Zobrazeno 1 - 10
of 338
pro vyhledávání: '"Morris F White"'
Autor:
Simiao Xu, Yangyang Liu, Ruixiang Hu, Min Wang, Oliver Stöhr, Yibo Xiong, Liang Chen, Hong Kang, Lingyun Zheng, Songjie Cai, Li He, Cunchuan Wang, Kyle D Copps, Morris F White, Ji Miao
Publikováno v:
eLife, Vol 10 (2021)
The elucidation of the mechanisms whereby the liver maintains glucose homeostasis is crucial for the understanding of physiological and pathological states. Here, we show a novel role of hepatic transcriptional co-activator with PDZ-binding motif (TA
Externí odkaz:
https://doaj.org/article/7eb4adb4d92c49ffb5a35b4e5dddc79d
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71997 (2013)
Pyruvate dehydrogenase kinases (PDK1-4) play a critical role in the inhibition of the mitochondrial pyruvate dehydrogenase complex especially when blood glucose levels are low and pyruvate can be conserved for gluconeogenesis. Under diabetic conditio
Externí odkaz:
https://doaj.org/article/3b40615f220941d793df83f1fbc523f0
Autor:
Katsuya Tanabe, Zhonghao Liu, Satish Patel, Bradley W Doble, Lin Li, Corentin Cras-Méneur, Sara C Martinez, Cris M Welling, Morris F White, Ernesto Bernal-Mizrachi, James R Woodgett, M Alan Permutt
Publikováno v:
PLoS Biology, Vol 6, Iss 2, p e37 (2008)
Despite treatment with agents that enhance beta-cell function and insulin action, reduction in beta-cell mass is relentless in patients with insulin resistance and type 2 diabetes mellitus. Insulin resistance is characterized by impaired signaling th
Externí odkaz:
https://doaj.org/article/204fb8f76a4a4489839e941e516b46eb
Publikováno v:
Molecular Metabolism, Vol 71, Iss , Pp 101703- (2023)
Objective: Body weight change and obesity follow the variance of excess energy input balanced against tightly controlled EE (energy expenditure). Since insulin resistance can reduce energy storage, we investigated whether genetic disruption of hepati
Externí odkaz:
https://doaj.org/article/95d2d99252ed4ec6817c94084abdae15
Publikováno v:
Cell Metab
Non-alcoholic fatty liver disease (NAFLD) is not only a consequence of insulin resistance, but it is also an important cause of insulin resistance and major non-communicable diseases (NCDs). The close relationship of NAFLD with visceral obesity obscu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038fe642c2c4beb56d50b6339b724ecd
https://europepmc.org/articles/PMC10157895/
https://europepmc.org/articles/PMC10157895/
Autor:
Robert Wagner, Martin Heni, Konstantinos Kantartzis, Arvid Sandforth, Jürgen Machann, Fritz Schick, Andreas Peter, Louise Fritsche, Julia Szendrödi, Andreas F.H. Pfeiffer, Annette Schürmann, Matthias Blüher, Hans Hauner, Jochen Seissler, Stefan Bornstein, Michael Roden, Norbert Stefan, Andreas L. Birkenfeld, Morris F. White, Hans-Ulrich Häring, Andreas Fritsche
Publikováno v:
Diabetes 72, 362-366 (2023)
The objective of this work was to investigate whether impaired insulin secretion can be restored by lifestyle intervention in specific subphenotypes of prediabetes. One thousand forty-five participants from the Prediabetes Lifestyle Intervention Stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2172656fdbf99f94a72681f03e05b41f
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=66977
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=66977
Autor:
Liping Xie, Yanmei Yuan, Simiao Xu, Sijia Lu, Jinyang Gu, Yanping Wang, Yibing Wang, Xianjing Zhang, Suzhen Chen, Jian Li, Junxi Lu, Honglin Sun, Ruixiang Hu, Hailong Piao, Wen Wang, Cunchuan Wang, Jing Wang, Na Li, Morris F. White, Liu Han, Weiping Jia, Ji Miao, Junli Liu
Publikováno v:
Cell reports. 41(3)
Copper deficiency has emerged to be associated with various lipid metabolism diseases, including non-alcoholic fatty liver disease (NAFLD). However, the mechanisms that dictate the association between copper deficiency and metabolic diseases remain o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43788da110898ea9e920c86ea35b5251
https://pubmed.ncbi.nlm.nih.gov/36261001
https://pubmed.ncbi.nlm.nih.gov/36261001
Autor:
Jinghua Peng, Balamurugan Ramatchandirin, Yu Wang, Alexia Pearah, Kopperuncholan Namachivayam, Risa M. Wolf, Kimberley Steele, Krishnan MohanKumar, Liqing Yu, Shaodong Guo, Morris F. White, Akhil Maheshwari, Ling He
Publikováno v:
The Journal of biological chemistry. 298(3)
Inhibition of P300 acetyltransferase activity by specific inhibitor C646 has been shown to improve insulin signaling. However, the underlying molecular mechanism of this improvement remains unclear. In this study, we analyzed P300 levels of obese pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd62b19eba3d3a7728e663a6f7ebe876
https://pubmed.ncbi.nlm.nih.gov/35074429
https://pubmed.ncbi.nlm.nih.gov/35074429
Autor:
Kyle D. Copps, Songjie Cai, Ruixiang Hu, Morris F. White, Liang Chen, Min Wang, Hong Kang, Simiao Xu, Oliver Stöhr, Ji Miao, Cunchuan Wang, Li He, Yibo Xiong, Yangyang Liu, Lingyun Zheng
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
The elucidation of the mechanisms whereby the liver maintains glucose homeostasis is crucial for the understanding of physiological and pathological states. Here, we show a novel role of hepatic transcriptional co-activator with PDZ-binding motif (TA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e734ea4b54776007ad183df08a9039f
https://elifesciences.org/articles/57462
https://elifesciences.org/articles/57462
Autor:
Shuhei Ueda, Kun Yang, Takeshi Sakurai, Preben Bo Mortensen, Zui Narita, Nicola G. Cascella, Minae Niwa, Akiko Sumitomo, Hiroshi Yukitake, Akiko Taguchi, Yoichiro Takayanagi, Yasue Horiuchi, Koko Ishizuka, William W. Eaton, Thomas Munk Laursen, Akira Sawa, Morris F. White
Publikováno v:
Takayanagi, Y, Ishizuka, K, Laursen, T M, Yukitake, H, Yang, K, Cascella, N G, Ueda, S, Sumitomo, A, Narita, Z, Horiuchi, Y, Niwa, M, Taguchi, A, White, M F, Eaton, W W, Mortensen, P B, Sakurai, T & Sawa, A 2021, ' From population to neuron : exploring common mediators for metabolic problems and mental illnesses ', Molecular Psychiatry, vol. 26, no. 8, pp. 3931-3942 . https://doi.org/10.1038/s41380-020-00939-5
Molecular psychiatry
Molecular psychiatry
Major mental illnesses such as schizophrenia (SZ) and bipolar disorder (BP) frequently accompany metabolic conditions, but their relationship is still unclear, in particular at the mechanistic level. We implemented an approach of “from population t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca0d780ba066fbe14c7f80e6e705349
https://pure.au.dk/portal/da/publications/from-population-to-neuron(0def54ca-5452-4694-b1fb-2a11124ad078).html
https://pure.au.dk/portal/da/publications/from-population-to-neuron(0def54ca-5452-4694-b1fb-2a11124ad078).html