Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Morten Lapin"'
Autor:
Karin Hestnes Edland, Kjersti Tjensvoll, Satu Oltedal, Ingvild Dalen, Morten Lapin, Herish Garresori, Nils Glenjen, Bjørnar Gilje, Oddmund Nordgård
Publikováno v:
Molecular Oncology, Vol 17, Iss 9, Pp 1857-1870 (2023)
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a need for better tools to guide treatment selection and follow‐up. The aim of this prospective study was to investigate the prognostic value and treatment monitoring potential of lon
Externí odkaz:
https://doaj.org/article/8e6c8d4f822b4c32bf88eedebcdef4ad
Autor:
Oddmund Nordgård, Morten Lapin, Kjersti Tjensvoll, Satu Oltedal, Karin Hestnes Edland, Nicolay Bore Neverdahl, Dmitrij Fostenes, Herish Garresori, Nils Glenjen, Rune Smaaland, Bjørnar Gilje
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Although pancreatic ductal adenocarcinoma (PDAC) rarely metastasizes to the skeleton, disseminated tumor cells have been detected in bone marrow samples from patients with this disease. The prognostic value of such findings is cur
Externí odkaz:
https://doaj.org/article/4aef64ca55384218b8d598fdaa28c2df
Autor:
Kjersti Tjensvoll, Morten Lapin, Bjørnar Gilje, Herish Garresori, Satu Oltedal, Rakel Brendsdal Forthun, Anders Molven, Yves Rozenholc, Oddmund Nordgård
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Circulating tumor DNA (ctDNA) analysis has emerged as a clinically useful tool for cancer diagnostics and treatment monitoring. However, ctDNA detection is complicated by low DNA concentrations and technical challenges. Here we describe our
Externí odkaz:
https://doaj.org/article/da1fe73c4390450aaa2f5f40ab495524
Autor:
Morten Lapin, Kjersti Tjensvoll, Karoline Nedrebø, Eline Taksdal, Hans Janssen, Bjørnar Gilje, Oddmund Nordgård
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0291623 (2023)
Tumor-derived extracellular vesicles (EVs) are reported to contain nucleic acids, including DNA. Several studies have highlighted the potential of EV-derived DNA (evDNA) as a circulating biomarker, even demonstrating that evDNA can outperform cell-fr
Externí odkaz:
https://doaj.org/article/45fe1e563349483fac4a692e3f388166
Autor:
Morten Lapin, Satu Oltedal, Kjersti Tjensvoll, Tove Buhl, Rune Smaaland, Herish Garresori, Milind Javle, Nils Idar Glenjen, Bente Kristin Abelseth, Bjørnar Gilje, Oddmund Nordgård
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-10 (2018)
Abstract Background It was recently demonstrated that the size of cell-free DNA (cfDNA) fragments that originates from tumor cells are shorter than cfDNA fragments that originates from non-malignant cells. We investigated whether cfDNA fragment size
Externí odkaz:
https://doaj.org/article/16325d71ccbc4d50a0c404e152588ca0
Autor:
Irene Tveiterås Øvestad, Birgit Engesæter, Mari Kyllesø Halle, Saleha Akbari, Beatrix Bicskei, Morten Lapin, Marie Austdal, Emiel A. M. Janssen, Camilla Krakstad, Melinda Lillesand, Marit Nordhus, Ane Cecilie Munk, Einar G. Gudlaugsson
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 373 (2021)
Implementation of high-risk human papilloma virus (HPV) screening and the increasing proportion of HPV vaccinated women in the screening program will reduce the percentage of HPV positive women with oncogenic potential. In search of more specific mar
Externí odkaz:
https://doaj.org/article/dfc7af310fef480c927fc548096075c1
Autor:
Morten Lapin, Kjersti Tjensvoll, Satu Oltedal, Milind Javle, Rune Smaaland, Bjørnar Gilje, Oddmund Nordgård
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-10 (2017)
Abstract Background Single-cell mRNA profiling of circulating tumour cells may contribute to a better understanding of the biology of these cells and their role in the metastatic process. In addition, such analyses may reveal new knowledge about the
Externí odkaz:
https://doaj.org/article/8c018f8ebd3f43e8bd039d3098ebb8c7
Autor:
Oddmund Nordgård, Rakel Brendsdal Forthun, Morten Lapin, Bjørn Henning Grønberg, Karl Henning Kalland, Reidun Kristin Kopperud, Liv Cecilie Vestrheim Thomsen, Kjersti Tjensvoll, Bjørnar Gilje, Bjørn Tore Gjertsen, Randi Hovland
Publikováno v:
Cancers, Vol 13, Iss 8, p 1861 (2021)
Liquid biopsies have emerged as a potential new diagnostic tool, providing detailed information relevant for characterization and treatment of solid cancers. We here present an overview of current evidence supporting the clinical relevance of liquid
Externí odkaz:
https://doaj.org/article/32e4560cba91410e911096a025c58064
Autor:
Anne-Mette Hartung, Jeff Swensen, Inaki E Uriz, Morten Lapin, Karen Kristjansdottir, Ulrika S S Petersen, Jeanne Mari V Bang, Barbara Guerra, Henriette Skovgaard Andersen, Steven F Dobrowolski, John C Carey, Ping Yu, Cecily Vaughn, Amy Calhoun, Martin R Larsen, Lars Dyrskjøt, David A Stevenson, Brage S Andresen
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006039 (2016)
Costello syndrome (CS) may be caused by activating mutations in codon 12/13 of the HRAS proto-oncogene. HRAS p.Gly12Val mutations have the highest transforming activity, are very frequent in cancers, but very rare in CS, where they are reported to ca
Externí odkaz:
https://doaj.org/article/1e346ab8d30947b8a0549231e917af6c
Autor:
Morten Lapin, Karin H. Edland, Kjersti Tjensvoll, Satu Oltedal, Marie Austdal, Herish Garresori, Yves Rozenholc, Bjørnar Gilje, Oddmund Nordgård
Publikováno v:
Clinical Cancer Research. 29:1267-1278
Purpose: Circulating tumor DNA (ctDNA) has emerged as a promising tumor-specific biomarker in pancreatic cancer, but current evidence of the clinical potential of ctDNA is limited. In this study, we used comprehensive detection methodology to explore