Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Moritz Horn"'
Autor:
Xinquan Zhang, Tinglin Pang, Haifeng Zhang, Moritz Horn, Georg Michlits, Matheus Dyczynski, Liqun Zhang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Natural compounds constitute a major resource for the development of medicines for multiple diseases. While many natural compounds show strong biological activity, the mechanisms that confer clinical benefits are often elusive and have been
Externí odkaz:
https://doaj.org/article/7de794bd1a30468da587b6089a931fdc
Autor:
Vanessa Monteil, Hyesoo Kwon, Lijo John, Cristiano Salata, Gustav Jonsson, Sabine U. Vorrink, Sofia Appelberg, Sonia Youhanna, Matheus Dyczynski, Alexandra Leopoldi, Nicole Leeb, Jennifer Volz, Astrid Hagelkruys, Max J. Kellner, Stéphanie Devignot, Georg Michlits, Michelle Foong-Sobis, Friedemann Weber, Volker M. Lauschke, Moritz Horn, Heinz Feldmann, Ulrich Elling, Josef M. Penninger, Ali Mirazimi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Marburg and Ebola filoviruses are two of the deadliest infectious agents and several outbreaks have occurred in the last decades. Although several receptors and co-receptors have been reported for Ebola virus, key host factors remain to be e
Externí odkaz:
https://doaj.org/article/138c2c1cad6c485e9bafa12b9c5adf5c
Autor:
Jasmin Taubenschmid‐Stowers, Michael Orthofer, Anna Laemmerer, Christian Krauditsch, Marianna Rózsová, Christian Studer, Daniela Lötsch, Johannes Gojo, Lisa Gabler, Matheus Dyczynski, Thomas Efferth, Astrid Hagelkruys, Georg Widhalm, Andreas Peyrl, Sabine Spiegl‐Kreinecker, Dominic Hoepfner, Shan Bian, Walter Berger, Juergen A Knoblich, Ulrich Elling, Moritz Horn, Josef M Penninger
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 3, Pp n/a-n/a (2023)
Abstract The natural compound Artemisinin is the most widely used antimalarial drug worldwide. Based on its cytotoxicity, it is also used for anticancer therapy. Artemisinin and its derivates are endoperoxides that damage proteins in eukaryotic cells
Externí odkaz:
https://doaj.org/article/7735106cb6194b64bd51f140f2fd01c5
Autor:
Virginia Kroef, Sabine Ruegenberg, Moritz Horn, Kira Allmeroth, Lena Ebert, Seyma Bozkus, Stephan Miethe, Ulrich Elling, Bernhard Schermer, Ulrich Baumann, Martin Sebastian Denzel
Publikováno v:
eLife, Vol 11 (2022)
The hexosamine biosynthetic pathway (HBP) produces the essential metabolite UDP-GlcNAc and plays a key role in metabolism, health, and aging. The HBP is controlled by its rate-limiting enzyme glutamine fructose-6-phosphate amidotransferase (GFPT/GFAT
Externí odkaz:
https://doaj.org/article/96486b935c874ee9b30a3e6f9c3aa11f
Autor:
Sabine Ruegenberg, Moritz Horn, Christian Pichlo, Kira Allmeroth, Ulrich Baumann, Martin S. Denzel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Mutations in the hexosamine pathway key enzyme glutamine fructose-6-phosphate amidotransferase (GFAT-1) improve protein quality control and extend C. elegans lifespan. Here the authors present the crystal structures of full-length human GFAT-1 alone
Externí odkaz:
https://doaj.org/article/e59e6a5f14a34fdf901be6fbcaf41cc6
Autor:
Vanessa Monteil, Matheus Dyczynski, Volker M Lauschke, Hyesoo Kwon, Gerald Wirnsberger, Sonia Youhanna, Haibo Zhang, Arthur S Slutsky, Carmen Hurtado del Pozo, Moritz Horn, Nuria Montserrat, Josef M Penninger, Ali Mirazimi
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 1, Pp n/a-n/a (2021)
Abstract There is a critical need for safe and effective drugs for COVID‐19. Only remdesivir has received authorization for COVID‐19 and has been shown to improve outcomes but not decrease mortality. However, the dose of remdesivir is limited by
Externí odkaz:
https://doaj.org/article/07998970104b4c38b5f25f0f58d1b221
Autor:
Moritz Horn, Sarah I. Denzel, Balaji Srinivasan, Kira Allmeroth, Isabelle Schiffer, Vignesh Karthikaisamy, Stephan Miethe, Peter Breuer, Adam Antebi, Martin S. Denzel
Publikováno v:
iScience, Vol 23, Iss 3, Pp - (2020)
Summary: Activation of the hexosamine pathway (HP) through gain-of-function mutations in its rate-limiting enzyme glutamine fructose-6-phosphate amidotransferase (GFAT-1) ameliorates proteotoxicity and increases lifespan in Caenorhabditis elegans. He
Externí odkaz:
https://doaj.org/article/087241d9385f4ca39e67a6ce52c26b55
Autor:
Jakob Voß, Moritz Horn
Publikováno v:
Code4Lib Journal, Iss 26 (2014)
This article provides an introduction to the JavaScript framework AngularJS and specific AngularJS modules for accessing library services. It shows how information such as search suggestions, additional links, and availability can be embedded in any
Externí odkaz:
https://doaj.org/article/904fd760a7d040feb8f097455847ba6b
Autor:
Martina Schildt, Moritz Horn
Publikováno v:
ABI Technik. 42:55-63
Zusammenfassung FOLIO ist ein Bibliotheksmanagementsystem zur Organisation aller ressourcenbezogenen Geschäftsabläufe, insbesondere zur Verwaltung elektronischer Ressourcen und zur Weiterverarbeitung ihrer Metadaten in Drittsystemen. Die GOKb ist e
Autor:
Michael Orthofer, Jasmin Taubenschmid-Stowers, Marianna Rozsova, Anna Laemmerer, Daniela Loetsch, Johannes Gojo, Andreas Peyrl, Walter Berger, Ullrich Elling, Moritz Horn, Josef M. Penninger
Publikováno v:
Cancer Research. 83:3951-3951
Forward genetic screens have revolutionized the field of target discovery, target deconvolution, and target validation, particularly in the cancer field. However, most approaches are limited to the interrogation of non-essential factors and identify