Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Morten, Schlein"'
Autor:
Kirsten Raun, Eva Johansson, Morten Schlein, Ulrich Sensfuss, Christian Poulsen, Simone Fulle, Kirsten Dahl, Lauge Schäffer, Ann Maria Kruse Hansen, Trine R. Clausen, Jakob Lerche Hansen, Charlotta Dornonville de la Cour, Rikke Bjerring Skyggebjerg, Thomas Kruse, Claus Bekker Jeppesen
Publikováno v:
Journal of Medicinal Chemistry. 64:11183-11194
A hallmark of the pancreatic hormone amylin is its high propensity toward the formation of amyloid fibrils, which makes it a challenging drug design effort. The amylin analogue pramlintide is commercially available for diabetes treatment as an adjunc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eaa793c2245d270ddc8b3148f54058f
https://doi.org/10.1021/acs.jmedchem.1c00565
https://doi.org/10.1021/acs.jmedchem.1c00565
Autor:
Tine N Vinther, Mathias Norrman, Holger M Strauss, Kasper Huus, Morten Schlein, Thomas Å Pedersen, Thomas Kjeldsen, Knud J Jensen, František Hubálek
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30882 (2012)
An ingenious system evolved to facilitate insulin binding to the insulin receptor as a monomer and at the same time ensure sufficient stability of insulin during storage. Insulin dimer is the cornerstone of this system. Insulin dimer is relatively we
Externí odkaz:
https://doaj.org/article/56be5fcb4f9d42f782c421c1d91bc207
Autor:
Morten Schlein
Publikováno v:
The AAPS Journal. 19:397-408
The insulin molecule was discovered in 1921. Shortly thereafter, its propensity towards amyloid fibril formation, fibrillation, was observed and described in the literature as a "precipitate." In the past decades, the increased incidence of type 2 di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c812f804034abbe6e49e045d558643fa
https://doi.org/10.1208/s12248-016-0028-6
https://doi.org/10.1208/s12248-016-0028-6
Autor:
Knud J. Jensen, Morten Schlein, Anders S. Sørensen, Ingrid Pettersson, Kasper Huus, Tine N. Vinther, Thomas Kjeldsen, Frantisek Hubalek, Dorte Bjerre Steensgaard
Publikováno v:
Protein Science. 24:779-788
The structure of insulin, a glucose homeostasis-controlling hormone, is highly conserved in all vertebrates and stabilized by three disulfide bonds. Recently, we designed a novel insulin analogue containing a fourth disulfide bond located between pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f46b57fab82ced83f61f3ab2c76a5c0
https://doi.org/10.1002/pro.2649
https://doi.org/10.1002/pro.2649
Autor:
Knud J. Jensen, Ulla Ribel, Morten Schlein, Thomas Åskov Pedersen, Ingrid Pettersson, Svend Ludvigsen, Kasper Huus, Mathias Norrman, Tine N. Vinther, Thomas Kjeldsen, Frantisek Hubalek, Dorte Bjerre Steensgaard
Publikováno v:
Protein Science. 22:296-305
Insulin is a key hormone controlling glucose homeostasis. All known vertebrate insulin analogs have a classical structure with three 100% conserved disulfide bonds that are essential for structural stability and thus the function of insulin. It might
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7f79cf205328b66ca4506dd399f8840
https://doi.org/10.1002/pro.2211
https://doi.org/10.1002/pro.2211
Autor:
Svend Ludvigsen, Morten Schlein, Gillian M. Danielsen, Helle Birk Olsen, Niels C. Kaarsholm, Asser Sloth Andersen
Publikováno v:
Biochemistry. 40:13520-13528
Small molecules with insulin mimetic effects and oral availability are of interest for potential substitution of insulin injections in the treatment of diabetes. We have searched databases for compounds capable of mimicking one epitope of the insulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ead145a94d65249d7c7e8f82655462
https://doi.org/10.1021/bi015672w
https://doi.org/10.1021/bi015672w
Autor:
Karen Skriver, Morten Schlein, Dora Raventos, John Mundy, Klaus Karnahl, John C. Rogers, Sally W. Rogers
Publikováno v:
Journal of Biological Chemistry. 273:23313-23320
A barley gene encoding a novel DNA-binding protein (HRT) was identified by southwestern screening with baits containing a gibberellin phytohormone response element from an alpha-amylase promoter. The HRT gene contains two introns, the larger of which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5317dabff48dd4d4d784f4556b0a2273
https://doi.org/10.1074/jbc.273.36.23313
https://doi.org/10.1074/jbc.273.36.23313
Autor:
Tine N, Vinther, Mathias, Norrman, Ulla, Ribel, Kasper, Huus, Morten, Schlein, Dorte B, Steensgaard, Thomas Å, Pedersen, Ingrid, Pettersson, Svend, Ludvigsen, Thomas, Kjeldsen, Knud J, Jensen, František, Hubálek
Publikováno v:
Protein science : a publication of the Protein Society. 22(3)
Insulin is a key hormone controlling glucose homeostasis. All known vertebrate insulin analogs have a classical structure with three 100% conserved disulfide bonds that are essential for structural stability and thus the function of insulin. It might
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd6bec06fb7a4f24d6310e0381a742c6
https://pubmed.ncbi.nlm.nih.gov/23281053
https://pubmed.ncbi.nlm.nih.gov/23281053
Autor:
Gerd Schluckebier, Helle Naver, Dorte Bjerre Steensgaard, Karina Sinding Thorsøe, Jakob Brandt, Morten Schlein
Publikováno v:
Biochemistry. 49(29)
Through binding to and signaling via the insulin receptor (IR), insulin is involved in multiple effects on growth and metabolism. The current model for the insulin-IR binding process is one of a biphasic reaction. It is thought that the insulin pepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b314772f9c1ce20c6b9c5d709d7312
https://pubmed.ncbi.nlm.nih.gov/20568733
https://pubmed.ncbi.nlm.nih.gov/20568733
Publikováno v:
Spectroscopy.
We have applied spectroscopic techniques to study two kinds of ligand binding to the insulin receptor. First, a fluorescently labelled insulin analogue is used to characterize the mechanism of reversible 1 :1 complex formation with a fragment of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13dcaa480bbe3df675e2fdf3e602441