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Small molecule induced STING degradation facilitated by the HECT ligase HERC4.

Autor: Mutlu M; Novartis BioMedical Research, Basel, Switzerland. merve.koch@novartis.com., Schmidt I; Novartis BioMedical Research, Basel, Switzerland., Morrison AI; Novartis BioMedical Research, Basel, Switzerland.; Amsterdam UMC location Vrije Universiteit Amsterdam, Molecular Cell Biology & Immunology, Amsterdam institute for Infection and Immunity, De Boelelaan, 1117, Amsterdam, The Netherlands., Goretzki B; Novartis BioMedical Research, Basel, Switzerland., Freuler F; Novartis BioMedical Research, Basel, Switzerland., Begue D; Novartis BioMedical Research, Basel, Switzerland., Simic O; Novartis BioMedical Research, Basel, Switzerland., Pythoud N; Novartis BioMedical Research, Basel, Switzerland., Ahrne E; Novartis BioMedical Research, Basel, Switzerland., Kapps S; Novartis BioMedical Research, Basel, Switzerland., Roest S; Novartis BioMedical Research, Basel, Switzerland., Bonenfant D; Novartis BioMedical Research, Basel, Switzerland.; Monte Rosa Therapeutics, Basel, Switzerland., Jeanpierre D; Novartis BioMedical Research, Basel, Switzerland., Tran TT; Novartis BioMedical Research, Basel, Switzerland., Maher R; Novartis BioMedical Research, Cambridge, MA, USA., An S; Novartis BioMedical Research, Cambridge, MA, USA., Rietsch A; Novartis BioMedical Research, Basel, Switzerland., Nigsch F; Novartis BioMedical Research, Basel, Switzerland., Hofmann A; Novartis BioMedical Research, Basel, Switzerland., Reece-Hoyes J; Novartis BioMedical Research, Cambridge, MA, USA.; Vector Biology, Cambridge, MA, USA., Parker CN; Novartis BioMedical Research, Basel, Switzerland., Guerini D; Novartis BioMedical Research, Basel, Switzerland.

Publikováno v: Nature communications [Nat Commun] 2024 May 29; Vol. 15 (1), pp. 4584. Date of Electronic Publication: 2024 May 29.

An Organotypic Human Lymph Node Model Reveals the Importance of Fibroblastic Reticular Cells for Dendritic Cell Function.

Autor: Morrison AI; Molecular Cell Biology and Immunology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands., Mikula AM; Molecular Cell Biology and Immunology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands., Spiekstra SW; Molecular Cell Biology and Immunology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands., de Kok M; Molecular Cell Biology and Immunology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands., Affandi AJ; Molecular Cell Biology and Immunology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Amsterdam, The Netherlands., Roest HP; Department of Surgery, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015GD, Rotterdam, The Netherlands., van der Laan LJW; Department of Surgery, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Dr. Molewaterplein 40, 3015GD, Rotterdam, The Netherlands., de Winde CM; Molecular Cell Biology and Immunology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Amsterdam, The Netherlands., Koning JJ; Molecular Cell Biology and Immunology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands., Gibbs S; Molecular Cell Biology and Immunology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands.; Department Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit, Amsterdam, The Netherlands., Mebius RE; Molecular Cell Biology and Immunology, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands. r.mebius@amsterdamumc.nl.; Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands. r.mebius@amsterdamumc.nl.

Publikováno v: Tissue engineering and regenerative medicine [Tissue Eng Regen Med] 2024 Apr; Vol. 21 (3), pp. 455-471. Date of Electronic Publication: 2023 Dec 19.