ABX464 Decreases the Total Human Immunodeficiency Virus (HIV) Reservoir and HIV Transcription Initiation in CD4+ T Cells From Antiretroviral Therapy-Suppressed Individuals Living With HIV

Autor: Moron-Lopez, S, Bernal, S, Wong, JK, Martinez-Picado, J, Yukl, SA

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 74, iss 11
Clinical Infectious Diseases
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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We evaluated the effect of ABX464 on the human immunodeficiency virus (HIV) reservoir and on the HIV transcription profile. ABX464 decreases total HIV DNA, may decrease intact HIV DNA, decreases HIV transcriptional initiation, and may decrease HIV tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::cb780114da4a6614dc3e2211beb525fd
https://escholarship.org/uc/item/1dr8j567

Transcriptional signature of resting-memory CD4 T cells differentiates spontaneous from treatment-induced HIV control

Autor: Garcia, M, Lopez-Fernandez, L, Minguez, P, Moron-Lopez, S, Restrepo, C, Navarrete-Munoz, MA, Lopez-Bernaldo, JC, Benguria, A, Garcia, MI, Cabello, A, Fernandez-Guerrero, M, De la Hera, FJ, Estrada, V, Barros, C, Martinez-Picado, J, Gorgolas, M, Benito, JM, Rallon, N

Publikováno v: JOURNAL OF MOLECULAR MEDICINE-JMM
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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The HIV reservoir is the main barrier to eradicating HIV infection, and resting memory CD4 T (Trm) cells are one of the most relevant cellular component harboring latent proviruses. This is the first study analyzing the transcriptional profile of Trm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::1c24b5024c1524efe64046139e9b1c90
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4694

Relationship between CCR5((WT/Delta 32)) heterozygosity and HIV-1 reservoir size in adolescents and young adults with perinatally acquired HIV-1 infection

Autor: Martinez-Bonet, M, Gonzalez-Serna, A, Clemente, MI, Moron-Lopez, S, Diaz, L, Navarro, M, Puertas, MC, Leal, M, Ruiz-Mateos, E, Martinez-Picado, J, Munoz-Fernandez, MA

Publikováno v: Clinical Microbiology and Infection
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname

Background: Several host factors contribute to human immunodeficiency virus (HIV) disease progression in the absence of combination antiretroviral therapy (cART). Among them, the CC-chemokine receptor 5 (CCR5) is known to be the main co-receptor used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::9872fd3c79356cffc9a8a4fb5cf173ea
https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6065

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