Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Moritz Widmaier"'
Autor:
Keith E. Steele, Tze Heng Tan, René Korn, Karma Dacosta, Charles Brown, Michael Kuziora, Johannes Zimmermann, Brian Laffin, Moritz Widmaier, Lorenz Rognoni, Ruben Cardenes, Katrin Schneider, Anmarie Boutrin, Philip Martin, Jiping Zha, Tobias Wiestler
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Background Immuno-oncology and cancer immunotherapies are areas of intense research. The numbers and locations of CD8+ tumor-infiltrating lymphocytes (TILs) are important measures of the immune response to cancer with prognostic, pharmacodyn
Externí odkaz:
https://doaj.org/article/7a113cf31f8c43b6a687bb8add920dde
Autor:
Marina Theodosiou, Moritz Widmaier, Ralph T Böttcher, Emanuel Rognoni, Maik Veelders, Mitasha Bharadwaj, Armin Lambacher, Katharina Austen, Daniel J Müller, Roy Zent, Reinhard Fässler
Publikováno v:
eLife, Vol 5 (2016)
Integrins require an activation step prior to ligand binding and signaling. How talin and kindlin contribute to these events in non-hematopoietic cells is poorly understood. Here we report that fibroblasts lacking either talin or kindlin failed to ac
Externí odkaz:
https://doaj.org/article/2cebde40050a4ecca02d34409a2d9edc
Autor:
Siegfried Ussar, Markus Moser, Moritz Widmaier, Emanuel Rognoni, Christian Harrer, Orsolya Genzel-Boroviczeny, Reinhard Fässler
Publikováno v:
PLoS Genetics, Vol 4, Iss 12, p e1000289 (2008)
Kindler Syndrome (KS), characterized by transient skin blistering followed by abnormal pigmentation, skin atrophy, and skin cancer, is caused by mutations in the FERMT1 gene. Although a few KS patients have been reported to also develop ulcerative co
Externí odkaz:
https://doaj.org/article/c5a7a75627f64daf8f166e82cea7360e
Autor:
Moritz Widmaier, Alexei Budco, Jill Walker, Marietta Scott, Farzad Sekhavati, Tobias Wiestler, Keith Steele, Katrin Schneider, Marlon Rebelatto, Felix J. Segerer, Craig Barker
Publikováno v:
Modern Pathology
Tumor programmed cell death ligand-1 (PD-L1) expression is a key biomarker to identify patients with non-small cell lung cancer who may have an enhanced response to anti-programmed cell death-1 (PD-1)/PD-L1 treatment. Such treatments are used in conj
Autor:
Sonja Althammer, Tobias Wiestler, Marie-Caroline Dieu-Nosjean, Scott A. Hammond, Koustubh Ranade, Diane Damotte, Brandon Higgs, Helene Kaplon, Marlon Rebelatto, Moritz Widmaier, Thomas Herz, Andreas Spitzmüller, Marco Alifano, Tze Heng Tan, Keith E Steele, Lorenz Rognoni, Guenter Schmidt
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1 (2019)
Journal for Immunotherapy of Cancer, 2017, 7, ⟨10.1186/s40425-019-0589-x⟩
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1 (2019)
Journal for Immunotherapy of Cancer, 2017, 7, ⟨10.1186/s40425-019-0589-x⟩
Background Immune checkpoint therapies (ICTs) targeting the programmed cell death-1 (PD1)/programmed cell death ligand-1 (PD-L1) pathway have improved outcomes for patients with non-small cell lung cancer (NSCLC), particularly those with high PD-L1 e
Autor:
Johannes Zimmermann, Keith Steele, Lorenz Rognoni, Moritz Widmaier, Katrin Schneider, Tobias Wiestler, Anmarie Boutrin, Brian Laffin, Jiping Zha, Tze Heng Tan, Karma Dacosta, Philip Martin, Charles Brown, René Korn, Ruben Cardenes, Michael Kuziora
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-14 (2018)
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-14 (2018)
Background Immuno-oncology and cancer immunotherapies are areas of intense research. The numbers and locations of CD8+ tumor-infiltrating lymphocytes (TILs) are important measures of the immune response to cancer with prognostic, pharmacodynamic, and
Publikováno v:
Archives in Cancer Research.
Autor:
Moritz Widmaier, Despoina Katsougkri, Joey Lai-Cheong, Reinhard Fässler, Ralph T. Böttcher, Daniel B. Rifkin, Raphael Ruppert, Emanuel Rognoni, Siegfried Ussar, Madis Jakobson, John A. McGrath
Publikováno v:
Nature medicine
Nature Medicine
Nature Medicine
Mutations in Kindlin-1 result in Kindler syndrome, which is marked by skin blistering, premature skin aging and increased risk for skin cancer. Reinhard Fassler and his colleagues have developed a new mouse model of the condition, revealing new cellu
Autor:
Roy Zent, Armin Lambacher, Marina Theodosiou, Reinhard Fässler, Daniel J. Müller, Emanuel Rognoni, K F Austen, Ralph T. Böttcher, Maik Veelders, Mitasha Bharadwaj, Moritz Widmaier
Publikováno v:
ELIFE
eLife
eLife, Vol 5 (2016)
eLife, 5
eLife
eLife, Vol 5 (2016)
eLife, 5
Integrins require an activation step prior to ligand binding and signaling. How talin and kindlin contribute to these events in non-hematopoietic cells is poorly understood. Here we report that fibroblasts lacking either talin or kindlin failed to ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5f180e5d527215592740050d2a07df
https://hdl.handle.net/11858/00-001M-0000-0029-CC02-F11858/00-001M-0000-0029-CC00-4
https://hdl.handle.net/11858/00-001M-0000-0029-CC02-F11858/00-001M-0000-0029-CC00-4
Autor:
Hui Yuan Tseng, Reinhard Fässler, Hannelore Meyer, Ralph T. Böttcher, Alexander Meves, Christopher Stremmel, Moritz Widmaier
Publikováno v:
Nature Cell Biology. 14:584-592
Integrin functions are controlled by regulating their affinity for ligand, and by the efficient recycling of intact integrins through endosomes. Here we demonstrate that the Kindlin-binding site in the β1-integrin cytoplasmic domain serves as a mole