Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Morten, Lundh"'
Autor:
Anniek F. Lubberding, Jinyi Zhang, Morten Lundh, Thomas Svava Nielsen, Mathilde S. Søndergaard, Maria Villadsen, Emil Z. Skovhøj, Geke A. Boer, Jakob B. Hansen, Morten B. Thomsen, Jonas T. Treebak, Jens J. Holst, Jørgen K. Kanters, Thomas Mandrup-Poulsen, Thomas Jespersen, Brice Emanuelli, Signe S. Torekov
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Loss-of-function (LoF) mutations in KCNQ1, encoding the voltage-gated K+ channel Kv7.1, lead to long QT syndrome 1 (LQT1). LQT1 patients also present with post-prandial hyperinsulinemia and hypoglycaemia. In contrast, KCNQ1 polymorphisms are
Externí odkaz:
https://doaj.org/article/bdb0c435470a478696e2cc00273a4925
Autor:
Morten Lundh, Ali Altıntaş, Marco Tozzi, Odile Fabre, Tao Ma, Farnaz Shamsi, Zachary Gerhart-Hines, Romain Barrès, Yu-Hua Tseng, Brice Emanuelli
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The profound energy-expending nature of brown adipose tissue (BAT) thermogenesis makes it an attractive target tissue to combat obesity-associated metabolic disorders. While cold exposure is the strongest inducer of BAT activity, the tempora
Externí odkaz:
https://doaj.org/article/d7c56c917a264bc39cc895ee89f8c7c9
Autor:
Farnaz Shamsi, Ruidan Xue, Tian Lian Huang, Morten Lundh, Yang Liu, Luiz O. Leiria, Matthew D. Lynes, Elena Kempf, Chih-Hao Wang, Satoru Sugimoto, Pasquale Nigro, Kathrin Landgraf, Tim Schulz, Yiming Li, Brice Emanuelli, Srinivas Kothakota, Lewis T. Williams, Niels Jessen, Steen Bønløkke Pedersen, Yvonne Böttcher, Matthias Blüher, Antje Körner, Laurie J. Goodyear, Moosa Mohammadi, C. Ronald Kahn, Yu-Hua Tseng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue. Here the authors show that FGF6 and FGF9 induce UCP1 expression in adipocytes and preadipocytes, via modulation of a transcriptional network that is disso
Externí odkaz:
https://doaj.org/article/de377e337a5a402280aaea762fc97cbe
Autor:
Jacob Ardenkjær-Larsen, Kaja Rupar, Goda Sinkevičiūtė, Patricia S. S. Petersen, Julia Villarroel, Morten Lundh, Romain Barrès, Atefeh Rabiee, Brice Emanuelli
Publikováno v:
Adipocyte, Vol 9, Iss 1, Pp 142-152 (2020)
Insulin action initiates a series of phosphorylation events regulating cellular differentiation, growth and metabolism. We have previously discovered, in a mass spectrometry-based phosphoproteomic study, that insulin/IGF-1 signalling induces phosphor
Externí odkaz:
https://doaj.org/article/f3f9b1d3b2ba44c89c6383fade3eef18
Autor:
Atefeh Rabiee, Kaja Plucińska, Marie Sophie Isidor, Erin Louise Brown, Marco Tozzi, Simone Sidoli, Patricia Stephanie S. Petersen, Marina Agueda-Oyarzabal, Silje Bøen Torsetnes, Galal Nazih Chehabi, Morten Lundh, Ali Altıntaş, Romain Barrès, Ole Nørregaard Jensen, Zachary Gerhart-Hines, Brice Emanuelli
Publikováno v:
Molecular Metabolism, Vol 44, Iss , Pp 101137- (2021)
Objective: Increasing adaptive thermogenesis by stimulating browning in white adipose tissue is a promising method of improving metabolic health. However, the molecular mechanisms underlying this transition remain elusive. Our study examined the mole
Externí odkaz:
https://doaj.org/article/3ec0e86a99cb48918152952591886535
Publikováno v:
Molecular Metabolism, Vol 6, Iss 10, Pp 1313-1320 (2017)
Objective: Functional investigation of novel gene/protein targets associated with adipocyte differentiation or function heavily relies on efficient and accessible tools to manipulate gene expression in adipocytes in vitro. Recent advances in gene-edi
Externí odkaz:
https://doaj.org/article/b599e65ebc6b4a04bddc934938f6e725
Autor:
Kaja Plucinska, Brice Emanuelli, Marie S. Isidor, Jonas T. Treebak, Patricia S.S. Petersen, Marco Tozzi, Thomas Nielsen, Morten Lundh, Erin L. Brown, Marina Agueda-Oyarzabal, Lewin Small
Publikováno v:
Tozzi, M, Brown, E L, Petersen, P SS, Lundh, M, Isidor, M S, Plucińska, K, Nielsen, T S, Agueda-Oyarzabal, M, Small, L, Treebak, J T & Emanuelli, B 2022, ' Dynamic interplay between Afadin S1795 phosphorylation and diet regulates glucose homeostasis in obese mice ', The Journal of Physiology, vol. 600, no. 4, pp. 885-902 . https://doi.org/10.1113/JP281657
Key points Afadin is a ubiquitously expressed scaffold protein with a recently discovered role in insulin signaling and glucose metabolism. Insulin-stimulated phosphorylation of Afadin at S1795 occurs in insulin-responsive tissues such as adipose tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::975e957658243a480821a0766ea1b944
https://doi.org/10.1113/jp281657
https://doi.org/10.1113/jp281657
Autor:
Lisbeth Nielsen Fink, Nina Buch-Månson, Knud J. Jensen, Narendra Kumar Mishra, Niels Vrang, Søren L. Pedersen, Karin Mannerstedt, Keld Fosgerau, Thomas Brimert, Philip J. Pedersen, Priska Le-Huu, Charlotte Madsen, Ebbe Engholm, Björn Borgström, Morten Lundh
Publikováno v:
Chemistry – A European Journal. 27:3166-3176
A glucose responsive insulin (GRI) that responds to changes in blood glucose concentrations has remained an elusive goal. Here we describe the development of glucose cleavable linkers based on hydrazone and thiazolidine structures. We developed linke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1652c966395346e739b27aaa9084a02
https://doi.org/10.1002/chem.202004878
https://doi.org/10.1002/chem.202004878
Autor:
Søren Nielsen, Morten Lundh, Raziel Rojas-Rodriguez, Silvia Corvera, Zinger Yang, Bente Klarlund Pedersen, Anand Desai, Erin L. Brown, Camilla Scheele, Khanh-Van Tran, Tiffany DeSouza, Therese Juhlin Larsen, Qin Yang, Timothy P. Fitzgibbons, Kimberly T. Malka, Anthony M. Mozzicato, Naja Z. Jespersen, Amir Feizi, Hanni Willenbrock, Cecilie Nandrup-Bus, Mai Charlotte Krogh Severinsen, Atul S. Deshmukh, Brice Emanuelli, So Yun Min
Publikováno v:
Nature metabolism
Human thermogenic adipose tissue mitigates metabolic disease, thus raising much interest in understanding its development and function. Here, we show that human thermogenic adipocytes specifically express a primate-specific long noncoding RNA (lncRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850cdf716ed5fab6437b2076fb272475
https://doi.org/10.1038/s42255-020-0205-x
https://doi.org/10.1038/s42255-020-0205-x
Autor:
Yiming Li, Matthew D. Lynes, Lewis T. Williams, Tim J. Schulz, Steen B. Pedersen, Tian Lian Huang, Niels Jessen, Farnaz Shamsi, Laurie J. Goodyear, Morten Lundh, Matthias Blüher, Srinivas Kothakota, Moosa Mohammadi, Yu-Hua Tseng, Ruidan Xue, Chih-Hao Wang, Pasquale Nigro, Satoru Sugimoto, Brice Emanuelli, Antje Körner, Yang Liu, Luiz O. Leiria, Elena Kempf, Kathrin Landgraf, C. Ronald Kahn, Yvonne Böttcher
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Shamsi, F, Xue, R, Huang, T L, Lundh, M, Liu, Y, Leiria, L O, Lynes, M D, Kempf, E, Wang, C-H, Sugimoto, S, Nigro, P, Landgraf, K, Schulz, T, Li, Y, Emanuelli, B, Kothakota, S, Williams, L T, Jessen, N, Pedersen, S B, Böttcher, Y, Blüher, M, Körner, A, Goodyear, L J, Mohammadi, M, Kahn, C R & Tseng, Y-H 2020, ' FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis ', Nature Communications, vol. 11, no. 1, 1421 . https://doi.org/10.1038/s41467-020-15055-9
Shamsi, F, Xue, R, Huang, T L, Lundh, M, Liu, Y, Leiria, L O, Lynes, M D, Kempf, E, Wang, C H, Sugimoto, S, Nigro, P, Landgraf, K, Schulz, T, Li, Y, Emanuelli, B, Kothakota, S, Williams, L T, Jessen, N, Pedersen, S B, Böttcher, Y, Blüher, M, Körner, A, Goodyear, L J, Mohammadi, M, Kahn, C R & Tseng, Y H 2020, ' FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis ', Nature Communications, vol. 11, no. 1, 1421 . https://doi.org/10.1038/s41467-020-15055-9
Nature Communications
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Shamsi, F, Xue, R, Huang, T L, Lundh, M, Liu, Y, Leiria, L O, Lynes, M D, Kempf, E, Wang, C-H, Sugimoto, S, Nigro, P, Landgraf, K, Schulz, T, Li, Y, Emanuelli, B, Kothakota, S, Williams, L T, Jessen, N, Pedersen, S B, Böttcher, Y, Blüher, M, Körner, A, Goodyear, L J, Mohammadi, M, Kahn, C R & Tseng, Y-H 2020, ' FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis ', Nature Communications, vol. 11, no. 1, 1421 . https://doi.org/10.1038/s41467-020-15055-9
Shamsi, F, Xue, R, Huang, T L, Lundh, M, Liu, Y, Leiria, L O, Lynes, M D, Kempf, E, Wang, C H, Sugimoto, S, Nigro, P, Landgraf, K, Schulz, T, Li, Y, Emanuelli, B, Kothakota, S, Williams, L T, Jessen, N, Pedersen, S B, Böttcher, Y, Blüher, M, Körner, A, Goodyear, L J, Mohammadi, M, Kahn, C R & Tseng, Y H 2020, ' FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis ', Nature Communications, vol. 11, no. 1, 1421 . https://doi.org/10.1038/s41467-020-15055-9
Nature Communications
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue (BAT). Using high-throughput library screening of secreted peptides, we identify two fibroblast growth factors (FGF), FGF6 and FGF9, as potent inducers of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb9c21dc7ca2f3f0a151ee36d85f6ff
https://doaj.org/article/de377e337a5a402280aaea762fc97cbe
https://doaj.org/article/de377e337a5a402280aaea762fc97cbe