-15