Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Morrissey, Michael M."'
Autor:
McMillan, Kirk, Adler, Marc, Auld, Douglas S., Baldwin, John J., Blasko, Eric, Browne, Leslie J., Chelsky, Daniel, Davey, David, Dolle, Ronald E., Eagen, Keith A., Erickson, Shawn, Feldman, Richard I., Glaser, Charles B., Mallari, Cornell, Morrissey, Michael M., Pan, Gonghua, Parkinson, John F., Phillips, Gary B., Polokoff, Mark A., Sigal, Nolan H., Vergona, Ronald, Whitlow, Marc, Young, Tish A., Devlin, James J.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2000 Feb . 97(4), 1506-1511.
Externí odkaz:
https://www.jstor.org/stable/121504
Autor:
Wilson, Alastair J., Réale, Denis, Clements, Michelle N., Morrissey, Michael M., Postma, Erik, Walling, Craig A., Kruuk, Loeske E. B., Nussey, Daniel H.
Publikováno v:
Journal of Animal Ecology, 2010 Jan 01. 79(1), 13-26.
Externí odkaz:
https://www.jstor.org/stable/40405900
Autor:
Kochanny, Monica J., Adler, Marc, Ewing, Janice, Griedel, Brian D., Ho, Elena, Karanjawala, Rushad, Lee, Wheeseong, Lentz, Dao, Liang, Amy M., Morrissey, Michael M., Phillips, Gary B., Post, Joseph, Sacchi, Karna L., Sakata, Steven T., Subramanyam, Babu, Vergona, Ron, Walters, Janette, White, Kathy A., Whitlow, Marc, Ye, Bin, Zhao, Zuchun, Shaw, Kenneth J.
Publikováno v:
In Bioorganic & Medicinal Chemistry 2007 15(5):2127-2146
Autor:
Ng, Howard P., Buckman, Brad O., Eagen, Keith A., Guilford, William J., Kochanny, Monica J., Mohan, Raju, Shaw, Kenneth J., Wu, Shung C., Lentz, Dao, Liang, Amy, Trinh, Lan, Ho, Elena, Smith, David, Subramanyam, Babu, Vergona, Ron, Walters, Janette, White, Kathy A., Sullivan, Mark E., Morrissey, Michael M., Phillips, Gary B.
Publikováno v:
In Bioorganic & Medicinal Chemistry 2002 10(3):657-666
Autor:
Dao Lentz, Marc Whitlow, Kenneth J. Shaw, Karna Lyn Sacchi, Sakata Steven T, Janette Walters, Kathy White, Joseph Post, Bin Ye, Wheeseong Lee, Kochanny Monica, Elena Ho, Amy Liang, Ron Vergona, Janice Ewing, Morrissey Michael M, Karanjawala Rushad E, Gary Phillips, Zuchun Zhao, Brian D. Griedel, Babu Subramanyam, Marc Adler
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:2127-2146
A series of thiophene-containing non-amidine factor Xa inhibitors is described. Simple methyl-substituted thiophene analogs were relatively weak inhibitors. However, introduction of hydrophilic substituents at C-4 or C-5 of the thiophene afforded inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b4b05420f1f0b4641803f66b53494f
https://doi.org/10.1016/j.bmc.2006.12.019
https://doi.org/10.1016/j.bmc.2006.12.019
Autor:
Sunil K. Koovakkat, Brad O. Buckman, Keith Eagen, Shung Wu, Ng Howard P, Raju Mohan, Wei Xu, Elena Ho, Lan Trinh, Babu Subramanyam, Meg McCarrick, Gary Phillips, Morrissey Michael M, Michael Pinkerton, William J. Guilford, Marc Whitlow, Amy Liang, David D. Davey
Publikováno v:
Journal of Medicinal Chemistry. 45:2484-2493
A novel series of diaryloxypyridines have been designed as selective nanomolar factor Xa (fXa) inhibitors for use as anticoagulants. In this paper, we describe our efforts to identify an additional interaction and a replacement for the distal amidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d684bc55897a8351d1b9be1346519e43
https://doi.org/10.1021/jm0200660
https://doi.org/10.1021/jm0200660
Autor:
Amy Liang, Ron Vergona, Keith Eagen, Janette Walters, David J. Smith, Kenneth J. Shaw, Ng Howard P, Elena Ho, Dao Lentz, Kathy White, Lan Trinh, Babu Subramanyam, Raju Mohan, Gary Phillips, Morrissey Michael M, Mark E. Sullivan, William J. Guilford, Brad O. Buckman, Shung C. Wu, Kochanny Monica
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:657-666
A novel series of triaryloxypyridines have been designed to inhibit factor Xa, a serine protease strategically located in the coagulation cascade. Inhibitor 5e has a K I against factor Xa of 0.12 nM and is greater than 8000- and 2000-fold selective o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61b28124500c42b131140d9bea08868f
https://doi.org/10.1016/s0968-0896(01)00338-8
https://doi.org/10.1016/s0968-0896(01)00338-8
Autor:
Marc Whitlow, Morrissey Michael M, Amy Liang, Brian D. Griedel, Jerry L. Dallas, Arnaiz Damian O, Joseph Post, Zuchun Zhao, Kenneth J. Shaw, Lan Trinh, Sakata Steven T
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:963-966
Inhibitors based on the benzimidazole scaffold showed subnanomolar potency against Factor Xa with 500–1000-fold selectivity against thrombin and 50–100-fold selectivity against trypsin. The 2-substituent on the benzimidazole ring had a strong imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eeb26d2396da2df3e284c79ad0b0fba
https://doi.org/10.1016/s0960-894x(00)00139-6
https://doi.org/10.1016/s0960-894x(00)00139-6
Autor:
Sunil K. Koovakkat, William J. Guilford, Wei Xu, Brad O. Buckman, Marian Seto, Brain Griedel, David R. Light, Morrissey Michael M, David D. Davey, Kenneth J. Shaw, Damain O. Arnaiz, Amy Liang, Gary Phillips, Zuchun Zhao, Raju Mohan, Marc Whitlow
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 55:1395-1404
Factor Xa is a serine protease which activates thrombin (factor IIa) and plays a key regulatory role in the blood-coagulation cascade. Factor Xa is, therefore, an important target for the design of anti-thrombotics. Both factor Xa and thrombin share
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014adafa43785dad6d1450599562bf33
https://doi.org/10.1107/s0907444999007350
https://doi.org/10.1107/s0907444999007350
Autor:
Sunil K. Koovakkaat, Margaret A. McCarrick, Kenneth J. Shaw, William J. Guilford, David R. Light, Morrissey Michael M, Jerry L. Dallas, Amy Liang
Publikováno v:
Journal of Medicinal Chemistry. 41:3551-3556
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::158954e611fa5cefa8c7038512a74502
https://doi.org/10.1021/jm980281+
https://doi.org/10.1021/jm980281+