Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Morten B, Strøm"'
Autor:
Dominik Ausbacher, Lindsey A. Miller, Darla M. Goeres, Philip S. Stewart, Morten B. Strøm, Adyary Fallarero
Publikováno v:
Biofilm, Vol 6, Iss , Pp 100151- (2023)
Bacterial biofilms account for up to 80% of all infections and complicate successful therapies due to their intrinsic tolerance to antibiotics. Biofilms also cause serious problems in the industrial sectors, for instance due to the deterioration of m
Externí odkaz:
https://doaj.org/article/805c706c6f324f43ac6dba6edcf2b694
Autor:
Susannah von Hofsten, Marianne Hagensen Paulsen, Synnøve Norvoll Magnussen, Dominik Ausbacher, Mathias Kranz, Annette Bayer, Morten B. Strøm, Gerd Berge
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Bioprospecting contributes to the discovery of new molecules with anticancer properties. Compounds with cytolytic activity and the ability to induce immunogenic cell death can be administered as intratumoral injections with the aim to activa
Externí odkaz:
https://doaj.org/article/31e43ab87eee4af99377697000c2c9e8
Autor:
Susannah von Hofsten, Manuel K. Langer, Katja Korelin, Synnøve Magnussen, Dominik Ausbacher, Trude Anderssen, Tuula Salo, Morten B. Strøm, Annette Bayer, Ahmed Al-Samadi, Gerd Berge
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The incidence of head and neck squamous cell carcinoma (HNSCC) is increasing and the conventional treatments for this form of cancer can be tough. Despite the success of existing immunotherapies in some HNSCC patients, many do not respond to this typ
Externí odkaz:
https://doaj.org/article/4ae4b24904eb41559c8b9a2b94c79d64
Autor:
Lisa Myrseth Hemmingsen, Barbara Giordani, Marianne H. Paulsen, Željka Vanić, Gøril Eide Flaten, Beatrice Vitali, Purusotam Basnet, Annette Bayer, Morten B. Strøm, Nataša Škalko-Basnet
The eradication of bacteria embedded in biofilms is among the most challenging obstacles in the management of chronic wounds. These biofilms are found in most chronic wounds ; moreover, the biofilm-embedded bacteria are considerably less susceptible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c91eaa5439a66bf03835bca6a5c8c2
https://hdl.handle.net/10037/27887
https://hdl.handle.net/10037/27887
Autor:
Hymonti Dey, Danijela Simonovic, Ingrid Norberg-Schulz Hagen, Terje Vasskog, Elizabeth G. Aarag Fredheim, Hans-Matti Blencke, Trude Anderssen, Morten B. Strøm, Tor Haug
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 22; Pages: 13844
We have synthesised short analogues of the marine antimicrobial peptide Turgencin A from the colonial Arctic ascidian Synoicum turgens. In this study, we focused on a central, cationic 12-residue Cys-Cys loop region within the sequence. Modified (try
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e0f86fb7635e0ad6aaccbb6c576b18
https://pubmed.ncbi.nlm.nih.gov/36430320
https://pubmed.ncbi.nlm.nih.gov/36430320
Autor:
Manuel K. Langer, Ataur Rahman, Hymonti Dey, Trude Anderssen, Hans-Matti Blencke, Tor Haug, Klara Stensvåg, Morten B. Strøm, Annette Bayer
Publikováno v:
European Journal of Medicinal Chemistry. 249:115147
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09ded1530601480f4bb4691f7288543
https://doi.org/10.1016/j.ejmech.2023.115147
https://doi.org/10.1016/j.ejmech.2023.115147
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157306 (2016)
We demonstrate in the current work that small cationic antimicrobial β2,2-amino acid derivatives (Mw < 500 Da) are highly potent against Chlamydia pneumoniae at clinical relevant concentrations (< 5 μM, i.e. < 3.4 μg/mL). C. pneumoniae is an atypi
Externí odkaz:
https://doaj.org/article/9a2b37b8f9ec4c2a966fd429dfd13972
Autor:
Manuel K. Langer, Ataur Rahman, Hymonti Dey, Trude Anderssen, Francesco Zilioli, Tor Haug, Hans-Matti Blencke, Klara Stensvåg, Morten B. Strøm, Annette Bayer
Publikováno v:
European Journal of Medicinal Chemistry. 241:114632
An amphipathic barbiturate mimic of the marine eusynstyelamides is reported as a promising class of antimicrobial agents. We hereby report a detailed analysis of the structure-activity relationship for cationic amphipathic N,N′ -dialkylated-5,5-dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9160fcfce483db116bf350bd267febfa
https://doi.org/10.1016/j.ejmech.2022.114632
https://doi.org/10.1016/j.ejmech.2022.114632
Autor:
Dominik Ausbacher, Trude Anderssen, Glenn R. Morello, Hans-Matti Blencke, Manuel K Langer, Eric Juskewitz, Morten B. Strøm, Tor Haug, Laura Liikanen, Annette Bayer, Johan Isaksson, Marianne Hagensen Paulsen, Magnus Engqvist
Publikováno v:
Journal of medicinal chemistry. 64(15)
We report a series of synthetic cationic amphipathic barbiturates inspired by the pharmacophore model of small antimicrobial peptides (AMPs) and the marine antimicrobials eusynstyelamides. These N,N'-dialkylated-5,5-disubstituted barbiturates consist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669c12a4ab3020d9d14a0f4200f8913f
https://pubmed.ncbi.nlm.nih.gov/34314189
https://pubmed.ncbi.nlm.nih.gov/34314189
Autor:
Ekaterina Mishchenko, Elizaveta M. Igumnova, Elizabeth G. Aarag Fredheim, Klara Stensvåg, Johanna U. Ericson Sollid, Hans-Matti Blencke, Tor Haug, Silje Lauksund, Morten B. Strøm
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:4930-4941
There is an urgent need for novel antimicrobial agents to address the threat of bacterial resistance to modern society. We have used a structural motif found in antimicrobial marine hit compounds as a basis for synthesizing a library of antimicrobial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2543efcdc9a356b61a5d0ddcfd4e292e
https://doi.org/10.1016/j.bmc.2018.08.032
https://doi.org/10.1016/j.bmc.2018.08.032