The suboptimal fibrinolytic response in COVID-19 is dictated by high PAI-1

Autor: Whyte, CS, Simpson, M, Morrow, GB, Wallace, CA, Mentzer, AJ, Knight, JC, Shapiro, S, Curry, N, Bagot, CN, Watson, H, Cooper, JG, Mutch, NJ

Publikováno v: Journal of thrombosis and haemostasis : JTH. 20(10)

Background Severe COVID-19 disease is associated with thrombotic complications and extensive fibrin deposition. This study investigates whether the hemostatic complications in COVID-19 disease arise due to dysregulation of the fibrinolytic system. Me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2cc3c01f91f07a22ad6dfdaedd84a8
https://pubmed.ncbi.nlm.nih.gov/36123574

A novel method to quantify fibrin-fibrin and fibrin-α 2 -antiplasmin cross-links in thrombi formed from human trauma patient plasma.

Autor: Morrow GB; School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, United Kingdom; Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; Aberdeen Cardiovascular and Diabetes Centre, School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom. Electronic address: g.morrow1@rgu.ac.uk., Flannery S; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Charles PD; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Heilig R; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Feller T; Leeds Thrombosis Collective, Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom., McQuilten Z; Transfusion Research Unit, Monash University, Melbourne and Monash Health, Melbourne, Australia., Wake E; Trauma Service, Gold Coast University Hospital, University of Queensland, Southport, Queensland, Australia; School of Medicine, University of Queensland, Southport, Queensland, Australia., Ariens RAS; Leeds Thrombosis Collective, Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom., Winearls J; School of Medicine, University of Queensland, Southport, Queensland, Australia; Intensive Care Unit, Gold Coast University Hospital, Southport, Queensland, Australia; Australia and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia., Mutch NJ; Aberdeen Cardiovascular and Diabetes Centre, School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom., Fischer R; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Laffan MA; Centre for Haematology, Imperial College London, London, United Kingdom., Curry N; Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom; Oxford Haemophilia and Thrombosis Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.

Publikováno v: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2024 Jun; Vol. 22 (6), pp. 1758-1771. Date of Electronic Publication: 2024 Mar 09.

Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability.

Autor: Mitchell JL; Institute for Cardiovascular Research, University of Birmingham, Birmingham, UK., Little G; Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, UK., Bye AP; School of Pharmacy, University of Reading, Reading, UK., Gaspar RS; Heart Institute, University of Sao Paulo School of Medicine, Sao Paulo, Brazil., Unsworth AJ; Department of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK., Kriek N; Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, UK., Sage T; Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, UK., Stainer A; Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, UK., Sangowawa I; Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, UK., Morrow GB; Oxford University Hospitals NHS Foundation Trust, Blood Theme Oxford Biomedical Research Centre, Oxford, UK.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Bastos RN; Oxford Nanoimaging, Oxford, UK., Shapiro S; Oxford University Hospitals NHS Foundation Trust, Blood Theme Oxford Biomedical Research Centre, Oxford, UK.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Desborough MJR; Oxford University Hospitals NHS Foundation Trust, Blood Theme Oxford Biomedical Research Centre, Oxford, UK., Curry N; Oxford University Hospitals NHS Foundation Trust, Blood Theme Oxford Biomedical Research Centre, Oxford, UK.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Gibbins JM; Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, UK., Whyte CS; Aberdeen Cardiovascular & Diabetes Centre, School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK., Mutch NJ; Aberdeen Cardiovascular & Diabetes Centre, School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK., Jones CI; Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, UK.

Publikováno v: Research and practice in thrombosis and haemostasis [Res Pract Thromb Haemost] 2023 Jun 07; Vol. 7 (5), pp. 100200. Date of Electronic Publication: 2023 Jun 07 (Print Publication: 2023).

Removing plasmin from the equation - Something to chew on….

Autor: Morrow GB; Aberdeen Cardiovascular & Diabetes Centre, Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.; Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Mutch NJ; Aberdeen Cardiovascular & Diabetes Centre, Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.

Publikováno v: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2022 Feb; Vol. 20 (2), pp. 280-284. Date of Electronic Publication: 2021 Nov 23.

Fibrinogen Replacement Therapy for Traumatic Coagulopathy: Does the Fibrinogen Source Matter?

Autor: Morrow GB; Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.; Aberdeen Cardiovascular & Diabetes Centre, School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK., Carlier MSA; Aberdeen Cardiovascular & Diabetes Centre, School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK., Dasgupta S; Aberdeen Cardiovascular & Diabetes Centre, School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK., Craigen FB; Aberdeen Cardiovascular & Diabetes Centre, School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK., Mutch NJ; Aberdeen Cardiovascular & Diabetes Centre, School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK., Curry N; Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.; Oxford Haemophilia & Thrombosis Centre, NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford OX3 7LE, UK.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Feb 22; Vol. 22 (4). Date of Electronic Publication: 2021 Feb 22.