Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response

Autor: Sabina S Cosulich, Abigail Shea, Maurizio Callari, A. Dariush, Elena Provenzano, Martin O'Reilly, Carlos Caldas, Dimitra Georgopoulou, Agnese Giovannetti, Oscar M. Rueda, Gregory J. Hannon, Suet-Feung Chin, Giulia Lerda, Elham Esmaeilishirazifard, Alistair Martin, Violeta Serra, Fatime Qosaj, Wendy Greenwood, Dario Bressan, Larissa S. Carnevalli, Alejandra Bruna, H. Raza Ali, Gordon B. Mills

Publikováno v: Nature Communications
Nature communications, vol. 12, no. 1, pp. 1998
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

The heterogeneity of breast cancer plays a major role in drug response and resistance and has been extensively characterized at the genomic level. Here, a single-cell breast cancer mass cytometry (BCMC) panel is optimized to identify cell phenotypes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0712127e8562959156b1ae7983d647f

Long-Term Exposure to PFE-360 in the AAV-α-Synuclein Rat Model: Findings and Implications

Autor: Florence Sotty, Lassina Badolo, Michael Aagaard Andersen, Garrick Paul Smith, Kenneth Vielsted Christensen, Poul Henning Jensen, Ross Jeggo

Publikováno v: Andersen, M A, Sotty, F, Jensen, P H, Badolo, L, Jeggo, R, Smith, G P & Christensen, K V 2019, ' Long-Term Exposure to PFE-360 in the AAV-α-Synuclein Rat Model : Findings and Implications ', eNeuro, vol. 6, no. 6 . https://doi.org/10.1523/ENEURO.0453-18.2019
eNeuro

Parkinson’s disease (PD) is a progressive neurodegenerative disorder associated with impaired motor function and several non-motor symptoms, with no available disease modifying treatment. Intracellular accumulation of pathological α-synuclein incl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18e4a80ba326be9ee3a2715a50d4fb0
https://doi.org/10.1523/eneuro.0453-18.2019

Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes

Autor: John F. Cryan, Ted Dinan, Emilie Petit, John L. Waddington, Niamh Clarke, Orna Tighe, Lieve Desbonnet, Jeremy Walsh, Colm M. P. O’Tuathaigh, Gerard Clarke, Joseph A. Gogos, Claire O'Leary, Maria Karayiorgou

Publikováno v: The International Journal of Neuropsychopharmacology; Vol 15
O'Tuathaigh, C M P, Clarke, G, Walsh, J, Desbonnet, L, Petit, E, O'Leary, C, Tighe, O, Clarke, N, Karayiorgou, M, Gogos, J A, Dinan, T G, Cryan, J F & Waddington, J L 2012, ' Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes ', International Journal of Neuropsychopharmacology, vol. 15, no. 9, pp. 1331-1342 . https://doi.org/10.1017/S1461145711001581

Catechol-O-methyltransferase (COMT) is an important enzyme in the metabolism of dopamine and disturbance in dopamine function is proposed to be central to the pathogenesis of schizophrenia. Clinical epidemiological studies have indicated cannabis use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b0de7d85fe02fd6c5de74d9e5b2ff6

Caveolin-1-Mediated Expression and Secretion of Kallikrein 6 in Colon Cancer Cells

Autor: Natalia A. Ignatenko, Dora Cavallo-Medved, Eugene W. Gerner, Bonnie F. Sloane, Rebecca S. Henkhaus, Upal K. Basu Roy

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 2, Pp 140-148 (2008)
Biological Sciences Publications

Kallikreins are secreted proteases that may play a functional role and/or serve as a serum biomarker for the presence or progression of certain types of cancers. Kallikrein 6 (KLK6) has been shown to be upregulated in several types of cancers, includ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46bebb353bd258152b138cba27d86c59
http://www.sciencedirect.com/science/article/pii/S1476558608800607

Membrane Hyperpolarization Triggers Myogenin and Myocyte Enhancer Factor-2 Expression during Human Myoblast Differentiation

Autor: Stéphane König, Laurent Bernheim, Serge Arnaudeau, Nicolas Holzer, Charles R. Bader, Gael Potter, Valérie Hinard

Publikováno v: Journal of Biological Chemistry, Vol. 279, No 27 (2004) pp. 28187-28196

It is widely thought that myogenin is one of the earliest detectable markers of skeletal muscle differentiation. Here we show that, during human myoblast differentiation, an inward rectifier K(+) channel (Kir2.1) and its associated hyperpolarization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153e759543f0ed9d0f98a05e938bb861
https://doi.org/10.1074/jbc.m313932200