Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Morten B. Hansen"'
1
Akademický článek
Quantifying the transport of biologics across intestinal barrier models in real-time by fluorescent imaging
Autor: Arjen Weller, Morten B. Hansen, Rodolphe Marie, Adam C. Hundahl, Casper Hempel, Paul J. Kempen, Henrik L. Frandsen, Ladan Parhamifar, Jannik B. Larsen, Thomas L. Andresen
Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Unsuccessful clinical translation of orally delivered biological drugs remains a challenge in pharmaceutical development and has been linked to insufficient mechanistic understanding of intestinal drug transport. Live cell imaging could provide such
Externí odkaz: https://doaj.org/article/e425fcb8956a43f1a5293643c45fd42a
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2
Akademický článek
Interleukin‐6 signaling requires only few IL‐6 molecules: Relation to physiological concentrations of extracellular IL‐6
Autor: Morten B. Hansen
Publikováno v: Immunity, Inflammation and Disease, Vol 8, Iss 2, Pp 170-180 (2020)
Abstract Introduction The aim of this study was to give quantitative insight into the number of cytokine molecules needed to activate a target cell and relate this to the physiological consequences of the amounts of cytokines typically detectable in
Externí odkaz: https://doaj.org/article/23ee0424e3ce473c9545a676c175adc2
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3
Quantitative live-cell imaging of lipidated peptide transport through an epithelial cell layer
Autor: Adam Coln Hundahl, Arjen Weller, Jannik Bruun Larsen, Claudia U. Hjørringgaard, Morten B. Hansen, Ann-Kathrin Mündler, Astrid Knuhtsen, Kasper Kristensen, Eva C. Arnspang, Thomas Lars Andresen, Kim I. Mortensen, Rodolphe Marie
Publikováno v: Hundahl, A C, Weller, A, Larsen, J B, Hjørringgaard, C U, Hansen, M B, Mündler, A K, Knuhtsen, A, Kristensen, K, Arnspang, E C, Andresen, T L, Mortensen, K I & Marie, R 2023, ' Quantitative live-cell imaging of lipidated peptide transport through an epithelial cell layer ', Journal of controlled release, vol. 355, pp. 122-134 . https://doi.org/10.1016/j.jconrel.2023.01.066
Oral drug delivery increases patient compliance and is thus the preferred administration route for most drugs. However, for biologics the intestinal barrier greatly limits the absorption and reduces their bioavailability. One strategy employed to imp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f24fbd7b43ef2c7d24419183ef3ed8d0
https://orbit.dtu.dk/en/publications/49a97b83-ccf3-4061-af2e-604aecca20ff
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4
Which factors are associated with COVID-19 infection incidence in care services for older people in Nordic countries? A cross-sectional survey
Autor: Auvo S. Rauhala, Lisbeth M. Fagerström, Andrej C. Lindholst, Timo S. Sinervo, Tilde M. Bertelsen, Trond Bliksvær, Bente V. Lunde, Rolf Solli, Maria G. Wolmesjö, Morten B. Hansen
Publikováno v: Scandinavian Journal of Public Health
Rauhala, A, Fagerström, L, Lindholst, A C, Sinervo, T, Bertelsen, T M, Bliksvær, T, Lunde, B V, Solli, R, Wolmesjö, M & Hansen, M B 2022, ' Which factors are associated with COVID-19 infection incidence in care services for older people in Nordic countries? A cross-sectional survey ', Scandinavian Journal of Public Health, vol. 50, no. 6, pp. 787-794 . https://doi.org/10.1177/14034948221085398
Aims: To investigate the differences between Sweden, Denmark, Finland and Norway regarding residential/home care units’ and frontline managers’ background factors, the resources allocated and measures taken during the initial phases of the COVID-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab0abd77b05af0388c231dbb5886934c
https://hdl.handle.net/11250/3016475
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5
Akademický článek
Results of Automated Retinal Image Analysis for Detection of Diabetic Retinopathy from the Nakuru Study, Kenya.
Autor: Morten B Hansen, Michael D Abràmoff, James C Folk, Wanjiku Mathenge, Andrew Bastawrous, Tunde Peto
Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0139148 (2015)
OBJECTIVE:Digital retinal imaging is an established method of screening for diabetic retinopathy (DR). It has been established that currently about 1% of the world's blind or visually impaired is due to DR. However, the increasing prevalence of diabe
Externí odkaz: https://doaj.org/article/c93f05ce641f4fe489c3bf31898329fa
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6
Applying flow cytometry to identify the modes of action of membrane-active peptides in a label-free and high-throughput fashion
Autor: Nanna Wichmann, Jens B. Simonsen, Kasper Kristensen, Jannik B. Larsen, Philip M. Lund, Thomas Lars Andresen, Claudia U. Hjørringgaard, Morten B. Hansen
Publikováno v: Wichmann, N, Lund, P M, Hansen, M B, Hjørringgaard, C U, Larsen, J B, Kristensen, K, Andresen, T L & Simonsen, J B 2021, ' Applying flow cytometry to identify the modes of action of membrane-active peptides in a label-free and high-throughput fashion ', B B A-Biomembranes, vol. 864, no. 2, 183820 . https://doi.org/10.1016/j.bbamem.2021.183820
Membrane-active peptides (MAPs) have several potential therapeutic uses, including as antimicrobial drugs. Many traditional methods used to evaluate the membrane interactions of MAPs have limited applicability. Low-throughput methods, such as microsc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fc00c02354ff323e22327618c824ab
https://doi.org/10.1016/j.bbamem.2021.183820
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7
Functionalization of 2″-C-(Piperazinomethyl)-2′,3′-BcNA (Bicyclic Nucleic Acids) with Pyren-1-ylcarbonyl Units
Autor: Michael Raunkjaer, Nicolai Krog Andersen, Morten B. Hansen, Jesper Wengel, Per T. Jørgensen
Publikováno v: Hansen, M B, Andersen, N K, Raunkjær, M, Jørgensen, P T & Wengel, J 2014, ' Functionalization of 2’’-C-(piperazinomethyl)-2’,3’-BcNA (bicyclic nucleic acids) with pyren-1-ylcarbonyl units ', Helvetica Chimica Acta, vol. 97, no. 9, pp. 1204-1218 . https://doi.org/10.1002/hlca.201400141
Herein, we describe the incorporation of 2″-C-(piperazinomethyl)-2′,3′-BcNA (Bicyclic Nucleic Acids) into oligonucleotides via phosphoramidite chemistry and their subsequent solid-phase functionalization with pyren-1-ylcarbonyl units after olig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414445ec09b977e3d91230d5cac0cf17
https://doi.org/10.1002/hlca.201400141
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9
Enzyme-Activatable Cell-Penetrating Peptides through a Minimal Side Chain Modification
Autor: Dennis W. P. M. Löwik, S.A. Bode, Morten B. Hansen, Jan C. M. van Hest, Roy A. J. F. Oerlemans
Publikováno v: Bioconjugate Chemistry, 26, 850-856
Bioconjugate Chemistry, 26, 5, pp. 850-856
Activatable cell-penetrating peptides are of great interest in drug delivery because of their enhanced selectivity which can be controlled by the external stimuli that trigger their activation. The use of a specific enzymatic reaction to trigger upta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdd726ad5cfa6f1b510bae9ea2d0085b
http://hdl.handle.net/2066/144935
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10
Quick-and-easy preparation and purification of quantum dot-loaded liposomes
Autor: Clara van Emmerik, Morten B. Hansen, Ethlinn V.B. van Gaal, Dennis W. P. M. Löwik, Jan C. M. van Hest, Gert Storm
Publikováno v: Journal of nanoparticle research, 15(1):1340. Springer
Quantum dots are very attractive as fluorescent markers because of their excellent optical properties. For this reason, they have also been used to label liposomes by means of encapsulation, though their feasibility as liposome labels is often hamper
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0c273621fe072b579665c085b71857
https://research.utwente.nl/en/publications/8e694efc-cae1-40f8-957d-49ae92bb90c3
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