Zobrazeno 1 - 10 of 55 pro vyhledávání: '"Morten Kjeldgaard"'
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The Shapes of Z- α 1 -Antitrypsin Polymers in Solution Support the C-Terminal Domain-Swap Mechanism of Polymerization
Autor: James A. Huntington, Jan K. Jensen, Morten Kjeldgaard, Manja A. Behrens, Jan Skov Pedersen, Timothy J. Sendall
Publikováno v: Behrens, M A, Sendall, T J, Pedersen, J S, Kjeldgaard, M, Huntington, J A & Jensen, J K 2014, ' The Shapes of Z-α1-Antitrypsin Polymers in Solution Support the C-Terminal Domain-Swap Mechanism of Polymerization ', Biophysical Journal, vol. 107, no. 8, pp. 1905-1912 . https://doi.org/10.1016/j.bpj.2014.08.030
Emphysema and liver cirrhosis can be caused by the Z mutation (Glu342Lys) in the serine protease inhibitor α1-antitrypsin (α1AT), which is found in more than 4% of the Northern European population. Homozygotes experience deficiency in the lung conc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c7ba7c37caa5c56eb4d23281576676
https://doi.org/10.1016/j.bpj.2014.08.030
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5
Structural insights into the bacterial carbon - phosphorus lyase machinery
Autor: Christopher J. Russo, Paulina Seweryn, Lan Bich Van, Ditlev E. Brodersen, Bjarne Jochimsen, Bjarne Hove-Jensen, Morten Kjeldgaard, Lori A. Passmore
Publikováno v: Seweryn, P, Van, L B, Kjeldgaard, M, J. Russo, C, A. Passmore, L, Hove-Jensen, B, Jochimsen, B & Brodersen, D E 2015, ' Structural insights into the bacterial carbon-phosphorus lyase machinery ', Nature, vol. 525, pp. 68-72 . https://doi.org/10.1038/nature14683
Nature
Phosphorus is required for all life and microorganisms can extract it from their environment through several metabolic pathways. When phosphate is in limited supply, some bacteria are able to use phosphonate compounds, which require specialized enzym
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::442d898f909f4c14c0fd84605266f896
https://pure.au.dk/portal/da/publications/structural-insights-into-the-bacterial-carbon--phosphorus-lyase-machinery(0c2f68ac-d2c5-4012-b804-aafacd4333cd).html
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6
Recognition of Aminoacyl-tRNAs by Protein Elongation Factors
Autor: Mathias Sprinzl, Jan Barciszewski, Brian F.C. Clark, Morten Kjeldgaard
The interactive recognition of nucleic acids by proteins is a central process in the regulation of gene expression. To gain insight into such interactions requires a knowledge of appropriate three-dimensional structures and information on biochemical
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a45908c9e583e0f835a1add686f639e
https://doi.org/10.1128/9781555818333.ch21
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7
Ternary Complex of EF-Tu and Its Action on the Ribosome
Autor: Gregers R. Andersen, Morten Kjeldgaard, Søren Thirup, Jens Nyborg, Victor G. Stepanov
Publikováno v: The Ribosome
This chapter describes the advances made in the structural studies of elongation factor EF-Tu during the last decade, and shows that the structural transition between the active, aa-tRNA binding form and the inactive form of EF-Tu is surprisingly lar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f189c5cea1810ed53272b767a56e4216
https://doi.org/10.1128/9781555818142.ch27
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8
Applications of single-wavelength anomalous dispersion at high and atomic resolution
Autor: E. de la Fortelle, C. Vonrhein, Jens Nyborg, Morten Kjeldgaard, Gérard Bricogne, Ditlev E. Brodersen
Publikováno v: Brodersen, D E, Fortelle, E D L, Vohnrhein, C, Bricogne, G, Nyborg, J & Kjeldgaard, M 2006, ' Applications of single-wavelength anomalous dispersion at high and atomic resolution ', Acta Crystallographica. Section D: Biological Crystallography, bind D62, s. 1102 .
Aarhus University
Brodersen, D E, de La Fortelle, E, Vonrhein, C, Bricogne, G, Nyborg, J & Kjeldgaard, M 2000, ' Applications of single-wavelength anomalous dispersion at high and atomic resolution. ', Acta Crystallographica. Section D: Biological Crystallography, vol. 56, no. Pt 4, pp. 431-41 .
Udgivelsesdato: 2000-Apr Two examples of the application of single-wavelength anomalous dispersion (SAD) in macromolecular structure determination are described, both using the statistical phasing program SHARP. For the holmium-substituted calcium-bi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ecdc0b1dc44dc3475f0504f7de90a63
https://doi.org/10.1107/s0907444900000834
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9
Helix unwinding in the effector region of elongation factor EF-Tu–GDP
Autor: Corinna Lippmann, Poul Nissen, Morten Kjeldgaard, Søren Thirup, Galina Polekhina, Jens Nyborg
Publikováno v: Structure. 4:1141-1151
Background Elongation factor Tu (EF-Tu) in its GTP conformation is a carrier of aminoacylated tRNAs (aa-tRNAs) to the ribosomal A site during protein biosynthesis. The ribosome triggers GTP hydrolysis, resulting in the dissociation of EF-Tu–GDP fro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03cafe1844344031991ef1fbd007b58f
https://doi.org/10.1016/s0969-2126(96)00122-0
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10
The Unfolding Story of Polypeptide Release Factors
Autor: Morten Kjeldgaard
Publikováno v: Kjeldgaard, M 2003, ' The unfolding story of polypeptide release factors ', Mol. Cell., vol. 11, pp. 8-10 .
Two recent cryo-EM reconstructions of the ribosome-bound release factor RF2 reveal an open, tri-lobed shape of RF2, in contrast to the comma-shaped molecule seen in the crystal structure. This indicates that RF2 undergoes a conformational change upon
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