Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Morten Lindow"'
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)
Antisense oligonucleotides complementary to RNA targets promise generality and ease of drug design. The first systemically administered antisense drug was recently approved for treatment and others are in clinical development. Chemical modifications
Externí odkaz:
https://doaj.org/article/8ef58c960f1349a3bfa88cde142ac342
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 11, p e238 (2007)
microRNAs (miRNAs) are important post-transcriptional regulators, but the extent of this regulation is uncertain, both with regard to the number of miRNA genes and their targets. Using an algorithm based on intragenomic matching of potential miRNAs a
Externí odkaz:
https://doaj.org/article/b974e44039b84d73b66eeef242b63fd4
Autor:
Thomas Hansen, Line Olsen, Morten Lindow, Klaus D Jakobsen, Henrik Ullum, Erik Jonsson, Ole A Andreassen, Srdjan Djurovic, Ingrid Melle, Ingrid Agartz, Håkan Hall, Sally Timm, August G Wang, Thomas Werge
Publikováno v:
PLoS ONE, Vol 2, Iss 9, p e873 (2007)
BACKGROUND: Protein encoding genes have long been the major targets for research in schizophrenia genetics. However, with the identification of regulatory microRNAs (miRNAs) as important in brain development and function, miRNAs genes have emerged as
Externí odkaz:
https://doaj.org/article/47cf13a7c2ac4e05983bee8e340ac739
Autor:
Anne Krogh Nøhr, Samuel Demharter, Morana Vitezic, Ida Moltke, Raimund Buller, Anders Albrechtsen, Annika Forsingdal, Morten Lindow, Troels Nielsen
Publikováno v:
Neuropsychopharmacology
Nøhr, A K, Lindow, M, Forsingdal, A, Demharter, S, Nielsen, T, Buller, R, Moltke, I, Vitezic, M & Albrechtsen, A 2021, ' A large-scale genome-wide gene expression analysis in peripheral blood identifies very few differentially expressed genes related to antidepressant treatment and response in patients with major depressive disorder ', Neuropsychopharmacology, vol. 46, no. 7, pp. 1324-1332 . https://doi.org/10.1038/s41386-021-01002-9
Nøhr, A K, Lindow, M, Forsingdal, A, Demharter, S, Nielsen, T, Buller, R, Moltke, I, Vitezic, M & Albrechtsen, A 2021, ' A large-scale genome-wide gene expression analysis in peripheral blood identifies very few differentially expressed genes related to antidepressant treatment and response in patients with major depressive disorder ', Neuropsychopharmacology, vol. 46, no. 7, pp. 1324-1332 . https://doi.org/10.1038/s41386-021-01002-9
A better understanding of the biological factors underlying antidepressant treatment in patients with major depressive disorder (MDD) is needed. We perform gene expression analyses and explore sources of variability in peripheral blood related to ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d8195f4ef5544a9909a7d7cdecce52
http://europepmc.org/articles/PMC8134553
http://europepmc.org/articles/PMC8134553
Autor:
Signe Tang Karlsen, Troels Koch, Jonas Vikeså, Morten Lindow, Pia Særmark, Lykke Pedersen, Peter Hagedorn
Publikováno v:
Molecular Therapy. Nucleic Acids
Well-validated strategies for discovering potent and efficacious antisense oligonucleotides are central to realize the full therapeutic potential of RNA therapy. In this study, we focus on RNA targets where the same sequence of 16-20 nt is found in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ddc35198d8c4e5e79702f14d81a21c7
https://doi.org/10.1016/j.omtn.2019.10.040
https://doi.org/10.1016/j.omtn.2019.10.040
Autor:
Marco Berrera, Marianne Lerbech Jensen, Martin Ebeling, Peter Hagedorn, Marianne R. Møller, Morten Lindow, Troels Koch, Henrik Frydenlund Hansen, Malene Pontoppidan, Heidi Rye Hudlebusch, Andreas Dieckmann, Tina S Bisgaard
Publikováno v:
Nucleic Acids Research
Hagedorn, P H, Pontoppidan, M, Bisgaard, T S, Berrera, M, Dieckmann, A, Ebeling, M, Møller, M R, Hudlebusch, H, Jensen, M L, Hansen, H F, Koch, T & Lindow, M 2018, ' Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice ', Nucleic Acids Research, vol. 46, no. 11, pp. 5366-5380 . https://doi.org/10.1093/nar/gky397
Hagedorn, P H, Pontoppidan, M, Bisgaard, T S, Berrera, M, Dieckmann, A, Ebeling, M, Møller, M R, Hudlebusch, H, Jensen, M L, Hansen, H F, Koch, T & Lindow, M 2018, ' Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice ', Nucleic Acids Research, vol. 46, no. 11, pp. 5366-5380 . https://doi.org/10.1093/nar/gky397
Antisense oligonucleotides that are dependent on RNase H for cleavage and subsequent degradation of complementary RNA are being developed as therapeutics. Besides the intended RNA target, such oligonucleotides may also cause degradation of unintended
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5852a56ae13fabda0113b0fcc3dafeb6
https://doi.org/10.1093/nar/gky397
https://doi.org/10.1093/nar/gky397
Autor:
Henrik Oerum, Marc Feldmann, Morten Lindow, Stefan Terlecki-Zaniewicz, David Ahern, Udo Oppermann, Pal Mander, Paul Bowness, Jeroen Baardman, Brante P. Sampey, Menno P.J. de Winther, Susanna Obad, Henry Penn, Adam P. Cribbs, Rab K. Prinjha, Paul Wordsworth, Martin Philpott
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 117(11), 6056-6066. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance T cells control many immune functions, with Th17 cells critical in regulating inflammation. Following activation, T cells undergo metabolic reprogramming and utilize glycolysis to increase the ATP availability. Epigenetic mechanisms cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36abcb281de6160ff914d6f5b8a2fa6
Publikováno v:
Nucleic Acids Research
Kiełpiński, Ł J, Hagedorn, P H, Lindow, M & Vinther, J 2017, ' RNase H sequence preferences influence antisense oligonucleotide efficiency ', Nucleic Acids Research, vol. 45, no. 22, pp. 12932-12944 . https://doi.org/10.1093/nar/gkx1073
Kiełpiński, Ł J, Hagedorn, P H, Lindow, M & Vinther, J 2017, ' RNase H sequence preferences influence antisense oligonucleotide efficiency ', Nucleic Acids Research, vol. 45, no. 22, pp. 12932-12944 . https://doi.org/10.1093/nar/gkx1073
RNase H cleaves RNA in RNA–DNA duplexes. It is present in all domains of life as well as in multiple viruses and is essential for mammalian development and for human immunodeficiency virus replication. Here, we developed a sequencing-based method t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0fd207eb3cfc2161fa9ee28d4a53aaf
https://pubmed.ncbi.nlm.nih.gov/29126318
https://pubmed.ncbi.nlm.nih.gov/29126318
Autor:
Yanping Feng, Jeppe Vinther, Jakob Lewin Rukov, Peter Hagedorn, Isabel Bro Høy, Morten Lindow
Publikováno v:
Rukov, J L, Hagedorn, P H, Høy, I B, Feng, Y, Lindow, M & Vinther, J 2015, ' Dissecting the target specificity of RNase H recruiting oligonucleotides using massively parallel reporter analysis of short RNA motifs ', Nucleic Acids Research, vol. 43, no. 17, pp. 8476-8487 . https://doi.org/10.1093/nar/gkv759
Nucleic Acids Research
Nucleic Acids Research
Processing and post-transcriptional regulation of RNA often depend on binding of regulatory molecules to short motifs in RNA. The effects of such interactions are difficult to study, because most regulatory molecules recognize partially degenerate RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a931fe5cd96bc61936b9ba1cb620285d
https://doi.org/10.1093/nar/gkv759
https://doi.org/10.1093/nar/gkv759
Autor:
Adam, Cribbs, Edward S, Hookway, Graham, Wells, Morten, Lindow, Susanna, Obad, Henrik, Oerum, Rab K, Prinjha, Nick, Athanasou, Aneka, Sowman, Martin, Philpott, Henry, Penn, Kalle, Soderstrom, Marc, Feldmann, Udo, Oppermann
Publikováno v:
The Journal of Biological Chemistry
Natural killer (NK) cells are innate lymphocytes, important in immune surveillance and elimination of stressed, transformed, or virus-infected cells. They critically shape the inflammatory cytokine environment to orchestrate interactions of cells of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::796dbca9b8091ba9eaec4cb53bb9fca5
https://pubmed.ncbi.nlm.nih.gov/29301935
https://pubmed.ncbi.nlm.nih.gov/29301935