Aspergillus fumigatus Can Display Persistence to the Fungicidal Drug Voriconazole

Autor: Jennifer Scott, Clara Valero, Álvaro Mato-López, Ian J. Donaldson, Alejandra Roldán, Harry Chown, Norman Van Rhijn, Rebeca Lobo-Vega, Sara Gago, Takanori Furukawa, Alma Morogovsky, Ronen Ben Ami, Paul Bowyer, Nir Osherov, Thierry Fontaine, Gustavo H. Goldman, Emilia Mellado, Michael Bromley, Jorge Amich

Publikováno v: Microbiology Spectrum
Microbiology Spectrum, 2023, 11 (2), pp.e0477022. ⟨10.1128/spectrum.04770-22⟩
Scott, J, Valero, C, Mato-López, Á, Donaldson, I J, Roldán, A, Chown, H, Van Rhijn, N, Lobo-Vega, R, Gago, S, Furukawa, T, Morogovsky, A, Ben Ami, R, Bowyer, P, Osherov, N, Fontaine, T, Goldman, G H, Mellado, E, Bromley, M & Amich, J 2023, ' Aspergillus fumigatus Can Display Persistence to the Fungicidal Drug Voriconazole ', Microbiology spectrum . https://doi.org/10.1128/spectrum.04770-22

Aspergillus fumigatus is a filamentous fungus that can infect the lungs of patients with immunosuppression and/or underlying lung diseases. The mortality associated with chronic and invasive aspergillosis infections remain very high, despite availabi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ae1b85a8fe4ac169c04dfaa85ffdad
https://hal-pasteur.archives-ouvertes.fr/pasteur-04131659/file/spectrum.04770-22.pdf

Aspergillus fumigatuscan display persistence to the fungicidal drug voriconazole

Autor: Jennifer Scott, Clara Valero, Álvaro Mato-López, Ian J. Donaldson, Alejandra Roldán, Harry Chown, Norman Van Rhijn, Rebeca Lobo-Vega, Sara Gago, Takanori Furukawa, Alma Morogovsky, Ronen Ben Ami, Paul Bowyer, Nir Osherov, Thierry Fontaine, Gustavo H. Goldman, Emilia Mellado, Michael Bromley, Jorge Amich

Aspergillus fumigatusis a filamentous fungus that can infect the lungs of patients with immunosuppression and/or underlying lung-diseases. The mortality associated with chronic and invasive aspergillosis infections remain very high, despite availabil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f047801a61ab015e7674a55cac985633
https://doi.org/10.1101/2022.05.16.491816

Triazole-Resistant Aspergillus fumigatus in an Israeli Patient with Chronic Cavitary Pulmonary Aspergillosis Due to a Novel E306K Substitution in Hmg1

Autor: Nir Osherov, Ronen Ben-Ami, Alma Morogovsky, Mariana Handelman, Wei Liu

Publikováno v: Antimicrob Agents Chemother

Triazole resistance in the pathogenic mold Aspergillus fumigatus has increased worldwide, posing a growing therapeutic challenge. Recently, mutations in the 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase gene ( hmg1 ) have been associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b2a3256412460c118e8065377a3756
https://doi.org/10.1128/aac.01089-21