Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Morris E. Feldman"'
Autor:
Morris E Feldman, Beth Apsel, Aino Uotila, Robbie Loewith, Zachary A Knight, Davide Ruggero, Kevan M Shokat
Publikováno v:
PLoS Biology, Vol 7, Iss 2, p e38 (2009)
The mammalian target of rapamycin (mTOR) regulates cell growth and survival by integrating nutrient and hormonal signals. These signaling functions are distributed between at least two distinct mTOR protein complexes: mTORC1 and mTORC2. mTORC1 is sen
Externí odkaz:
https://doaj.org/article/698cb7ff5fb24dd29363fef1892083c8
Autor:
Animesh Chowdhury, Moshe Szyf, Matthew Suderman, Swati Srivastava, Moshit Lindzen, Cindy Körner, Moshe Oren, Stefan Wiemann, Kirti Shukla, Noa Furth, Yehoshua Enuka, Yoav Zaltsman, Mattia Lauriola, Renaud Massart, Yosef Yarden, Morris E. Feldman, Aldema Sas-Chen, Chiara A. Mazza, David Cheishvili
Publikováno v:
Nucleic Acids Research
Crosstalk between growth factors (GFs) and steroid hormones recurs in embryogenesis and is co-opted in pathology, but underlying mechanisms remain elusive. Our data from mammary cells imply that the crosstalk between the epidermal GF and glucocortico
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b669c4cfbfd56e5f8a8d300ad5131a0
https://doi.org/10.1093/nar/gkx865
https://doi.org/10.1093/nar/gkx865
Autor:
Aldema Sas-Chen, Yehoshua Enuka, Mattia Lauriola, Igor Ulitsky, Morris E. Feldman, Yosef Yarden
Publikováno v:
Nucleic Acids Research
Circular RNAs (circRNAs) are widespread circles of non-coding RNAs with largely unknown function. Because stimulation of mammary cells with the epidermal growth factor (EGF) leads to dynamic changes in the abundance of coding and non-coding RNA molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85a1b113a4d8d2916b0a42356ba946d
https://doi.org/10.1093/nar/gkv1367
https://doi.org/10.1093/nar/gkv1367
Autor:
Nicholas T. Ingolia, Matthew R. Janes, Andrew C. Hsieh, Craig R. Stumpf, Pingda Ren, Carly Christensen, Yi Liu, Kevan M. Shokat, Jonathan S. Weissman, Katti Jessen, Shunyou Wang, Michael Bonham, Christian Rommel, Michael C. Martin, Annie Sher, Evan Y. Shi, Davide Ruggero, Morris E. Feldman, Merritt Edlind
Publikováno v:
Nature. 485:55-61
The mammalian target of rapamycin (mTOR) kinase is a master regulator of protein synthesis that couples nutrient sensing to cell growth and cancer. However, the downstream translationally regulated nodes of gene expression that may direct cancer deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e571369edefcebdf1a9a0da786290bb
https://doi.org/10.1038/nature10912
https://doi.org/10.1038/nature10912
Autor:
Robert S. Warren, Kevan M. Shokat, Chloe E. Atreya, Morris E. Feldman, Emily K. Bergsland, Gregory S. Ducker
Publikováno v:
Investigational New Drugs. 30:2219-2225
ATP-competitive mammalian target of rapamycin (mTOR) inhibitors are in early phase clinical trials. These novel targeted agents, including PP242, are mechanistically distinct from the allosteric, partial mTOR inhibitor, rapamycin. The goal of this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6654a33cc1e30001e4ed628d434c5a2d
https://doi.org/10.1007/s10637-012-9793-y
https://doi.org/10.1007/s10637-012-9793-y
Autor:
Daniel Rauh, Matthew D. Simon, Ann E. Maris, Kevan M. Shokat, David E. Wemmer, Morris E. Feldman
Publikováno v:
ACS Chemical Biology. 1:755-760
The homeodomain (HD)-DNA interface has been conserved over 500 million years of evolution. Despite this conservation, we have successfully re-engineered the engrailed HD to specifically recognize an unnatural nucleotide using a phage display selectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c993051d897ec29f6f0aa8eb616b1d28
https://doi.org/10.1021/cb6003756
https://doi.org/10.1021/cb6003756
Publikováno v:
Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease ISBN: 9781493920525
Receptor tyrosine kinases, along with G protein-coupled receptors and the group of cytokine receptors, transmit a great majority of extracellular cues to the cytoplasm and nucleus of target cells. Here we focus on one subgroup of receptor tyrosine ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df326966cb863a5ecc6833de26304b16
https://doi.org/10.1007/978-1-4939-2053-2_6
https://doi.org/10.1007/978-1-4939-2053-2_6
Autor:
Morris E. Feldman, Yosef Yarden
Tumor progression can be understood as a collaborative effort of mutations and growth factors, which propels cell proliferation and matrix invasion, and also enables evasion of drug-induced apoptosis. Concentrating on EGFR, we discuss downstream sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d73d7433c1e2989186b532b6bb1553
https://europepmc.org/articles/PMC4096583/
https://europepmc.org/articles/PMC4096583/
Autor:
Morris E. Feldman, Lee Roth, Hadas Cohen-Dvashi, Moshit Lindzen, Fernando Schmitt, Rossella Solmi, Michal Sharon-Sevilla, Amit Zeisel, Stefan Wiemann, Yehoshua Enuka, Gabriele D'Uva, Mattia Lauriola, Nir Ben-Chetrit, Yosef Yarden, Nava Nevo, Eytan Domany, Silvia Carvalho, Alon Chen, Kirti Sharma, Merav Kedmi
Publikováno v:
Nature Communications
Signal transduction by receptor tyrosine kinases (RTKs) and nuclear receptors for steroid hormones is essential for body homeostasis, but the cross-talk between these receptor families is poorly understood. We observed that glucocorticoids inhibit si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1eea39b91af436769a83c456c777059
http://hdl.handle.net/11585/388179
http://hdl.handle.net/11585/388179
Autor:
Ian Mohr, Stuart M. Brown, Morris E. Feldman, Richard J. Roller, Uyanga Chuluunbaatar, Kevan M. Shokat
Publikováno v:
Genesdevelopment. 24(23)
All viruses require cellular ribosomes to translate their mRNAs. Viruses producing methyl-7 (m7) GTP-capped mRNAs, like Herpes Simplex Virus-1 (HSV-1), stimulate cap-dependent translation by activating mTORC1 to inhibit the translational repressor 4E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38dfd361a0ea26ccb3941366f553e02
https://pubmed.ncbi.nlm.nih.gov/21123644
https://pubmed.ncbi.nlm.nih.gov/21123644