Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Moritz Mall"'
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 3, Pp 144-161 (2024)
Abstract Precision in the establishment and maintenance of cellular identities is crucial for the development of multicellular organisms and requires tight regulation of gene expression. While extensive research has focused on understanding cell type
Externí odkaz:
https://doaj.org/article/4c8d1ce2da324abd8138a54f285ee6a3
Autor:
Changwen Wang, Meng Sun, Chunxuan Shao, Lisa Schlicker, Yue Zhuo, Yassin Harim, Tianping Peng, Weili Tian, Nadja Stöffler, Martin Schneider, Dominic Helm, Youjun Chu, Beibei Fu, Xiaoliang Jin, Jan-Philipp Mallm, Moritz Mall, Yonghe Wu, Almut Schulze, Hai-Kun Liu
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-21 (2024)
Abstract Recent advances in the genomics of glioblastoma (GBM) led to the introduction of molecular neuropathology but failed to translate into treatment improvement. This is largely attributed to the genetic and phenotypic heterogeneity of GBM, whic
Externí odkaz:
https://doaj.org/article/d63afc60087d40eba8fc806d9ff1af6b
Autor:
Markus Wöhr, Wendy M. Fong, Justyna A. Janas, Moritz Mall, Christian Thome, Madhuri Vangipuram, Lingjun Meng, Thomas C. Südhof, Marius Wernig
Publikováno v:
Molecular Autism, Vol 13, Iss 1, Pp 1-28 (2022)
Abstract Background The zinc finger domain containing transcription factor Myt1l is tightly associated with neuronal identity and is the only transcription factor known that is both neuron-specific and expressed in all neuronal subtypes. We identifie
Externí odkaz:
https://doaj.org/article/b7ff67c9372c446f969eb6ed5f640478
Autor:
Chongyuan Luo, Qian Yi Lee, Orly Wapinski, Rosa Castanon, Joseph R Nery, Moritz Mall, Michael S Kareta, Sean M Cullen, Margaret A Goodell, Howard Y Chang, Marius Wernig, Joseph R Ecker
Publikováno v:
eLife, Vol 8 (2019)
Direct reprogramming of fibroblasts to neurons induces widespread cellular and transcriptional reconfiguration. Here, we characterized global epigenomic changes during the direct reprogramming of mouse fibroblasts to neurons using whole-genome base-r
Externí odkaz:
https://doaj.org/article/9ddb88e6e2a54fc28cfcbc1f3cab0113
Autor:
Soham Chanda, Cheen Euong Ang, Jonathan Davila, ChangHui Pak, Moritz Mall, Qian Yi Lee, Henrik Ahlenius, Seung Woo Jung, Thomas C. Südhof, Marius Wernig
Publikováno v:
Stem Cell Reports, Vol 3, Iss 2, Pp 282-296 (2014)
Direct conversion of nonneural cells to functional neurons holds great promise for neurological disease modeling and regenerative medicine. We previously reported rapid reprogramming of mouse embryonic fibroblasts (MEFs) into mature induced neuronal
Externí odkaz:
https://doaj.org/article/0b12c0647c8849d4aed6bb170936af84
Autor:
Bettina Weigel, Jana F. Tegethoff, Sarah D. Grieder, Bryce Lim, Bhuvaneswari Nagarajan, Yu-Chao Liu, Jule Truberg, Dimitris Papageorgiou, Juan M. Adrian-Segarra, Laura K. Schmidt, Janina Kaspar, Eric Poisel, Elisa Heinzelmann, Manu Saraswat, Marleen Christ, Christian Arnold, Ignacio L. Ibarra, Joaquin Campos, Jeroen Krijgsveld, Hannah Monyer, Judith B. Zaugg, Claudio Acuna, Moritz Mall
Publikováno v:
Molecular Psychiatry.
MYT1L is an autism spectrum disorder (ASD)-associated transcription factor that is expressed in virtually all neurons throughout life. How MYT1L mutations cause neurological phenotypes and whether they can be targeted remains enigmatic. Here, we exam
Autor:
Justyna A. Janas, Lichao Zhang, Jacklyn H. Luu, Janos Demeter, Lingjun Meng, Samuele G. Marro, Moritz Mall, Nancie A. Mooney, Katie Schaukowitch, Yi Han Ng, Nan Yang, Yuhao Huang, Gernot Neumayer, Or Gozani, Joshua E. Elias, Peter K. Jackson, Marius Wernig
Publikováno v:
Molecular Cell. 82:4627-4646.e14
Cell lineage specification is accomplished by a concerted action of chromatin remodeling and tissue-specific transcription factors. However, the mechanisms that induce and maintain appropriate lineage-specific gene expression remain elusive. Here, we
Autor:
Anna Schönrock, Elisa Heinzelmann, Bianca Steffl, Engin Demirdizen, Ashwin Narayanan, Damir Krunic, Marion Bähr, Jong-Whi Park, Claudia Schmidt, Koray Özduman, M Necmettin Pamir, Wolfgang Wick, Felix Bestvater, Dieter Weichenhan, Christoph Plass, Julian Taranda, Moritz Mall, Şevin Turcan
Publikováno v:
Neuro Oncol
Background Glioblastoma (GBM) is an aggressive tumor that frequently exhibits gain of chromosome 7, loss of chromosome 10, and aberrantly activated receptor tyrosine kinase signaling pathways. Previously, we identified Mesenchyme Homeobox 2 (MEOX2),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf951fbefb8d31316b27733d0feb0dc
https://doi.org/10.1093/neuonc/noac110
https://doi.org/10.1093/neuonc/noac110
Autor:
Rui Li, Thomas C. Südhof, Kylesh S. Sharma, Juan M. Adrian-Segarra, Michael S. Kareta, Sarah Grieder, Bo Zhou, Howard Y. Chang, Moritz Mall, Qian Yi Lee, Katie Schaukowitch, Orly L. Wapinski, Marius Wernig, Cheen Euong Ang, Soham Chanda
Publikováno v:
Nature Cell Biology
The on-target pioneer factors Ascl1 and Myod1 are sequence-related but induce two developmentally unrelated lineages—that is, neuronal and muscle identities, respectively. It is unclear how these two basic helix–loop–helix (bHLH) factors mediat
Autor:
Claudia Schmidt, Damir Krunic, Ashwin Narayanan, Wolfgang Wick, Elisa Heinzelmann, Marion Bähr, Moritz Mall, Dieter Weichenhan, Sevin Turcan, M. Necmettin Pamir, Jong-Whi Park, Bianca Steffl, Christoph Plass, Koray Özduman, Julian Taranda, Anna Schönrock, Felix Bestvater
Glioblastoma (GBM) is an aggressive tumor that frequently exhibits gain of chromosome 7, loss of chromosome 10 and aberrantly activated receptor tyrosine kinase signaling pathways. Here, we identify mesenchyme homeobox 2 (MEOX2) on chromosome 7 with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3998e83f0895b9d466a3c8e81cb2f7b
https://doi.org/10.1101/2021.08.24.457477
https://doi.org/10.1101/2021.08.24.457477