Grey Level Texture Features for Segmentation of Chromogenic Dye RNAscope From Breast Cancer Tissue

Autor: Davidson, Andrew, Morley-Bunker, Arthur, Wiggins, George, Walker, Logan, Harris, Gavin, Mukundan, Ramakrishnan, Investigators, kConFab

Chromogenic RNAscope dye and haematoxylin staining of cancer tissue facilitates diagnosis of the cancer type and subsequent treatment, and fits well into existing pathology workflows. However, manual quantification of the RNAscope transcripts (dots),

Externí odkaz: http://arxiv.org/abs/2401.15886

RNAscope compatibility with image analysis platforms for the quantification of tissue-based colorectal cancer biomarkers in archival formalin-fixed paraffin-embedded tissue

Autor: Morley-Bunker, Arthur E. ^*, Wiggins, George A.R., Currie, Margaret J., Morrin, Helen R., Whitehead, Martin R., Eglinton, Tim, Pearson, John, Walker, Logan C.

Publikováno v: In Acta Histochemica September 2021 123(6)

Novel and Annotated Long Noncoding RNAs Associated with Ischemia in the Human Heart

Autor: Anna P. Pilbrow, Simon C. Body, Allison L. Miller, Sebastian Schmeier, Martin I. Sigurdsson, Vicky A. Cameron, Josh Gorham, Wendy E. Sweet, Jonathan G. Seidman, Jochen D. Muehlschlegel, John F. Pearson, Arthur Morley-Bunker, Louis A. Saddic, Christine S. Moravec, Sary F. Aranki, Zoe Ward

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 11324, p 11324 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 21

Background: Long noncoding RNAs (lncRNAs) have been implicated in the pathogenesis of cardiovascular diseases. We aimed to identify novel lncRNAs associated with the early response to ischemia in the heart. Methods and Results: RNA sequencing data ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3260f61e20051bacaff111a4e396e0
https://www.mdpi.com/1422-0067/22/21/11324

Assessment of intra-tumoural colorectal cancer prognostic biomarkers using RNA in situ hybridisation

Autor: Helen Morrin, Martin Whitehead, Logan C. Walker, John F. Pearson, Arthur Morley-Bunker, Margaret J. Currie, Tim Eglinton

Publikováno v: Oncotarget

Genome-wide expression studies using microarrays and RNAseq have increased our understanding of colorectal cancer development. Translating potential gene biomarkers from these studies for clinical utility has typically relied on PCR-based technology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c757fc6ff86f3742ae400f404c5f6d0
http://europepmc.org/articles/PMC6402718

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