Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Morris J Birnbaum"'
Autor:
Stephen E Flaherty III, Olivier Bezy, Brianna LaCarubba Paulhus, LouJin Song, Mary Piper, Jincheng Pang, Yoson Park, Shoh Asano, Yu-Chin Lien, John D Griffin, Andrew Robertson, Alan Opsahl, Dinesh Hirenallur Shanthappa, Youngwook Ahn, Evanthia Pashos, Rebecca A Simmons, Morris J Birnbaum, Zhidan Wu
Publikováno v:
eLife, Vol 12 (2024)
From a forward mutagenetic screen to discover mutations associated with obesity, we identified mutations in the Spag7 gene linked to metabolic dysfunction in mice. Here, we show that SPAG7 KO mice are born smaller and develop obesity and glucose into
Externí odkaz:
https://doaj.org/article/4c48137f953943ab9ab7d2ee4fda5031
Autor:
Robert H Newman, Jianfei Hu, Hee‐Sool Rho, Zhi Xie, Crystal Woodard, John Neiswinger, Christopher Cooper, Matthew Shirley, Hillary M Clark, Shaohui Hu, Woochang Hwang, Jun Seop Jeong, George Wu, Jimmy Lin, Xinxin Gao, Qiang Ni, Renu Goel, Shuli Xia, Hongkai Ji, Kevin N Dalby, Morris J Birnbaum, Philip A Cole, Stefan Knapp, Alexey G Ryazanov, Donald J Zack, Seth Blackshaw, Tony Pawson, Anne‐Claude Gingras, Stephen Desiderio, Akhilesh Pandey, Benjamin E Turk, Jin Zhang, Heng Zhu, Jiang Qian
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp 1-12 (2013)
Abstract The landscape of human phosphorylation networks has not been systematically explored, representing vast, unchartered territories within cellular signaling networks. Although a large number of in vivo phosphorylated residues have been identif
Externí odkaz:
https://doaj.org/article/6886196250374d4893d1b1be6feccd1e
Autor:
Daorong Feng, Dou Yeon Youn, Xiaoping Zhao, Yanguang Gao, William J Quinn, Alus M Xiaoli, Yan Sun, Morris J Birnbaum, Jeffrey E Pessin, Fajun Yang
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0126240 (2015)
In non-alcoholic fatty liver disease (NAFLD) and insulin resistance, hepatic de novo lipogenesis is often elevated, but the underlying mechanisms remain poorly understood. Recently, we show that CDK8 functions to suppress de novo lipogenesis. Here, w
Externí odkaz:
https://doaj.org/article/fd10902b45e346de95831630c0da7de9
Autor:
Marcus D Goncalves, Emidio E Pistilli, Anthony Balduzzi, Morris J Birnbaum, Jennifer Lachey, Tejvir S Khurana, Rexford S Ahima
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12707 (2010)
Akt is a critical mediator of developmental skeletal muscle growth. Treatment with a soluble ActRIIB fusion protein (ActRIIB-mFc) increases skeletal muscle mass and strength by inhibiting myostatin and related peptides. Recent in vitro studies have s
Externí odkaz:
https://doaj.org/article/bc21d1f9959d4ec69839f3aba6af646d
Autor:
Jose M. Garcia, Richard F. Dunne, Kristen Santiago, Lisa Martin, Morris J. Birnbaum, Jeffrey Crawford, Andrew E. Hendifar, Martin Kochanczyk, Cassadie Moravek, Doris Piccinin, Vincent Picozzi, Eric J. Roeland, Wendy K.D. Selig, Teresa A. Zimmers
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 2, Pp 1418-1425 (2022)
Externí odkaz:
https://doaj.org/article/1ddd00e55eb746dfa77b6814140d5643
Autor:
Morris J. Birnbaum, Mark A. Herman
Publikováno v:
Cell Metab
Excessive sugar consumption is increasingly considered as a contributor to the emerging epidemics of obesity and the associated cardiometabolic disease. Sugar is added to the diet in the form of sucrose or high-fructose corn syrup, both of which comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ab79aa0a141a57c7eed3d3b1a53a22
https://doi.org/10.1016/j.cmet.2021.09.010
https://doi.org/10.1016/j.cmet.2021.09.010
Publikováno v:
Nature Reviews Molecular Cell Biology. 22:751-771
Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in tissues — prominently in muscle, fat and liver — is one of the earliest manifestations of a constellation of human diseases that includes type 2 diabetes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::584c27c9d4c02d64dedb3f779f30bbc1
https://doi.org/10.1038/s41580-021-00390-6
https://doi.org/10.1038/s41580-021-00390-6
Autor:
Aditi R. Saxena, Juan P. Frias, Lisa S. Brown, Donal N. Gorman, Szilard Vasas, Nikolaos Tsamandouras, Morris J. Birnbaum
Publikováno v:
JAMA Network Open. 6:e2314493
ImportanceCurrently available glucagon-like peptide 1 receptor (GLP-1R) agonists for treating type 2 diabetes (T2D) are peptide agonists that require subcutaneous administration or strict fasting requirements before and after oral administration.Obje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bda7fa69b297e0a8ad736f97a1dbcf7b
https://doi.org/10.1001/jamanetworkopen.2023.14493
https://doi.org/10.1001/jamanetworkopen.2023.14493
Autor:
Jose M. Garcia, Richard F. Dunne, Kristen Santiago, Lisa Martin, Morris J. Birnbaum, Jeffrey Crawford, Andrew E. Hendifar, Martin Kochanczyk, Cassadie Moravek, Doris Piccinin, Vincent Picozzi, Eric J. Roeland, Wendy K.D. Selig, Teresa A. Zimmers
Publikováno v:
Journal of cachexia, sarcopenia and muscle. 13(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c7522ede64311e7171465d89dedf2e
https://pubmed.ncbi.nlm.nih.gov/35218313
https://pubmed.ncbi.nlm.nih.gov/35218313
Autor:
Morris J. Birnbaum, Kendra K. Bence
Publikováno v:
Molecular Metabolism, Vol 50, Iss, Pp 101143-(2021)
Molecular Metabolism
Molecular Metabolism
Background The incidence of non-alcoholic fatty liver disease (NAFLD) is rapidly increasing worldwide parallel to the global obesity epidemic. NAFLD encompasses a range of liver pathologies and most often originates from metabolically driven accumula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a3d2d265a6b492249d830f9b72bb3af
http://www.sciencedirect.com/science/article/pii/S2212877820302179
http://www.sciencedirect.com/science/article/pii/S2212877820302179