Zobrazeno 1 - 10
of 971
pro vyhledávání: '"Morten A. Karsdal"'
Autor:
Helene Wallem Breisnes, Diana Julie Leeming, Morten Asser Karsdal, Hannah Burke, Anna Freeman, Tom Wilkinson, Aishath Fazleen, Jannie Marie Bülow Sand
Publikováno v:
BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Coronavirus disease 2019 (COVID-19) is a viral pneumonia that can result in serious respiratory illness. It is associated with extensive systemic inflammation, changes to the lung extracellular matrix, and long-term lung impairmen
Externí odkaz:
https://doaj.org/article/636ae4558c0045018e33158315e85a88
Autor:
Khaled Elhady Mohamed, Anna Thorsø Larsen, Simone Melander, Frederik Andersen, Ellen Barendorff Kerrn, Morten Asser Karsdal, Kim Henriksen
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-11 (2024)
Abstract Background Despite the extensive research to provide a disease-modifying osteoarthritis drug (DMOAD), there is still no approved DMOAD. Dual amylin and calcitonin receptor agonists (DACRA) can provide metabolic benefits along with antinocice
Externí odkaz:
https://doaj.org/article/3573830610a348da9a886335d22b38fc
Autor:
Sofie Falkenløve Madsen, Dovile Sinkeviciute, Christian S. Thudium, Morten A. Karsdal, Anne-Christine Bay-Jensen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Type III collagen gene expression is upregulated in the synovium of patients with rheumatoid arthritis (RA) presenting the fibroid phenotype. The soluble type III collagen formation biomarker, PRO-C3, is known to measure fibrogenesis in fibr
Externí odkaz:
https://doaj.org/article/9dfeba6e89044064af703a8e285e3add
Autor:
Asger Reinstrup Bihlet, Torben Balchen, Kosalaram Goteti, Jesper Sonne, Christoph Ladel, Morten Asser Karsdal, Victor Ona, Flavie Moreau, Roseann Waterhouse, Anne‐Christine Bay‐Jensen, Hans Guehring
Publikováno v:
ACR Open Rheumatology, Vol 6, Iss 4, Pp 205-213 (2024)
Objective To assess the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple injections of M6495, a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS‐5) nanobody, in healthy volunteers and patients wi
Externí odkaz:
https://doaj.org/article/59a53152c87d4341ac5e68cc12a2ad20
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 6, Iss 4, Pp 100527- (2024)
Objective: The development of disease-modifying drugs is limited by OA's heterogeneity and the challenge of defining clinical endpoints. Serological biomarkers are considered potential surrogate endpoints, but their contribution from single joints to
Externí odkaz:
https://doaj.org/article/ea2442c807d1402bb80cfccc878e23d5
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-10 (2024)
Abstract Objectives Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation in multiple articular joints, causing pain, joint damage, and loss of joint function. Despite the successful development of disease-modifying
Externí odkaz:
https://doaj.org/article/d632f2e3b3814913af442492e9664f63
Autor:
Marta S. Alexdottir, Martin Pehrsson, Viktor Domislovic, Line E. Godskesen, Aleksander Krag, Jens Kjeldsen, Marko Brinar, Ana Barisic, Anne-Christine Bay-Jensen, Morten A. Karsdal, Zeljko Krznaric, Joachim H. Mortensen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Neutrophils play a significant role in sustaining chronic inflammation in Inflammatory Bowel Disease. The intestinal basement membrane acts as a barrier for immunological homeostasis, where the α3 and α4 chains of type IV collagen are expr
Externí odkaz:
https://doaj.org/article/36ce61ebf75c4f13b829c1c0aa30a870
Autor:
Cecilie Liv Bager, Joseph P. M. Blair, Man-Hung Eric Tang, Joachim Høg Mortensen, Anne-Christine Bay-Jensen, Peder Frederiksen, Diana Leeming, Claus Christiansen, Morten Asser Karsdal
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Citrullinated vimentin has been linked to several chronic and autoimmune diseases, but how citrullinated vimentin is associated with disease prevalence and genetic variants in a clinical setting remains unknown. The aim of this study was to
Externí odkaz:
https://doaj.org/article/c4f6f264d46947fc8cdd368070733f5f
Autor:
Oliver Distler, Britta Maurer, Suzana Jordan, Carina Mihai, Rucsandra Dobrota, Mike Becker, Morten Asser Karsdal, Nicoletta Del Papa, Anne Sofie Siebuhr, Anne-C Bay-Jensen, Pernille Juhl
Publikováno v:
RMD Open, Vol 10, Iss 2 (2024)
Objective Clinical observation suggests that vascular activation and autoimmunity precede remodelling of the extracellular matrix (ECM) in systemic sclerosis (SSc). We challenge this paradigm by hypothesising that ECM biomarkers are already disturbed
Externí odkaz:
https://doaj.org/article/634f22d560e5462fbaa97c1abf5bfba8
Autor:
Firas F. Alkaff, MD, Daan Kremer, MD, Olivier Thaunat, MD, PhD, Stefan P. Berger, MD, PhD, Jacob van den Born, PhD, Federica Genovese, PhD, Morten A. Karsdal, PhD, Stephan J. L. Bakker, MD, PhD, Daniel G. K. Rasmussen, PhD, Martin Tepel, MD
Publikováno v:
Transplantation Direct, Vol 10, Iss 3, p e1591 (2024)
Background. Kidney fibrosis is a suggested cause of kidney failure and premature mortality. Because collagen type VI is closely linked to kidney fibrosis, we aimed to evaluate whether urinary endotrophin, a collagen type VI fragment, is associated wi
Externí odkaz:
https://doaj.org/article/c8aa90a7f031435095eeb219f8b3ce33