Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Morse Faria"'
Autor:
Morse Faria, Marlking Peay, Brandon Lam, Eric Ma, Moucun Yuan, Michael Waldron, William R. Mylott, Meina Liang, Anton I. Rosenbaum
Publikováno v:
Antibodies, Vol 8, Iss 1, p 11 (2019)
Bioanalysis of complex biotherapeutics, such as antibody-drug conjugates (ADCs), is challenging and requires multiple assays to describe their pharmacokinetic (PK) profiles. To enable exposure-safety and exposure-efficacy analyses, as well as to unde
Externí odkaz:
https://doaj.org/article/186e79de837f432e8bf399a706527bdc
Autor:
Tom Mariannino, William Mylott, Pathanjali Kadiya, Jim X Shen, Omnia A. Ismaiel, Vikram Roongta, James Waltrip, Morse Faria, Moucun Yuan
Publikováno v:
Journal of Applied Bioanalysis, Vol 6, Iss 3, Pp 145-163 (2020)
OBJECTIVES: To develop a LC-MS/MS method for simultaneous measurement of Tanespimycin (17-(allylamino)-17-demethoxygeldanamycin, BMS-722782, 17-AAG) and its active metabolite 17-(amino)-17-demethoxygeldanamycin (17-AG) in human plasma. METHODS: The s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89490290d941bd56326362e9b2643ce
https://doaj.org/article/533a927c36974707a0b7684265577bae
https://doaj.org/article/533a927c36974707a0b7684265577bae
Autor:
Morse Faria
Publikováno v:
Journal of Applied Bioanalysis, Vol 6, Iss 1, Pp 7-11 (2020)
Antibody-based biotherapeutics are the fastest growing category of therapeutics entering clinical studies [1]. The popularity is attributed to the high selectivity of these drugs which enhances their efficacy and reduces systemic toxicity, in turn, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a0b25d544693a1e30d344fa345e741
https://doaj.org/article/fe754a297c6844da917b606bf4dbbf20
https://doaj.org/article/fe754a297c6844da917b606bf4dbbf20
Publikováno v:
An Introduction to Bioanalysis of Biopharmaceuticals ISBN: 9783030971922
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8f6b88093322fca4b5437d99badaa1f
https://doi.org/10.1007/978-3-030-97193-9_3
https://doi.org/10.1007/978-3-030-97193-9_3
Publikováno v:
An Introduction to Bioanalysis of Biopharmaceuticals ISBN: 9783030971922
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b38f9b9d37c56814ba5412682bea30e
https://doi.org/10.1007/978-3-030-97193-9_6
https://doi.org/10.1007/978-3-030-97193-9_6
Autor:
William Mylott, Morse Faria, Diego F. Cortes, Lu Dai, Eric Wakshull, Jamie L Hicks, Junlong Shao, Surinder Kaur, Luna Liu, Cinzia Stella, Yanqiu Liu, Keyang Xu
Publikováno v:
Bioanalysis. 11(23)
Aim: To develop a sensitive hybrid immunoaffinity LC–MS/MS monkey serum assay to quantify multiple components of anti-Factor D; a complex PEGylated Fab biotherapeutic explored as a therapy for age-related macular degeneration. Materials & methods:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47687d298e3db2e808f4ea2332f9cabd
https://pubmed.ncbi.nlm.nih.gov/31701759
https://pubmed.ncbi.nlm.nih.gov/31701759
Autor:
Brandon Lam, Anton I. Rosenbaum, Meina Liang, William Mylott, Michael P Waldron, Eric Ma, Marlking G. Peay, Moucun Yuan, Morse Faria
Publikováno v:
Antibodies, Vol 8, Iss 1, p 11 (2019)
Antibodies
Volume 8
Issue 1
Antibodies
Volume 8
Issue 1
Bioanalysis of complex biotherapeutics, such as antibody-drug conjugates (ADCs), is challenging and requires multiple assays to describe their pharmacokinetic (PK) profiles. To enable exposure-safety and exposure-efficacy analyses, as well as to unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3e639f383a8b91c99fc240a5b7622f
https://pubmed.ncbi.nlm.nih.gov/31544817
https://pubmed.ncbi.nlm.nih.gov/31544817
Autor:
Matthew S. Halquist, Morse Faria
Publikováno v:
Calibration and Validation of Analytical Methods-A Sampling of Current Approaches
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458b99332c3cc61689bbb3612d9107a2
https://doi.org/10.5772/intechopen.75569
https://doi.org/10.5772/intechopen.75569
Autor:
Matthew S. Halquist, Morse Faria, Rand Jenkins, William Mylott, H. Thomas Karnes, Moucun Yuan
Publikováno v:
Journal of Chromatography B. 1001:156-168
Human osteopontin (hOPN) is a secreted plasma protein which is elevated in various cancers and is indicative of poor prognosis. Here we describe investigations involving an extended peptide internal standard to track an unstable signature peptide fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1053f49c84d3a91c888eef05064ddb0
https://doi.org/10.1016/j.jchromb.2015.05.040
https://doi.org/10.1016/j.jchromb.2015.05.040
Autor:
William Mylott, Matthew S. Halquist, Moucun Yuan, Morse Faria, H. Thomas Karnes, Rand Jenkins
Publikováno v:
Biomedical Chromatography. 29:1780-1782
A stable isotope-labeled signature peptide, whose sequence corresponds to the human osteopontin (hOPN) specific antibody epitope, was evaluated as an internal standard to compensate for immunocapture variability during quantification of hOPN by immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d346ccb032d56048adc87ee3cd618c13
https://doi.org/10.1002/bmc.3471
https://doi.org/10.1002/bmc.3471