Zobrazeno 1 - 10
of 537
pro vyhledávání: '"Morris F White"'
Publikováno v:
Molecular Metabolism, Vol 71, Iss , Pp 101703- (2023)
Objective: Body weight change and obesity follow the variance of excess energy input balanced against tightly controlled EE (energy expenditure). Since insulin resistance can reduce energy storage, we investigated whether genetic disruption of hepati
Externí odkaz:
https://doaj.org/article/95d2d99252ed4ec6817c94084abdae15
Autor:
Chuanyan Wu, Yan Borné, Rui Gao, Maykel López Rodriguez, William C. Roell, Jonathan M. Wilson, Ajit Regmi, Cheng Luan, Dina Mansour Aly, Andreas Peter, Jürgen Machann, Harald Staiger, Andreas Fritsche, Andreas L. Birkenfeld, Rongya Tao, Robert Wagner, Mickaël Canouil, Mun-Gwan Hong, Jochen M. Schwenk, Emma Ahlqvist, Minna U. Kaikkonen, Peter Nilsson, Angela C. Shore, Faisel Khan, Andrea Natali, Olle Melander, Marju Orho-Melander, Jan Nilsson, Hans-Ulrich Häring, Erik Renström, Claes B. Wollheim, Gunnar Engström, Jianping Weng, Ewan R. Pearson, Paul W. Franks, Morris F. White, Kevin L. Duffin, Allan Arthur Vaag, Markku Laakso, Norbert Stefan, Leif Groop, Yang De Marinis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Follistatin promotes in type 2 diabetes (T2D) pathogenesis in model animals and is elevated in patients with T2D. Here the authors report that plasma follistatin associates with increased risk of incident T2D in two longitudinal cohorts, and show tha
Externí odkaz:
https://doaj.org/article/718976e80f5648f99659b5ea904f47e5
Autor:
Morris F. White, C. Ronald Kahn
Publikováno v:
Molecular Metabolism, Vol 52, Iss , Pp 101304- (2021)
The discovery of insulin 100 years ago and its application to the treatment of human disease in the years since have marked a major turning point in the history of medicine. The availability of purified insulin allowed for the establishment of its ph
Externí odkaz:
https://doaj.org/article/016dbb5cb10c4546b9518f9f34209566
Autor:
Simiao Xu, Yangyang Liu, Ruixiang Hu, Min Wang, Oliver Stöhr, Yibo Xiong, Liang Chen, Hong Kang, Lingyun Zheng, Songjie Cai, Li He, Cunchuan Wang, Kyle D Copps, Morris F White, Ji Miao
Publikováno v:
eLife, Vol 10 (2021)
The elucidation of the mechanisms whereby the liver maintains glucose homeostasis is crucial for the understanding of physiological and pathological states. Here, we show a novel role of hepatic transcriptional co-activator with PDZ-binding motif (TA
Externí odkaz:
https://doaj.org/article/7eb4adb4d92c49ffb5a35b4e5dddc79d
Publikováno v:
Cell Reports, Vol 34, Iss 12, Pp 108893- (2021)
Summary: Fgf21 (fibroblast growth factor 21) is a regulatory hepatokine that, in pharmacologic form, powerfully promotes weight loss and glucose homeostasis. Although “Fgf21 resistance” is inferred from higher plasma Fgf21 levels in insulin-resis
Externí odkaz:
https://doaj.org/article/59d3d218444147f78a799541e8a70b29
Autor:
Jia Cao, Jinghua Peng, Hongying An, Qiyi He, Tatiana Boronina, Shaodong Guo, Morris F. White, Philip A. Cole, Ling He
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Elevated plasma LPS levels have been associated with insulin resistance. Here Cao et al. show that LPS induces ER stress and P300 activity via the XBP1/IRE1 pathway. P300 acetylates IRS1/2 and inhibits its binding with the insulin receptor. The conse
Externí odkaz:
https://doaj.org/article/285554089e9548a3b4c4378a2f0a5555
Publikováno v:
Cell Metab
Non-alcoholic fatty liver disease (NAFLD) is not only a consequence of insulin resistance, but it is also an important cause of insulin resistance and major non-communicable diseases (NCDs). The close relationship of NAFLD with visceral obesity obscu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038fe642c2c4beb56d50b6339b724ecd
https://europepmc.org/articles/PMC10157895/
https://europepmc.org/articles/PMC10157895/
Autor:
Robert Wagner, Martin Heni, Konstantinos Kantartzis, Arvid Sandforth, Jürgen Machann, Fritz Schick, Andreas Peter, Louise Fritsche, Julia Szendrödi, Andreas F.H. Pfeiffer, Annette Schürmann, Matthias Blüher, Hans Hauner, Jochen Seissler, Stefan Bornstein, Michael Roden, Norbert Stefan, Andreas L. Birkenfeld, Morris F. White, Hans-Ulrich Häring, Andreas Fritsche
Publikováno v:
Diabetes 72, 362-366 (2023)
The objective of this work was to investigate whether impaired insulin secretion can be restored by lifestyle intervention in specific subphenotypes of prediabetes. One thousand forty-five participants from the Prediabetes Lifestyle Intervention Stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2172656fdbf99f94a72681f03e05b41f
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=66977
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=66977
Autor:
Jiyoon Ryu, Amanda K. Galan, Xiaoban Xin, Feng Dong, Muhammad A. Abdul-Ghani, Lijun Zhou, Changhua Wang, Cuiling Li, Bekke M. Holmes, Lauren B. Sloane, Steven N. Austad, Shaodong Guo, Nicolas Musi, Ralph A. DeFronzo, Chuxia Deng, Morris F. White, Feng Liu, Lily Q. Dong
Publikováno v:
Cell Reports, Vol 7, Iss 4, Pp 1227-1238 (2014)
Binding of insulin receptor substrate proteins 1 and 2 (IRS1/2) to the insulin receptor (IR) is essential for the regulation of insulin sensitivity and energy homeostasis. However, the mechanism of IRS1/2 recruitment to the IR remains elusive. Here,
Externí odkaz:
https://doaj.org/article/98b154f5d07a41fa93dfe06c7416fa4c
Autor:
Liping Xie, Yanmei Yuan, Simiao Xu, Sijia Lu, Jinyang Gu, Yanping Wang, Yibing Wang, Xianjing Zhang, Suzhen Chen, Jian Li, Junxi Lu, Honglin Sun, Ruixiang Hu, Hailong Piao, Wen Wang, Cunchuan Wang, Jing Wang, Na Li, Morris F. White, Liu Han, Weiping Jia, Ji Miao, Junli Liu
Publikováno v:
Cell reports. 41(3)
Copper deficiency has emerged to be associated with various lipid metabolism diseases, including non-alcoholic fatty liver disease (NAFLD). However, the mechanisms that dictate the association between copper deficiency and metabolic diseases remain o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43788da110898ea9e920c86ea35b5251
https://pubmed.ncbi.nlm.nih.gov/36261001
https://pubmed.ncbi.nlm.nih.gov/36261001