Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Moritz M Hettich"'
1
Akademický článek
The anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complex.
Autor: Moritz M Hettich, Frank Matthes, Devon P Ryan, Nadine Griesche, Susanne Schröder, Stephanie Dorn, Sybille Krauβ, Dan Ehninger
Publikováno v: PLoS ONE, Vol 9, Iss 7, p e102420 (2014)
Alzheimer's disease (AD), the most common form of dementia in the elderly, is characterized by two neuropathological hallmarks: senile plaques, which are composed of Aβ peptides, and neurofibrillary tangles, which are composed of hyperphosphorylated
Externí odkaz: https://doaj.org/article/42649d0e94c24c4ca876da763496d3f4
Zobrazit plný text záznamu
2
Akademický článek
Limited Effects of an eIF2αS51A Allele on Neurological Impairments in the 5xFAD Mouse Model of Alzheimer’s Disease
Autor: Katharina Paesler, Kan Xie, Moritz M. Hettich, Magdalena E. Siwek, Devon P. Ryan, Susanne Schröder, Anna Papazoglou, Karl Broich, Ralf Müller, Astrid Trog, Alexander Garthe, Gerd Kempermann, Marco Weiergräber, Dan Ehninger
Publikováno v: Neural Plasticity, Vol 2015 (2015)
Alzheimer’s disease (AD) has been associated with increased phosphorylation of the translation initiation factor 2α (eIF2α) at serine 51. Increased phosphorylation of eIF2α alters translational control and may thereby have adverse effects on syn
Externí odkaz: https://doaj.org/article/c5b79f79f07d4a578ff7dbe2ab6b1af9
Zobrazit plný text záznamu
3
Akademický článek
Adult-Onset Fluoxetine Treatment Does Not Improve Behavioral Impairments and May Have Adverse Effects on the Ts65Dn Mouse Model of Down Syndrome
Autor: Markus Heinen, Moritz M. Hettich, Devon P. Ryan, Susanne Schnell, Katharina Paesler, Dan Ehninger
Publikováno v: Neural Plasticity, Vol 2012 (2012)
Down syndrome is caused by triplication of chromosome 21 and is associated with neurocognitive phenotypes ranging from severe intellectual disability to various patterns of more selective neuropsychological deficits, including memory impairments. In
Externí odkaz: https://doaj.org/article/58976ced1e084ea6a9b3cca7d8890f9a
Zobrazit plný text záznamu
4
Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex
Autor: Sybille Krauß, Karen L. Posey, Stephanie Weber, Susann Schweiger, Frank Matthes, Rainer Schneider, Dan Ehninger, Sandra Pfurtscheller, Eva Kickstein, Moritz M. Hettich
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific reports 7(1), 13753 (2017). doi:10.1038/s41598-017-12974-4
Scientific Reports
The formation of paired helical filaments (PHF), which are composed of hyperphosphorylated Tau protein dissociating from microtubules, is one of the pathological hallmarks of Alzheimer’s disease (AD) and other tauopathies. The most important phosph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225f73d6601be10421fe5c4afb3819c4
https://doi.org/10.1038/s41598-017-12974-4
Zobrazit plný text záznamu
5
Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis
Autor: Diana Flores-Dominguez, Alina Dagane, Judith Schilling, Nelli Blank, Sybille Krauss, Ina Vorberg, Erich E. Wanker, Frank Matthes, Moritz M. Hettich, Hanna Wolf, Dan Ehninger, Gunnar Dittmar, Stephanie Weber, Alexander Buntru, Thomas Wiglenda
Publikováno v: Cell Death Discovery
Cell death discovery 4(1), 4 (2018). doi:10.1038/s41420-017-0003-8
Cell Death Discovery, Vol 4, Iss 1, Pp 1-19 (2018)
Alzheimer’s disease (AD) is characterized by two neuropathological hallmarks: senile plaques, which are composed of amyloid-β (Aβ) peptides, and neurofibrillary tangles, which are composed of hyperphosphorylated tau protein. Aβ peptides are deri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41aed3ff0e3a0bfa0e0ed3090c0528a
https://pubmed.ncbi.nlm.nih.gov/29531801
Zobrazit plný text záznamu
7
Limited Effects of an eIF2αS51A Allele on Neurological Impairments in the 5xFAD Mouse Model of Alzheimer’s Disease
Autor: Alexander Garthe, Astrid Trog, Magdalena Elisabeth Siwek, Anna Papazoglou, Devon Ryan, Marco Weiergräber, Dan Ehninger, Ralf Müller, Gerd Kempermann, Katharina Paesler, Karl Broich, Moritz M. Hettich, Susanne Schröder, Kan Xie
Publikováno v: Neural Plasticity
Neural plasticity 2015, 1-14 (2015). doi:10.1155/2015/825157
Neural Plasticity, Vol 2015 (2015)
Alzheimer’s disease (AD) has been associated with increased phosphorylation of the translation initiation factor 2α(eIF2α) at serine 51. Increased phosphorylation of eIF2αalters translational control and may thereby have adverse effects on synap
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9e0b8c4119aebed41fb05160d214a7
Zobrazit plný text záznamu
8
The anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complex
Autor: Devon Ryan, Dan Ehninger, Nadine Griesche, Moritz M. Hettich, Stephanie Dorn, Frank Matthes, Susanne Schröder, Sybille Krauß
Publikováno v: PLoS ONE, Vol 9, Iss 7, p e102420 (2014)
PLOS ONE 9(7), e102420 (2014). doi:10.1371/journal.pone.0102420
PLoS ONE
Alzheimer’s disease (AD), the most common form of dementia in the elderly, is characterized by two neuropathological hallmarks: senile plaques, which are composed of Aβ peptides, and neurofibrillary tangles, which are composed of hyperphosphorylat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4771a072d5c69d70888a4a45114c9d4b
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25025689/?tool=EBI
Zobrazit plný text záznamu
10
Adult-Onset Fluoxetine Treatment Does Not Improve Behavioral Impairments and May Have Adverse Effects on the Ts65Dn Mouse Model of Down Syndrome
Autor: Susanne Schnell, Devon Ryan, Katharina Paesler, Markus Heinen, Moritz M. Hettich, Dan Ehninger
Publikováno v: Neural Plasticity
Neural Plasticity, Vol 2012 (2012)
Neural plasticity 2012, 1-10 (2012). doi:10.1155/2012/467251
Down syndrome is caused by triplication of chromosome 21 and is associated with neurocognitive phenotypes ranging from severe intellectual disability to various patterns of more selective neuropsychological deficits, including memory impairments. In
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e87d1be4e7818908f037e8bcda22d8
http://europepmc.org/articles/PMC3405721
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje