Nonfamilial, MPL S505N-Mutated Essential Thrombocythaemia.

Autor: Morrell, Ruth¹, Langabeer, Stephen E.¹ slangabeer@stjames.ie, Smyth, Liam¹, Perera, Meegahage¹, Crotty, Gerard^1,2

Publikováno v: Case Reports in Hematology. 2013, p1-4. 4p.

The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis

Autor: van Dijk, Marianne, Murphy, Eoin, Morrell, Ruth, O'Dwyer, Michael, Szegezdi, Eva, Samali, Afshin

Acute myeloid leukemia (AML) is an aggressive stem cell malignancy that is difficult to treat. There are limitations to the current treatment regimes especially after disease relapse, and therefore new therapeutic agents are urgently required which c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1513::5dd1855f8089b0d9036415d1ec8d273b
http://hdl.handle.net/10379/2585

The BH3 Mimetic, ABT-737, Overcomes Stromal-Mediated Pro-Survival Signals and Synergizes with PHA-767491, a Dual Cdc7/CDK9 Inhibitor, In Acute Myeloid Leukaemia

Autor: Morrell, Ruth C ^*, Szegezdi, Eva ^*, Halpin-McCormick, Anna ^*, Cawley, Karen ^*, Samali, Afshin ^*, O'Dwyer, Michael

Publikováno v: In Blood 19 November 2010 116(21):1841-1841

Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML.

Autor: O' Reilly E; Apoptosis Research Centre, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland., Dhami SPS; Apoptosis Research Centre, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland., Baev DV; Apoptosis Research Centre, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland., Ortutay C; Apoptosis Research Centre, School of Medicine, National University of Ireland Galway, Galway, Ireland.; HiDucator Ltd, Kangasala, Finland., Halpin-McCormick A; Apoptosis Research Centre, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland., Morrell R; Apoptosis Research Centre, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland., Santocanale C; Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland., Samali A; Apoptosis Research Centre, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland., Quinn J; Hematology, Beaumont Hospital, Dublin, Ireland., O'Dwyer ME; Apoptosis Research Centre, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland.; Apoptosis Research Centre, School of Medicine, National University of Ireland Galway, Galway, Ireland.; HiDucator Ltd, Kangasala, Finland., Szegezdi E; Apoptosis Research Centre, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland. eva.szegezdi@nuigalway.ie.

Publikováno v: Scientific reports [Sci Rep] 2018 Oct 25; Vol. 8 (1), pp. 15752. Date of Electronic Publication: 2018 Oct 25.