Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Moritz Marcinowski"'
Autor:
Luca Santarelli, Eriene A. Youssef, Jorge A. Quiroz, Christian Czech, Paulo Fontoura, Randi J Hagerman, Elizabeth Berry-Kravis, Russell Kinch, Lothar Lindemann, Michael Rabbia, Dennis Deptula, Rachel Langland, Chin Y Wong, Moritz Marcinowski, David R Hessl, Philip Drewitt, Carsten Horn, Amy John
Publikováno v:
Neuropsychopharmacology
Preclinical data suggest that inhibition of the metabotropic glutamate receptor 5 (mGluR5) receptor might hold therapeutic benefits in Fragile X syndrome (FXS). Treatment of Fmr1 knockout mice with mGluR5-negative allosteric modulators (NAMs) has bee
Autor:
Nicolas Herbert, Armin Tgetgel, Eloisa Lopez-Calle, Thomas Fischer, Thorsten Brueckner, Moritz Marcinowski, Thomas Keller, Christoph Boehm, Juergen Spinke, Sascha Lutz, Pamela Espindola, Erik Beiersdorf
Publikováno v:
The Analyst. 142(22)
We present a novel fully integrated centrifugal microfluidic platform for highly sensitive immunoassays in point-of-care settings. The platform consists of a disposable cartridge containing structures for assay processing, a porous membrane and all d
Autor:
Johannes Elferich, Julia Behnke, Johannes Buchner, Moritz Marcinowski, Christine Seitz, Claudia Bello, Matthias J. Feige, Iris Antes, Mathias Rosam, Christian F. W. Becker
Publikováno v:
Journal of Molecular Biology. 425:466-474
Hsp70s are molecular chaperones involved in the folding and assembly of proteins. They recognize hydrophobic amino acid stretches in their substrate binding groove. However, a detailed understanding of substrate specificity is still missing. Here, we
Autor:
Nicolas Herbert, Armin Tgetgel, Sascha Lutz, Thorsten Brueckner, Christoph Boehm, Thomas Keller, Juergen Spinke, Moritz Marcinowski, Eloisa Lopez-Calle, Thomas Fischer, Juergen Klepp, Pamela Espindola, Alfons Nichtl
Publikováno v:
Clinical chemistry and laboratory medicine. 55(11)
BACKGROUND A multitude of troponin assays for the point-of-care (POC) have been developed showing a lack of analytical sensitivity and precision. We present a new platform solution for the high-sensitivity detection of cardiac troponin T (cTnT) in a
Autor:
Bjoern O. Schroeder, Zhihong Wu, Martin Schaller, Sandra Groscurth, Sabine Nuding, Jan Wehkamp, Eduard F. Stange, Johannes Buchner, Moritz Marcinowski, Julia Beisner
Publikováno v:
Nature. 469:419-423
Human epithelia are permanently challenged by bacteria and fungi, including commensal and pathogenic microbiota. In the gut, the fraction of strict anaerobes increases from proximal to distal, reaching 99% of bacterial species in the colon. At coloni
Publikováno v:
Journal of Molecular Biology. 370:674-686
The molecular chaperone Hsp104 is an AAA+ ATPase (ATPase associated with a variety of cellular activities) from yeast that catalyzes protein disaggregation. Using mutagenesis, we impaired nucleotide binding or hydrolysis in the two nucleotide-binding
The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins
Autor:
Janosch Hennig, Jirka Peschek, Julia Behnke, Michael Groll, Michael Sattler, Martin F. Flajnik, Moritz Marcinowski, Matthias J. Feige, Johannes Buchner, David Ausländer, Melissa Ann Gräwert, Caitlin D. Castro, Eva Maria Herold, Linda M. Hendershot
Publikováno v:
Proc. Natl. Acad. Sci. U.S.A. 111, 8155-8160 (2014)
Sharks and other cartilaginous fish are the phylogenetically oldest living organisms that rely on antibodies as part of their adaptive immune system. They produce the immunoglobulin new antigen receptor (IgNAR), a homodimeric heavy chain-only antibod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae3c107016bdd45b92bd0c63f97685d0
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=31294
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=31294
Autor:
Moritz Marcinowski, Danae Baerend, Johannes Buchner, Matthias Höller, Don C. Lamb, Matthias J. Feige
Publikováno v:
Nature structuralmolecular biology. 18(2)
The endoplasmic reticulum is the site of folding, assembly and quality control for proteins of the secretory pathway. The ATP-regulated Hsp70 chaperone BiP (heavy chain-binding protein), together with cochaperones, has important roles in all of these
Autor:
Sandra Groscurth, Horst Kessler, Matthias J. Feige, Yuichiro Shimizu, Linda M. Hendershot, Johannes Buchner, Moritz Marcinowski
A prerequisite for antibody secretion and function is the assembly into a defined quaternary structure, composed of two heavy and two light chains for IgG. Unassembled heavy chains are actively retained in the endoplasmic reticulum (ER) until they as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ae288a6136e09679158bf83c1289a1
https://europepmc.org/articles/PMC2908990/
https://europepmc.org/articles/PMC2908990/
Autor:
Moritz Marcinowski, Vincent Truffault, Emanuele Paci, Horst Kessler, Matthias J. Feige, Johannes Buchner, Zu Thur Yew, Sandra Groscurth
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 105(36)
Folding intermediates play a key role in defining protein folding and assembly pathways as well as those of misfolding and aggregation. Yet, due to their transient nature, they are poorly accessible to high-resolution techniques. Here, we made use of