Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions.

Autor: Lam I; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Ndayisaba A; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Division of Neurobiology, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Lewis AJ; École Polytechnique Fédérale de Lausanne and University of Lausanne, Lausanne, Switzerland., Fu Y; The University of Sydney Brain and Mind Centre and Faculty of Medicine and Health School of Medical Science, Sydney, NSW, Australia., Sagredo GT; The University of Sydney Brain and Mind Centre and Faculty of Medicine and Health School of Medical Science, Sydney, NSW, Australia., Kuzkina A; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Zaccagnini L; Dementia Research Institute, University College London, London, UK., Celikag M; Dementia Research Institute, University College London, London, UK., Sandoe J; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Sanz RL; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Vahdatshoar A; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Martin TD; Harvard Medical School, Boston, MA, USA; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Morshed N; Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA; Boston Children's Hospital, Boston, MA, USA; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ichihashi T; Nikon Corporation, Tokyo, Japan., Tripathi A; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Ramalingam N; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Oettgen-Suazo C; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Bartels T; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Boussouf M; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Schäbinger M; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Hallacli E; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Jiang X; Yumanity Therapeutics, Cambridge, MA, USA., Verma A; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Tea C; University of California, San Diego, San Diego, CA, USA., Wang Z; University of California, San Diego, San Diego, CA, USA., Hakozaki H; University of California, San Diego, San Diego, CA, USA., Yu X; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Hyles K; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Park C; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA., Wang X; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Theunissen TW; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Wang H; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Jaenisch R; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Lindquist S; Whitehead Institute for Biomedical Research, Cambridge, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Stevens B; Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA; Boston Children's Hospital, Boston, MA, USA; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Stefanova N; Division of Neurobiology, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Wenning G; Division of Neurobiology, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., van de Berg WDJ; Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, the Netherlands., Luk KC; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Sanchez-Pernaute R; BioBizkaia Health Research Institute, Barakaldo, Spain; Ikerbasque, Basque Foundation for Science, Bilbao, Spain., Gómez-Esteban JC; BioBizkaia Health Research Institute, Barakaldo, Spain., Felsky D; Centre for Addiction and Mental Health, Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada., Kiyota Y; Nikon Corporation, Tokyo, Japan., Sahni N; The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Baylor College of Medicine, Houston, TX, USA., Yi SS; The University of Texas at Austin, Austin, TX, USA., Chung CY; Yumanity Therapeutics, Cambridge, MA, USA., Stahlberg H; École Polytechnique Fédérale de Lausanne and University of Lausanne, Lausanne, Switzerland., Ferrer I; The University of Barcelona, Institut d'Investigacio Biomedica de Bellvitge IDIBELL, Hospitalet de Llobregat, Barcelona, Spain., Schöneberg J; University of California, San Diego, San Diego, CA, USA., Elledge SJ; Harvard Medical School, Boston, MA, USA; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Dettmer U; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Halliday GM; The University of Sydney Brain and Mind Centre and Faculty of Medicine and Health School of Medical Science, Sydney, NSW, Australia; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA., Bartels T; Dementia Research Institute, University College London, London, UK., Khurana V; Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA; Division of Movement Disorders, American Parkinson Disease Association (APDA) Center for Advanced Research and MSA Center of Excellence, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; The Broad Institute of MIT and Harvard, Cambridge, MA, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, USA; Harvard Stem Cell Institute, Cambridge, MA, USA. Electronic address: khuranalab_admin@bwh.harvard.edu.

Publikováno v: Neuron [Neuron] 2024 Sep 04; Vol. 112 (17), pp. 2886-2909.e16. Date of Electronic Publication: 2024 Jul 29.

Biological and clinical significance of the glypican-3 gene in human lung adenocarcinoma: An in silico analysis.

Autor: Imon RR; Laboratory of Computational Biology, Biological Solution Centre (BioSol Centre), Jashore, Bangladesh.; Department of Genetic Engineering and Biotechnology, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore, Bangladesh., Aktar S; Laboratory of Computational Biology, Biological Solution Centre (BioSol Centre), Jashore, Bangladesh.; Department of Microbiology, Faculty of Biological Science, University of Dhaka, Dhaka, Bangladesh., Morshed N; Laboratory of Computational Biology, Biological Solution Centre (BioSol Centre), Jashore, Bangladesh.; Department of Pharmacy, Faculty of Biological Science, University of Dhaka, Dhaka, Bangladesh., Nur SM; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia., Mahtarin R; Laboratory of Computational Biology, Biological Solution Centre (BioSol Centre), Jashore, Bangladesh.; Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, Bangladesh., Rahman FA; Laboratory of Computational Biology, Biological Solution Centre (BioSol Centre), Jashore, Bangladesh.; Department of Genetic Engineering and Biotechnology, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore, Bangladesh., Talukder MEK; Laboratory of Computational Biology, Biological Solution Centre (BioSol Centre), Jashore, Bangladesh.; Department of Genetic Engineering and Biotechnology, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore, Bangladesh., Alam R; Laboratory of Computational Biology, Biological Solution Centre (BioSol Centre), Jashore, Bangladesh.; Department of Genetic Engineering and Biotechnology, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore, Bangladesh., Karpiński TM; Chair and Department of Medical Microbiology, Poznań University of Medical Sciences, Wieniawskiego, Poland., Ahammad F; Laboratory of Computational Biology, Biological Solution Centre (BioSol Centre), Jashore, Bangladesh.; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia., Zamzami MA; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.; Centre of Artificial Intelligence for Precision Medicines, King Abdulaziz University, Jeddah, Saudi Arabia., Tan SC; UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Publikováno v: Medicine [Medicine (Baltimore)] 2023 Nov 10; Vol. 102 (45), pp. e35347.

Targeting SARS-CoV-2 non-structural protein 13 via helicase-inhibitor-repurposing and non-structural protein 16 through pharmacophore-based screening.

Autor: Samdani MN; Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh., Morshed N; Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh., Reza R; Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh., Asaduzzaman M; Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh. asaduzzaman@du.ac.bd., Islam ABMMK; Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka, 1000, Bangladesh. khademul@du.ac.bd.

Publikováno v: Molecular diversity [Mol Divers] 2023 Jun; Vol. 27 (3), pp. 1067-1085. Date of Electronic Publication: 2022 Jun 12.

Polymeric Nanoparticles for Targeted Delivery in Cancer Treatment: An Overview

Autor: Morshed, N

Advances in polymeric nanoparticles are rapidly progressing and offers new opportunities for targeted treatment of cancer. Nanoparticulate drug-delivery systems are capable of preferentially targeting large doses of chemotherapeutic agents or therape

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::165cd250cd54ea850f8d66fe8c3e3de4
https://hdl.handle.net/10453/136970

Non-viral gene delivery utilizing RALA modulates sFlt-1 secretion, important for preeclampsia.

Autor: McNally R; The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, BT9 7BL, Northern Ireland., Alqudah A; The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, BT9 7BL, Northern Ireland.; Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, The Hashemite University, Zarqa, 13133, Jordan., McErlean EM; School of Pharmacy, Queen's University Belfast, Northern Ireland, BT9 7BL, UK., Rennie C; School of Life Sciences, Faculty of Science, University of Technology Sydney, NSW, 2007, Australia., Morshed N; School of Mathematical & Physical Sciences, Faculty of Science, University of Technology Sydney, NSW, 2007, Australia., Short A; School of Pharmacy, Queen's University Belfast, Northern Ireland, BT9 7BL, UK., McGrath K; School of Life Sciences, Faculty of Science, University of Technology Sydney, NSW, 2007, Australia., Shimoni O; School of Mathematical & Physical Sciences, Faculty of Science, University of Technology Sydney, NSW, 2007, Australia., Robson T; School of Pharmacy & Biomolecular Sciences, Irish Centre for Vascular Biology, RCSI University of Medicine & Health Sciences, Dublin, 02, YN77, Republic of Ireland., McCarthy HO; School of Pharmacy, Queen's University Belfast, Northern Ireland, BT9 7BL, UK., McClements L; The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, BT9 7BL, Northern Ireland.; School of Life Sciences, Faculty of Science, University of Technology Sydney, NSW, 2007, Australia.

Publikováno v: Nanomedicine (London, England) [Nanomedicine (Lond)] 2021 Sep; Vol. 16 (22), pp. 1999-2012. Date of Electronic Publication: 2021 Aug 26.