Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Morten Grøtli"'
Autor:
Sunniva Sigurdardóttir, Suélen Fernandes Silva, Ievgeniia Tiukova, Hanna Alalam, Ross D. King, Morten Grøtli, Leif A. Eriksson, Per Sunnerhagen
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 10 (2024)
ABSTRACT The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus continues to cause severe disease and deaths in many parts of the world, despite massive vaccination efforts. Antiviral drugs to curb an ongoing infection remain a priori
Externí odkaz:
https://doaj.org/article/78eed8274ce84aa2812953c0557ee2e6
Autor:
Diego Rodríguez-Hernández, Kamalakannan Vijayan, Rachael Zigweid, Michael K. Fenwick, Banumathi Sankaran, Wanlapa Roobsoong, Jetsumon Sattabongkot, Elizabeth K. K. Glennon, Peter J. Myler, Per Sunnerhagen, Bart L. Staker, Alexis Kaushansky, Morten Grøtli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Drugs targeting multiple stages of the Plasmodium vivax life cycle are needed to reduce the health and economic burdens caused by malaria worldwide. N-myristoyltransferase (NMT) is an essential eukaryotic enzyme and a validated drug target f
Externí odkaz:
https://doaj.org/article/e6b4e2ed37a24eb3abab00e4f5cd5476
Autor:
Mattias Bood, Anna Wypijewska del Nogal, Jesper R. Nilsson, Fredrik Edfeldt, Anders Dahlén, Malin Lemurell, L. Marcus Wilhelmsson, Morten Grøtli
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The aberrant expression of microRNAs (miRs) has been linked to several human diseases. A promising approach for targeting these anomalies is the use of small-molecule inhibitors of miR biogenesis. These inhibitors have the potential to (i) d
Externí odkaz:
https://doaj.org/article/cda9c7e7160e4417b694ff5cf0c29da7
Autor:
Umberto Maria Battisti, Leticia Monjas, Fady Akladios, Josipa Matic, Eric Andresen, Carolin H. Nagel, Malin Hagkvist, Liliana Håversen, Woonghee Kim, Mathias Uhlen, Jan Borén, Adil Mardinoğlu, Morten Grøtli
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 668 (2023)
The inhibition of liver pyruvate kinase could be beneficial to halt or reverse non-alcoholic fatty liver disease (NAFLD), a progressive accumulation of fat in the liver that can lead eventually to cirrhosis. Recently, urolithin C has been reported as
Externí odkaz:
https://doaj.org/article/030b7f82a2c046bcb5af2aeb60b25820
Autor:
Hanna Alalam, Sunniva Sigurdardóttir, Catarina Bourgard, Ievgeniia Tiukova, Ross D. King, Morten Grøtli, Per Sunnerhagen
Publikováno v:
mSystems, Vol 6, Iss 6 (2021)
ABSTRACT The ongoing COVID-19 pandemic urges searches for antiviral agents that can block infection or ameliorate its symptoms. Using dissimilar search strategies for new antivirals will improve our overall chances of finding effective treatments. He
Externí odkaz:
https://doaj.org/article/8f15a8dbbb7e4255b1124284a13c6d43
Autor:
Catarina Bourgard, Diego Rodríguez-Hernández, Anastasia Rudenko, Carolin Rutgersson, Martin Palm, D. G. Joakim Larsson, Anne Farewell, Morten Grøtli, Per Sunnerhagen
Publikováno v:
Antibiotics, Vol 11, Iss 8, p 1115 (2022)
Antibiotic resistance among bacteria is a growing global challenge. A major reason for this is the limited progress in developing new classes of antibiotics active against Gram-negative bacteria. Here, we investigate the antibacterial activity of a d
Externí odkaz:
https://doaj.org/article/b6d8f6bfd3ad477782fba0387134da4d
Autor:
Friederike Roger, Cecilia Picazo, Wolfgang Reiter, Marouane Libiad, Chikako Asami, Sarah Hanzén, Chunxia Gao, Gilles Lagniel, Niek Welkenhuysen, Jean Labarre, Thomas Nyström, Morten Grøtli, Markus Hartl, Michel B Toledano, Mikael Molin
Publikováno v:
eLife, Vol 9 (2020)
Peroxiredoxins are H2O2 scavenging enzymes that also carry out H2O2 signaling and chaperone functions. In yeast, the major cytosolic peroxiredoxin, Tsa1 is required for both promoting resistance to H2O2 and extending lifespan upon caloric restriction
Externí odkaz:
https://doaj.org/article/7b5d8c65106d424db0c6df46c7b60c1a
Autor:
Christopher P. Lawson, Anders F. Füchtbauer, Moa S. Wranne, Tristan Giraud, Thomas Floyd, Blaise Dumat, Nicolai K. Andersen, Afaf H. El-Sagheer, Tom Brown, Henrik Gradén, L. Marcus Wilhelmsson, Morten Grøtli
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract Fluorescent base analogues (FBAs) have emerged as a powerful class of molecular reporters of location and environment for nucleic acids. In our overall mission to develop bright and useful FBAs for all natural nucleobases, herein we describe
Externí odkaz:
https://doaj.org/article/91467726e61f4f76abb1785ce4f6f727
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 114-129 (2018)
Förster resonance energy transfer (FRET) between a donor nucleobase analogue and an acceptor nucleobase analogue, base–base FRET, works as a spectroscopic ruler and protractor. With their firm stacking and ability to replace the natural nucleic ac
Externí odkaz:
https://doaj.org/article/d356d7533aff4d8ab3ddd02f0ca5e348
Autor:
Sunjae Lee, Cheng Zhang, Zhengtao Liu, Martina Klevstig, Bani Mukhopadhyay, Mattias Bergentall, Resat Cinar, Marcus Ståhlman, Natasha Sikanic, Joshua K Park, Sumit Deshmukh, Azadeh M Harzandi, Tim Kuijpers, Morten Grøtli, Simon J Elsässer, Brian D Piening, Michael Snyder, Ulf Smith, Jens Nielsen, Fredrik Bäckhed, George Kunos, Mathias Uhlen, Jan Boren, Adil Mardinoglu
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 8, Pp 1-15 (2017)
Abstract We performed integrative network analyses to identify targets that can be used for effectively treating liver diseases with minimal side effects. We first generated co‐expression networks (CNs) for 46 human tissues and liver cancer to expl
Externí odkaz:
https://doaj.org/article/d25cec84bc19451aa968b418e06ff71b