Zobrazeno 1 - 10 of 85 pro vyhledávání: '"Morten B, Thomsen"'
1
Akademický článek
The transport function of the human lymphatic system—A systematic review
Autor: Lene Thorup, Anders Hjortdal, Donna B. Boedtkjer, Morten B. Thomsen, Vibeke Hjortdal
Publikováno v: Physiological Reports, Vol 11, Iss 11, Pp n/a-n/a (2023)
Abstract Physiological properties and function of the lymphatic system is still somewhat of a mystery. We report the current knowledge about human lymphatic vessel contractility and capability of adaptation. A literature search in PubMed identified s
Externí odkaz: https://doaj.org/article/3f93971b496642b09c180d8a8863d158
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2
Akademický článek
Beta-blocker/ACE inhibitor therapy differentially impacts the steady state signaling landscape of failing and non-failing hearts
Autor: Andrea Sorrentino, Navratan Bagwan, Nora Linscheid, Pi C. Poulsen, Konstantin Kahnert, Morten B. Thomsen, Mario Delmar, Alicia Lundby
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Heart failure is a multifactorial disease that affects an estimated 38 million people worldwide. Current pharmacotherapy of heart failure with reduced ejection fraction (HFrEF) includes combination therapy with angiotensin-converting enzyme
Externí odkaz: https://doaj.org/article/b4f44776b48f459db91c12efe0d4d611
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3
Akademický článek
Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V
Autor: Anniek F. Lubberding, Jinyi Zhang, Morten Lundh, Thomas Svava Nielsen, Mathilde S. Søndergaard, Maria Villadsen, Emil Z. Skovhøj, Geke A. Boer, Jakob B. Hansen, Morten B. Thomsen, Jonas T. Treebak, Jens J. Holst, Jørgen K. Kanters, Thomas Mandrup-Poulsen, Thomas Jespersen, Brice Emanuelli, Signe S. Torekov
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Loss-of-function (LoF) mutations in KCNQ1, encoding the voltage-gated K+ channel Kv7.1, lead to long QT syndrome 1 (LQT1). LQT1 patients also present with post-prandial hyperinsulinemia and hypoglycaemia. In contrast, KCNQ1 polymorphisms are
Externí odkaz: https://doaj.org/article/bdb0c435470a478696e2cc00273a4925
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4
Akademický článek
Hypercontractile Cardiac Phenotype in Mice with Migraine-Associated Mutation in the Na+,K+-ATPase α2-Isoform
Autor: Rajkumar Rajanathan, Clàudia Vilaseca i Riera, Tina Myhre Pedersen, Christian Staehr, Elena V. Bouzinova, Jens Randel Nyengaard, Morten B. Thomsen, Hans Erik Bøtker, Vladimir V. Matchkov
Publikováno v: Cells, Vol 12, Iss 8, p 1108 (2023)
Two α-isoforms of the Na+,K+-ATPase (α1 and α2) are expressed in the cardiovascular system, and it is unclear which isoform is the preferential regulator of contractility. Mice heterozygous for the familial hemiplegic migraine type 2 (FHM2) associ
Externí odkaz: https://doaj.org/article/83c10daa4fff495291a49f27e0bf5151
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5
Akademický článek
Phenylephrine-Induced Cardiovascular Changes in the Anesthetized Mouse: An Integrated Assessment of in vivo Hemodynamics Under Conditions of Controlled Heart Rate
Autor: Rajkumar Rajanathan, Tina Myhre Pedersen, Morten B. Thomsen, Hans Erik Botker, Vladimir V. Matchkov
Publikováno v: Frontiers in Physiology, Vol 13 (2022)
ObjectiveInvestigating the cardiovascular system is challenging due to its complex regulation by humoral and neuronal factors. Despite this complexity, many existing research methods are limited to the assessment of a few parameters leading to an inc
Externí odkaz: https://doaj.org/article/f1626725308f43bb9825ff274abac5a5
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6
Akademický článek
Augmented Ouabain-Induced Vascular Response Reduces Cardiac Efficiency in Mice with Migraine-Associated Mutation in the Na+, K+-ATPase α2-Isoform
Autor: Rajkumar Rajanathan, Tina Myhre Pedersen, Halvor Osterby Guldbrandsen, Lenette Foldager Olesen, Morten B. Thomsen, Hans Erik Bøtker, Vladimir V. Matchkov
Publikováno v: Biomedicines, Vol 11, Iss 2, p 344 (2023)
Heterozygous mice (α2+/G301R mice) for the migraine-associated mutation (G301R) in the Na+,K+-ATPase α2-isoform have decreased expression of cardiovascular α2-isoform. The α2+/G301R mice exhibit a pro-contractile vascular phenotype associated wit
Externí odkaz: https://doaj.org/article/2eec613c5ccb45259ca1f9314989d331
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7
Akademický článek
Quantitative proteome comparison of human hearts with those of model organisms.
Autor: Nora Linscheid, Alberto Santos, Pi Camilla Poulsen, Robert W Mills, Kirstine Calloe, Ulrike Leurs, Johan Z Ye, Christian Stolte, Morten B Thomsen, Bo H Bentzen, Pia R Lundegaard, Morten S Olesen, Lars J Jensen, Jesper V Olsen, Alicia Lundby
Publikováno v: PLoS Biology, Vol 19, Iss 4, p e3001144 (2021)
Delineating human cardiac pathologies and their basic molecular mechanisms relies on research conducted in model organisms. Yet translating findings from preclinical models to humans present a significant challenge, in part due to differences in card
Externí odkaz: https://doaj.org/article/803278d7d2314c97a5198af5d5449f9c
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8
Intramural Purkinje fibers facilitate rapid ventricular activation in the equine heart
Autor: Vibeke S. Elbrønd, Morten B. Thomsen, Jonas L. Isaksen, Ester D. Lunde, Stefano Vincenti, Tobias Wang, Jørgen Tranum‐Jensen, Kirstine Calloe
Publikováno v: Elbrønd, V S, Thomsen, M B, Isaksen, J L, Lunde, E D, Vincenti, S, Wang, T, Tranum-Jensen, J & Calloe, K 2023, ' Intramural Purkinje fibers facilitate rapid ventricular activation in the equine heart ', Acta Physiologica, vol. 237, no. 3, e13925 . https://doi.org/10.1111/apha.13925
UNLABELLED: The Purkinje fibers convey the electrical impulses at much higher speed than the working myocardial cells. Thus, the distribution of the Purkinje network is of paramount importance for the timing and coordination of ventricular activation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a545f2a49beb9028eb8435105c6a183
https://curis.ku.dk/portal/da/publications/intramural-purkinje-fibers-facilitate-rapid-ventricular-activation-in-the-equine-heart(0610ed6d-dc8d-45cd-8436-454e366800d9).html
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10
Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly
Autor: Morten B. Thomsen, Thomas A. Jepps, Geoffrey W. Abbott, Rían W. Manville, Jennifer van der Horst, Katie Hayes
Publikováno v: Van Der Horst, J, Manville, R W, Hayes, K, Thomsen, M B, Abbott, G W & Jepps, T A 2020, ' Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly ', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 40, no. 5, pp. 1207-1219 . https://doi.org/10.1161/ATVBAHA.120.313997
Arterioscler Thromb Vasc Biol
Objective: Intravenous acetaminophen/paracetamol (APAP) is well documented to cause hypotension. Since the patients receiving intravenous APAP are usually critically ill, any severe hemodynamic changes, as with those associated with APAP, can be life
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc24b43e295bdb5d085e64fcbd158a8d
https://doi.org/10.1161/atvbaha.120.313997
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