Zobrazeno 1 - 10 of 53 pro vyhledávání: '"Morris D. Faiman"'
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N-Acetyl-S-(N,N-diethylcarbamoyl) cysteine in rat nucleus accumbens, medial prefrontal cortex, and in rat and human plasma after disulfiram administration
Autor: Robert D. Winefield, Swetha Kaul, Anthonius A. M. Heemskerk, Todd D. Williams, Michael J. Caspers, Morris D. Faiman, Elinore F. McCance-Katz, Craig E. Lunte, Thomas E. Prisinzano
Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 107:518-525
Disulfiram (DSF), a treatment for alcohol use disorders, has shown some clinical effectiveness in treating addiction to cocaine, nicotine, and pathological gambling. The mechanism of action of DSF for treating these addictions is unclear but it is un
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196d2261c5ed211c138c3fed92ab35bd
https://doi.org/10.1016/j.jpba.2015.01.036
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3
S-(N, N-diethylcarbamoyl)glutathione (carbamathione), a disulfiram metabolite and its effect on nucleus accumbens and prefrontal cortex dopamine, GABA, and glutamate: A microdialysis study
Autor: Swetha Kaul, Shaheen Azhar Latif, Craig E. Lunte, Todd D. Williams, Morris D. Faiman
Publikováno v: Neuropharmacology. 75:95-105
Disulfiram (DSF), used for the treatment of alcohol use disorders (AUDs) for over six decades, most recently has shown promise for treating cocaine dependence. Although DSF's mechanism of action in alcohol abuse is due to the inhibition of liver mito
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38b6bd09cade5b814658dbec5d229bf
https://doi.org/10.1016/j.neuropharm.2013.07.007
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4
LC-MS/MS method for the determination of carbamathione in human plasma
Autor: Anthonius A. M. Heemskerk, Joshua M. Woods, Elinore F. McCance-Katz, Leon van Haandel, Morris D. Faiman, John F. Stobaugh, Todd D. Williams
Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 54:799-806
Liquid chromatography-tandem mass spectrometry methodology is described for the determination of S-(N,N-diethylcarbamoyl)glutathione (carbamathione) in human plasma samples. Sample preparation consisted of a straightforward perchloric acid medicated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35dca9741a0fbf9ef2f1e2737c67497
https://doi.org/10.1016/j.jpba.2010.10.021
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5
LC–MS/MS determination of carbamathione in microdialysis samples from rat brain and plasma
Autor: Morris D. Faiman, Craig E. Lunte, Todd D. Williams, Swetha Kaul
Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 51:186-191
A selective liquid chromatography–tandem mass spectrometric (LC–MS/MS) method was developed for the determination of S-(N, N-diethylcarbamoyl) glutathione (carbamathione) in microdialysis samples from rat brain and plasma. S-(N, N-Diethylcarbamoy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f50d46f873f3a72fe49be235f4af2f
https://doi.org/10.1016/j.jpba.2009.07.026
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7
Identification of the Human P-450 Enzymes Responsible for the Sulfoxidation and Thiono-Oxidation of Diethyldithiocarbamate Methyl Ester: Role of P-450 Enzymes in Disulfiram Bioactivation
Autor: Morris D. Faiman, Andrew Parkinson, Ajay Madan
Publikováno v: Alcoholism: Clinical and Experimental Research. 22:1212-1219
Diethyldithiocarbamate methyl ester (DDTC-Me) is a precursorto the formation of S-methyl-N,N-diethylthiolcarbamate sulfoxide, the active metabolite proposed to be responsible for the alcohol deterrent effects of disulfiram. The present study investig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b07615daaa108b65a27b17e58f7f307
https://doi.org/10.1111/j.1530-0277.1998.tb03901.x
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8
Glutathione Carbamoylation with S-Methyl N,N-diethylthiolcarbamate Sulfoxide and Sulfone
Autor: Nagendra S. Ningaraj, John V. Schloss, Todd D. Williams, Morris D. Faiman
Publikováno v: Biochemical Pharmacology. 55:749-756
S -Methyl N , N -diethylthiolcarbamate sulfoxide (DETC-MeSO) and sulfone (DETC-MeSO 2 ) both inhibit rat liver low K m aldehyde dehydrogenase (ALDH 2 ) in vitro and in vivo (Nagendra et al ., Biochem Pharmacol 47: 1465–1467, 1994). DETC-MeSO has be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af98bd6fc982fae6b2c9593024f43aa3
https://doi.org/10.1016/s0006-2952(97)00513-3
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9
Carbamoylation of Brain Glutamate Receptors by a Disulfiram Metabolite
Autor: Xiangyue Newby, S. Ningaraj Nagendra, Kathleen Davis, Jang-Yen Wu, Morris D. Faiman, John V. Schloss
Publikováno v: Journal of Biological Chemistry. 272:24247-24251
S-Methyl-N,N-diethylthiolcarbamate sulfoxide (DETC-MeSO), a metabolite of the drug disulfiram, is a selective carbamoylating agent for sulfhydryl groups. Treatment of glutamate receptors isolated from mouse brain with DETC-MeSO blocks glutamate bindi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0b4aa2ee1a4f6431095bf79d1478cf
https://doi.org/10.1074/jbc.272.39.24247
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10
Inhibition of rat liver low Km aldehyde dehydrogenase by thiocarbamate herbicides
Autor: Morris D. Faiman, Bruch W. Hart
Publikováno v: Biochemical Pharmacology. 49:157-163
S-Methyl N,N-diethylthiolcarbamate (DETC-Me) is a metabolite formed during the bioactivation of disulfiram. The formation of its corresponding sulfoxide, S-methyl N,N-diethylthiolcarbamate sulfoxide (DETC-MeSO), from DETC-Me is required for low Km mi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5de1844f4b8ae3ae9ade9a0c6d33916
https://doi.org/10.1016/s0006-2952(94)00491-9
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