Quantitative proteome comparison of human hearts with those of model organisms.

Autor: Nora Linscheid, Alberto Santos, Pi Camilla Poulsen, Robert W Mills, Kirstine Calloe, Ulrike Leurs, Johan Z Ye, Christian Stolte, Morten B Thomsen, Bo H Bentzen, Pia R Lundegaard, Morten S Olesen, Lars J Jensen, Jesper V Olsen, Alicia Lundby

Publikováno v: PLoS Biology, Vol 19, Iss 4, p e3001144 (2021)

Delineating human cardiac pathologies and their basic molecular mechanisms relies on research conducted in model organisms. Yet translating findings from preclinical models to humans present a significant challenge, in part due to differences in card

Externí odkaz: https://doaj.org/article/803278d7d2314c97a5198af5d5449f9c

The transport function of the human lymphatic system—A systematic review

Autor: Lene Thorup, Anders Hjortdal, Donna B. Boedtkjer, Morten B. Thomsen, Vibeke Hjortdal

Publikováno v: Physiological Reports, Vol 11, Iss 11, Pp n/a-n/a (2023)

Abstract Physiological properties and function of the lymphatic system is still somewhat of a mystery. We report the current knowledge about human lymphatic vessel contractility and capability of adaptation. A literature search in PubMed identified s

Externí odkaz: https://doaj.org/article/3f93971b496642b09c180d8a8863d158

Augmented Ouabain-Induced Vascular Response Reduces Cardiac Efficiency in Mice with Migraine-Associated Mutation in the Na+, K+-ATPase α2-Isoform

Autor: Rajkumar Rajanathan, Tina Myhre Pedersen, Halvor Osterby Guldbrandsen, Lenette Foldager Olesen, Morten B. Thomsen, Hans Erik Bøtker, Vladimir V. Matchkov

Publikováno v: Rajanathan, R, Pedersen, T M, Guldbrandsen, H O, Olesen, L F, Thomsen, M B, Bøtker, H E & Matchkov, V V 2023, ' Augmented Ouabain-Induced Vascular Response Reduces Cardiac Efficiency in Mice with Migraine-Associated Mutation in the Na +, K +-ATPase α 2-Isoform ', Biomedicines, vol. 11, no. 2, 344 . https://doi.org/10.3390/biomedicines11020344
Biomedicines
Volume 11
Issue 2
Pages: 344

Heterozygous mice (α2+/G301R mice) for the migraine-associated mutation (G301R) in the Na+,K+-ATPase α2-isoform have decreased expression of cardiovascular α2-isoform. The α2+/G301R mice exhibit a pro-contractile vascular phenotype associated wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ecef5f1f7efd850f0c11e309bfc45fd
https://pure.au.dk/portal/da/publications/augmented-ouabaininduced-vascular-response-reduces-cardiac-efficiency-in-mice-with-migraineassociated-mutation-in-the-na-katpase-2isoform(ced1ba32-45d1-4a7f-acd6-50e36cc30c34).html

Hypercontractile Cardiac Phenotype in Mice with Migraine-Associated Mutation in the Na+,K+-ATPase α2-Isoform

Autor: Rajkumar Rajanathan, Clàudia Vilaseca i Riera, Tina Myhre Pedersen, Christian Staehr, Elena V. Bouzinova, Jens Randel Nyengaard, Morten B. Thomsen, Hans Erik Bøtker, Vladimir V. Matchkov

Publikováno v: Cells; Volume 12; Issue 8; Pages: 1108
Rajanathan, R, Riera, C V I, Pedersen, T M, Staehr, C, Bouzinova, E V, Nyengaard, J R, Thomsen, M B, Bøtker, H E & Matchkov, V V 2023, ' Hypercontractile Cardiac Phenotype in Mice with Migraine-Associated Mutation in the Na +,K +-ATPase α 2-Isoform ', Cells, vol. 12, no. 8, 1108 . https://doi.org/10.3390/cells12081108
Rajanathan, R, Riera, C V I, Pedersen, T M, Staehr, C, Bouzinova, E V, Nyengaard, J R, Thomsen, M B, Bøtker, H E & Matchkov, V V 2023, ' Hypercontractile Cardiac Phenotype in Mice with Migraine-Associated Mutation in the Na+,K+-ATPase α2-Isoform ', Cells, vol. 12, no. 8 . https://doi.org/10.3390/cells12081108

Two α-isoforms of the Na+,K+-ATPase (α1 and α2) are expressed in the cardiovascular system, and it is unclear which isoform is the preferential regulator of contractility. Mice heterozygous for the familial hemiplegic migraine type 2 (FHM2) associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c0adcb122754676be550705fec0575
https://doi.org/10.3390/cells12081108

Phenylephrine-Induced Cardiovascular Changes in the Anesthetized Mouse:An Integrated Assessment of in vivo Hemodynamics Under Conditions of Controlled Heart Rate

Autor: Rajkumar Rajanathan, Tina Myhre Pedersen, Morten B. Thomsen, Hans Erik Botker, Vladimir V. Matchkov

Publikováno v: Rajanathan, R, Pedersen, T M, Thomsen, M B, Botker, H E & Matchkov, V V 2022, ' Phenylephrine-Induced Cardiovascular Changes in the Anesthetized Mouse : An Integrated Assessment of in vivo Hemodynamics Under Conditions of Controlled Heart Rate ', Frontiers in Physiology, vol. 13, 831724 . https://doi.org/10.3389/fphys.2022.831724
Frontiers in Physiology, Vol 13 (2022)

ObjectiveInvestigating the cardiovascular system is challenging due to its complex regulation by humoral and neuronal factors. Despite this complexity, many existing research methods are limited to the assessment of a few parameters leading to an inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2038c60b456cbfac8b3ddc94ff93518
https://pure.au.dk/portal/da/publications/phenylephrineinduced-cardiovascular-changes-in-the-anesthetized-mouse(b56e687b-6f1d-4d09-a017-8914f83b94f7).html