Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Morten H. Raadam"'
Autor:
Codruta Ignea, Morten H. Raadam, Aikaterini Koutsaviti, Yong Zhao, Yao-Tao Duan, Maria Harizani, Karel Miettinen, Panagiota Georgantea, Mads Rosenfeldt, Sara E. Viejo-Ledesma, Mikael A. Petersen, Wender L. P. Bredie, Dan Staerk, Vassilios Roussis, Efstathia Ioannou, Sotirios C. Kampranis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Establishing methods to access the chemical space that lies beyond canonical terpenoid biosynthesis will increase the applications of isoprenoids. Here, the authors reconstruct the modular structure of terpene biosynthesis on 16-carbon backbones by e
Externí odkaz:
https://doaj.org/article/a0bf4119487e4232a42a4065049f8276
Autor:
Aldo Almeida, Lemeng Dong, Theis H. Thorsen, Morten H. Raadam, Bekzod Khakimov, Natalia Carreno-Quintero, Sotirios C. Kampranis, Søren Bak
Publikováno v:
Frontiers in Plant Science, Vol 13 (2022)
In this paper we show that metabolic engineering in Cucurbita pepo hairy roots can be used to both effectively increase and modify cucurbitacins. Cucurbitacins are highly-oxygenated triterpenoids originally described in the Cucurbitaceae family, but
Externí odkaz:
https://doaj.org/article/e9b5e657ee2149f985cc1b2bfeb666ce
Autor:
Nikolaj L. Hansen, Karel Miettinen, Yong Zhao, Codruta Ignea, Aggeliki Andreadelli, Morten H. Raadam, Antonios M. Makris, Birger L. Møller, Dan Stærk, Søren Bak, Sotirios C. Kampranis
Publikováno v:
Microbial Cell Factories, Vol 19, Iss 1, Pp 1-17 (2020)
Abstract Background Celastrol is a promising anti-obesity agent that acts as a sensitizer of the protein hormone leptin. Despite its potent activity, a sustainable source of celastrol and celastrol derivatives for further pharmacological studies is l
Externí odkaz:
https://doaj.org/article/4893ec1389c84ef0a83e0925cf991ed9
Autor:
Codruta Ignea, Morten H. Raadam, Mohammed S. Motawia, Antonios M. Makris, Claudia E. Vickers, Sotirios C. Kampranis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Titers of monoterpenoids production in yeast are low due to the fact that the geranyl diphosphate (GPP)-based pathway can redirect metabolic fluxes to growth. Here, the authors build an orthogonal pathway by selecting the cis isomer of GPP as an alte
Externí odkaz:
https://doaj.org/article/5de8de4ce8a04318b1738fc8284a2b44
Autor:
Aldo Almeida, Morten H. Raadam, Adriana Lopez-Villanueva, Inty Omar Hernandez-De Lira, Bekzod Khakimov
Publikováno v:
BioEnergy Research. 16:898-911
Autor:
Sotirios C. Kampranis, Codruta Ignea, Antonios M. Makris, Mohammed Saddik Motawia, Claudia E. Vickers, Morten H. Raadam
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Ignea, C, Raadam, M H, Motawia, M S, Makris, A M, Vickers, C E & Kampranis, S C 2019, ' Orthogonal monoterpenoid biosynthesis in yeast constructed on an isomeric substrate ', Nature Communications, vol. 10 . https://doi.org/10.1038/s41467-019-11290-x
Nature Communications
Ignea, C, Raadam, M H, Motawia, M S, Makris, A M, Vickers, C E & Kampranis, S C 2019, ' Orthogonal monoterpenoid biosynthesis in yeast constructed on an isomeric substrate ', Nature Communications, vol. 10 . https://doi.org/10.1038/s41467-019-11290-x
Nature Communications
Synthetic biology efforts for the production of valuable chemicals are frequently hindered by the structure and regulation of the native metabolic pathways of the chassis. This is particularly evident in the case of monoterpenoid production in Saccha
Autor:
Søren Bak, Yong Zhao, Sotirios C. Kampranis, Karel Miettinen, Antonios M. Makris, Aggeliki Andreadelli, Nikolaj Lervad Hansen, Dan Staerk, Morten H. Raadam, Codruta Ignea, Birger Lindberg Møller
Publikováno v:
Microbial Cell Factories
Microbial Cell Factories, Vol 19, Iss 1, Pp 1-17 (2020)
Hansen, N L, Miettinen, K, Zhao, Y, Ignea, C, Andreadeli, A, Raadam, M H, Makris, A M, Møller, B L, Stærk, D, Bak, S & Kampranis, S 2020, ' Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol ', Microbial Cell Factories, vol. 19, 15 . https://doi.org/10.1186/s12934-020-1284-9
Microbial Cell Factories, Vol 19, Iss 1, Pp 1-17 (2020)
Hansen, N L, Miettinen, K, Zhao, Y, Ignea, C, Andreadeli, A, Raadam, M H, Makris, A M, Møller, B L, Stærk, D, Bak, S & Kampranis, S 2020, ' Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol ', Microbial Cell Factories, vol. 19, 15 . https://doi.org/10.1186/s12934-020-1284-9
Background Celastrol is a promising anti-obesity agent that acts as a sensitizer of the protein hormone leptin. Despite its potent activity, a sustainable source of celastrol and celastrol derivatives for further pharmacological studies is lacking. R