Výsledky vyhledávání - "Morris J. Robins"

Akademický článek

Model Substrate/Inactivation Reactions for MoaA and Ribonucleotide Reductases: Loss of Bromo, Chloro, or Tosylate Groups from C2 of 1,5-Dideoxyhomoribofuranoses upon Generation of an α-Oxy Radical at C3

Autor: Stanislaw F. Wnuk, Mukesh M. Mudgal, Ireneusz Nowak, Morris J. Robins

Publikováno v: Molecules, Vol 25, Iss 11, p 2539 (2020)

We report studies on radical-initiated fragmentations of model 1,5-dideoxyhomoribofuranose derivatives with bromo, chloro, and tosyloxy substituents on C2. The effects of stereochemical inversion at C2 were probed with the corresponding arabino epime

Externí odkaz: https://doaj.org/article/b144f46b308945dea84afcbc15e245fd

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Autor: Morris J. Robins, Ireneusz Nowak, Mukesh M. Mudgal, Stanislaw F. Wnuk

Publikováno v: Molecules, Vol 25, Iss 2539, p 2539 (2020)
Molecules
Volume 25
Issue 11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3241db90fcbcf189c97cab29cdc8e1b
https://doi.org/10.3390/molecules25112539

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Interaction of fused-pyrimidine nucleoside analogs with human concentrative nucleoside transporters: High-affinity inhibitors of human concentrative nucleoside transporter 1

Autor: Ireneusz Nowak, Carol E. Cass, James D. Young, Edward Karpinski, Delores Mowles, Vijaya L. Damaraju, Kyla M. Smith, Morris J. Robins

Publikováno v: Biochemical Pharmacology. 81:82-90

Human concentrative nucleoside transporters (hCNTs) mediate electrogenic secondary active transport of physiological nucleosides and nucleoside drugs into cells. Six fused-pyrimidine ribonucleosides and one 2'-deoxynucleoside were assessed for their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b69eea87905d7c62b8afb2c8104779
https://doi.org/10.1016/j.bcp.2010.09.009

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Autofluorescent fused-pyrimidine nucleosides: Synthesis and evaluation as permeants and inhibitors of human nucleoside transporters

Autor: Ireneusz Nowak, Carol E. Cass, James D. Young, Vijaya L. Damaraju, Morris J. Robins

Publikováno v: Collection of Czechoslovak Chemical Communications. 76:1395-1412

Nucleosides with an aromatic five-membered ring heterocycle (N, O, or S) fused at C4–C5 of pyrimidin-2-one were prepared by ring closures with 5-(alkyn-1-yl)pyrimidin-2-one intermediates, heterocyclic atom replacements, and ring closure with a 5-am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31114aaeed64c1055bc0fab94bacc300
https://doi.org/10.1135/cccc2011061

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Circular dichroism of nucleoside derivatives. VII. The electronic structure and spectra of some simple nucleoside derivatives

Autor: Daniel W. Miles, Michael W. Winkley, Morris J. Robins, Roland K. Robins, Henry Eyring, Warren H. Inskeep

Publikováno v: International Journal of Quantum Chemistry. 3:129-145

The electronic structures and spectra of some simple nucleoside derivatives with the formal structure of cytosine nucleoside are presented. The experimental spectroscopic information is obtained from the circular dichroism and absorption spectra. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a08549dab656f66291a5abfbb4b633a4
https://doi.org/10.1002/qua.560030718

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Synthesis and Biological Evaluation of 3,3-Difluoropyridine-2,4(1H,3H)-dione and 3-Deaza-3-fluorouracil Base and Nucleoside Derivatives

Autor: Erik De Clercq, Morris J. Robins, Jan Balzarini, Hong Yang, Matt A. Peterson, Karl Miranda

Publikováno v: Journal of Medicinal Chemistry. 52:3018-3027

New 3-deaza-3-halouracil nucleosides including 3-deaza-3-fluorouridine and its 2'-deoxy and arabino analogues have been prepared by fluorination of protected precursors. The resulting 3,3-difluoropyridine-2,4(1H,3H)-dione derivatives underwent pallad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0175bef4d2000d50992c86c5f2d451e
https://doi.org/10.1021/jm900203h

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Two Distinct Molecular Mechanisms Underlying Cytarabine Resistance in Human Leukemic Cells

Autor: Vijaya L. Damaraju, Philippe Gros, Morris J. Robins, Normand Groulx, Delores Mowles, Carol E. Cass, Yunshan Peng, Jie Cai

Publikováno v: Cancer Research. 68:2349-2357

To understand the mechanism of cellular resistance to the nucleoside analogue cytarabine (1-β-d-arabinofuranosylcytosine, AraC), two resistant derivatives of the human leukemic line CCRF-CEM were obtained by stepwise selection in different concentra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f09f1f460e7708f8ce549dfa001f0af
https://doi.org/10.1158/0008-5472.can-07-5528

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