Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Morten Brændvang"'
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:6512-6516
6-Benzofuryl-, styryl, benzyl, and furfurylpurines as well as 6-[1(3H)-isobenzofuranylidenemethyl]purines have been synthesized and their activities against Mycobacterium tuberculosis (Mtb) determined. Several compounds displayed profound antimycobac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33acdadc7b009fb551613ebacc8412ab
https://doi.org/10.1016/j.bmc.2009.08.012
https://doi.org/10.1016/j.bmc.2009.08.012
Publikováno v:
Tetrahedron. 65:194-199
Agelasine F has previously been isolated from marine sponges (Agelas sp.) and has been associated with various bioactivities including inhibitory activity on Mycobacterium tuberculosis. No total synthesis of this natural product has been reported. en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ad1e8e5847143d622782f5ed9ab9a83
https://doi.org/10.1016/j.tet.2008.10.081
https://doi.org/10.1016/j.tet.2008.10.081
Autor:
Morten Brændvang, Lise-Lotte Gundersen
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:6360-6373
6-Aryl- and 6-heteroaryl-9-benzylpurines have been synthesized employing palladium-catalyzed coupling reactions in the step forming the C-C or C-N bond between the aryl- or heteroaryl and the purine. The compounds were screened for activity against M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b66700937be2fbe1fc8f40c69a4e2c1
https://doi.org/10.1016/j.bmc.2005.06.054
https://doi.org/10.1016/j.bmc.2005.06.054
Autor:
Morten Brændvang, Lise-Lotte Gundersen
Publikováno v:
Acta Crystallographica Section C Crystal Structure Communications. 63:o274-o276
The title compound, C(17)H(13)ClN(4)O(2), displays profound and selective activity against Mycobacterium tuberculosis. In the crystal structure, there are two independent molecules in the asymmetric unit. Intermolecular hydrogen bonding between a CH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955738382a35abc517a7993c04b1bf94
https://doi.org/10.1107/s0108270107011596
https://doi.org/10.1107/s0108270107011596
Autor:
Lise-Lotte Gundersen, Morten Brændvang
Publikováno v:
Synthesis. 2006:2993-2995
A novel method for the introduction of fluorine in the purine 2-position is described and employed in the synthesis of a potential antimycobacterial compound. Also 2-fluoroadenosine has been synthesized for the first time from adenosine with perbenzo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f31bc767a5c65d6c15cdf6e0c1929e99
https://doi.org/10.1055/s-2006-942544
https://doi.org/10.1055/s-2006-942544
Publikováno v:
Bioorganicmedicinal chemistry. 18(11)
Pyrimidine analogs of antimycobacterial 6-aryl-9-benzylpurines have been synthesized and screened for antibacterial activity against Mycobacterium tuberculosis H 37 Rv in vitro. Several active compounds were identified and the best results were obser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46acfed113a75a31086130651a215f53
https://pubmed.ncbi.nlm.nih.gov/20488716
https://pubmed.ncbi.nlm.nih.gov/20488716
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(12)
Pyrimidine analogs of antimycobacterial purines have been synthesized and their biological activities evaluated. Several 5-formamidopyrimidines exhibited profound activity against Mycobacterium tuberculosis in vitro (IC90 ⩽ 1.5 μg/mL), and they we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb9bf5225c0a0b319f0b8a4758da1677
https://pubmed.ncbi.nlm.nih.gov/19427200
https://pubmed.ncbi.nlm.nih.gov/19427200
Autor:
Morten Brændvang, Lise-Lotte Gundersen
Publikováno v:
ChemInform. 38
Efficient and N-1 selective alkylation of 4-chloropyrazolo[3,4-d]pyrimidine can be achieved when the heterocycle is reacted with alcohols under Mitsunobu conditions. The 1-alkyl-pyrazolo[3,4-d]pyrimidines formed can be functionalized further accordin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c2e5275812141d91a3f5eb5dc7356f
https://doi.org/10.1002/chin.200733146
https://doi.org/10.1002/chin.200733146
Autor:
Morten Brændvang, Lise-Lotte Gundersen
Publikováno v:
Bioorganicmedicinal chemistry. 15(22)
A number of 6-(2-furyl)-9-(p-methoxybenzyl)purines carrying a variety of substituents in the 2- or 8-position have been synthesized and their ability to inhibit growth of Mycobacterium tuberculosis in vitro has been determined. It is demonstrated tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d616679c218d44b61c10a457697d1fea
https://pubmed.ncbi.nlm.nih.gov/17804243
https://pubmed.ncbi.nlm.nih.gov/17804243
