Supplementary Tables 1 and 2 from Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition of CXCR4 and Hedgehog Signaling

Autor: Christopher Heeschen, Mert Erkan, Joerg Kleeff, Manuel Hidalgo, Irene Miranda-Lorenzo, Catarina R. Vieira, Michele Cioffi, Bruno Sainz, Sara Maria Trabulo, Morten Dræby Sørensen, Anamaria Balic

PDF - 48K, Table S1. List of utilized primers. Table S2. List of utilized antibodies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239b01958abb3b356a6cab145fb6699e
https://doi.org/10.1158/1535-7163.22500090

Supplementary Figures 1 through 6 from Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition of CXCR4 and Hedgehog Signaling

Autor: Christopher Heeschen, Mert Erkan, Joerg Kleeff, Manuel Hidalgo, Irene Miranda-Lorenzo, Catarina R. Vieira, Michele Cioffi, Bruno Sainz, Sara Maria Trabulo, Morten Dræby Sørensen, Anamaria Balic

PDF - 3180K, Figure S1. Chloroquine does not affect differentiated cancer cells. Figure S2. Chloroquine eliminates pancreatic cancer stem cells. Figure S3. Autophagy is not mediating the effect of chloroquine on primary PDAC cells. Figure S4. Chloroq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5633bb70ef8c7c403555618b1186355a
https://doi.org/10.1158/1535-7163.22500096

Chloroquine Targets Pancreatic Cancer Stem Cells via Inhibition of CXCR4 and Hedgehog Signaling

Autor: Catarina R. Vieira, Christopher Heeschen, Sara Trabulo, Michele Cioffi, Bruno Sainz, Irene Miranda-Lorenzo, J. Kleeff, Mert Erkan, Morten Dræby Sørensen, Manuel Hidalgo, Anamaria Balic

Publikováno v: Molecular Cancer Therapeutics
Molecular Cancer Therapeutics; Vol 13
Balic, A, Sørensen, M D, Trabulo, S M, Sainz Jr., B, Cioffi, M, Vieira, C, Miranda-Lorenzo, I, Hidalgo, M, Kleeff, J, Erkan, M & Heeschen, C 2014, ' Chloroquine targets pancreatic cancer stem cells via inhibition of CXCR4 and hedgehog signaling ', Molecular Cancer Therapeutics, vol. 13, no. 7, pp. 1758–1771 . https://doi.org/10.1158/1535-7163.MCT-13-0948

Pancreatic ductal adenocarcinoma is one of the deadliest carcinomas and is characterized by highly tumorigenic and metastatic cancer stem cells (CSC). CSCs evade available therapies, which preferentially target highly proliferative and more different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9570fc6ab95175d31559f1fd68635cff

A phase I study of the safety and pharmacokinetics of the histone deacetylase inhibitor belinostat administered in combination with carboplatin and/or paclitaxel in patients with solid tumours

Autor: Poul Knoblauch, Elizabeth Crowley, J.S. de Bono, J. Tjornelund, Rajesh Sinha, Laura Vidal, Richard T. Penson, Morten Dræby Sørensen, P. Buhl-Jensen, L. R. Molife, Ulrik Lassen, S-A Engelholm

Publikováno v: British Journal of Cancer

Background: This phase I study assessed the maximum tolerated dose, dose-limiting toxicity (DLT) and pharmacokinetics of belinostat with carboplatin and paclitaxel and the anti-tumour activity of the combination in solid tumours. Methods: Cohorts of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7de1324b869064e3acccbbf74ef36c6
https://doi.org/10.1038/sj.bjc.6605726

Severe Acute Respiratory Syndrome (SARS): Development of Diagnostics and Antivirals

Autor: Regina Gonzalez-Dosal, Connie Jenning Melchjorsen, Jens Weibel, Yang Huan-ming, B. S. Sørensen, Peter Kristensen, Morten Dræby Sørensen, Chen Wie Jun, Jing Wang

Publikováno v: Annals of the New York Academy of Sciences. 1067:500-505

The previously unknown coronavirus that caused severe acute respiratory syndrome (SARS-CoV) affected more than 8,000 persons worldwide and was responsible for more than 700 deaths during the first outbreak in 2002-2003. For reasons unknown, the SARS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b1a2bf8e388ed9cbb56d8785569800b
https://doi.org/10.1196/annals.1354.072