Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Moritz F. Eissmann"'
Autor:
Anne Huber, Amr H. Allam, Christine Dijkstra, Stefan Thiem, Jennifer Huynh, Ashleigh R. Poh, Joshua Konecnik, Saumya P. Jacob, Rita Busuttil, Yang Liao, David Chisanga, Wei Shi, Mariah G. Alorro, Stephen Forrow, Daniele V.F. Tauriello, Eduard Batlle, Alex Boussioutas, David S. Williams, Michael Buchert, Matthias Ernst, Moritz F. Eissmann
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114616- (2024)
Summary: Although aberrant activation of the KRAS and PI3K pathway alongside TP53 mutations account for frequent aberrations in human gastric cancers, neither the sequence nor the individual contributions of these mutations have been clarified. Here,
Externí odkaz:
https://doaj.org/article/bcbb4c19d532433d8228119f5febdeda
Autor:
Ryan N. O’Keefe, Annalisa L. E. Carli, David Baloyan, David Chisanga, Wei Shi, Shoukat Afshar-Sterle, Moritz F. Eissmann, Ashleigh R. Poh, Bhupinder Pal, Cyril Seillet, Richard M. Locksley, Matthias Ernst, Michael Buchert
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Although gastric cancer is a leading cause of cancer-related deaths, systemic treatment strategies remain scarce. Here, we report the pro-tumorigenic properties of the crosstalk between intestinal tuft cells and type 2 innate lymphoid cells
Externí odkaz:
https://doaj.org/article/df512f7f46214cfb976d0ea791783501
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102076- (2023)
Summary: Gene-of-interest knockout organoids present a powerful and versatile research tool to study a gene’s effects on many biological and pathological processes. Here, we present a straightforward and broadly applicable protocol to generate gene
Externí odkaz:
https://doaj.org/article/bc73b869b51e4abf956de7a3425b3324
Autor:
Riley J. Morrow, Amr H. Allam, Josh Konecnik, David Baloyan, Christine Dijkstra, Moritz F. Eissmann, Saumya P. Jacob, Megan O’Brien, Ashleigh R. Poh, Matthias Ernst
Publikováno v:
Cells, Vol 11, Iss 24, p 4104 (2022)
Aberrant expression of the oncoprotein c-Myc (Myc) is frequently observed in solid tumors and is associated with reduced overall survival. In addition to well-recognized cancer cell-intrinsic roles of Myc, studies have also suggested tumor-promoting
Externí odkaz:
https://doaj.org/article/e07f1bdc3de4487b93a8929e1842ee67
Autor:
Moritz F. Eissmann, Christine Dijkstra, Andrew Jarnicki, Toby Phesse, Jamina Brunnberg, Ashleigh R. Poh, Nima Etemadi, Evelyn Tsantikos, Stefan Thiem, Nicholas D. Huntington, Margaret L. Hibbs, Alex Boussioutas, Michele A. Grimbaldeston, Michael Buchert, Robert J. J. O’Donoghue, Frederick Masson, Matthias Ernst
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Mast cells within the tumor microenvironment have controversial roles. Here, the authors show, using genetic mouse models, that in gastric cancer, mast cells at the periphery of the tumors are activated via cancer cell produced-IL33 and promote tumor
Externí odkaz:
https://doaj.org/article/358dfe59c0ac41659d29059d99a2f0be
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The Interleukin (IL-)1 family IL33 is best known for eliciting type 2 immune responses by stimulating mast cells (MCs), regulatory T-cells (Tregs), innate lymphoid cells (ILCs) and other immune cells. MCs and IL33 provide critical control of immunolo
Externí odkaz:
https://doaj.org/article/fd56a7b6916f473e9c474d2bfa700a9e
Autor:
Matthias Ernst, Ashwini L. Chand, Frederick Masson, Louis Boon, Moritz F. Eissmann, Pathum Thilakasiri, Adam C. Parslow, David S. Williams, Lokman Pang, Mariah Alorro, Shoukat Afshar-Sterle, Megan O'Brien, Wei Shi, David Chisanga, David Baloyan, Jennifer Huynh
IL11 is a member of the IL6 family of cytokines and signals through its cognate receptor subunits, IL11RA and glycoprotein 130 (GP130), to elicit biological responses via the JAK/STAT signaling pathway. IL11 contributes to cancer progression by promo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d0223f3118b1931ca3497342246e47
https://doi.org/10.1158/2326-6066.c.6550444.v1
https://doi.org/10.1158/2326-6066.c.6550444.v1
Autor:
Matthias Ernst, Robert J.J. O'Donoghue, Fiona J. Pixley, Tracy L. Putoczki, Clifford A. Lowell, Megan O'Brien, Lachlan Whitehead, Michael W. Murrey, Louis Boon, David Baloyan, Ashwini L. Chand, Moritz F. Eissmann, Amy R. Dwyer, Ashleigh R. Poh
Increased HCK activity in BMDMs supports tumor cell invasion in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d0176964ef16bdad891da122661b61
https://doi.org/10.1158/2326-6066.22542897.v1
https://doi.org/10.1158/2326-6066.22542897.v1
Autor:
Matthias Ernst, Robert J.J. O'Donoghue, Fiona J. Pixley, Tracy L. Putoczki, Clifford A. Lowell, Megan O'Brien, Lachlan Whitehead, Michael W. Murrey, Louis Boon, David Baloyan, Ashwini L. Chand, Moritz F. Eissmann, Amy R. Dwyer, Ashleigh R. Poh
Persistent activation of the latent transcription factor STAT3 is observed in gastric tumor epithelial and immune cells and is associated with a poor patient prognosis. Although targeting STAT3-activating upstream kinases offers therapeutically viabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a55fcba6c2fa63a18d36a4da65f2571
https://doi.org/10.1158/2326-6066.c.6550074.v1
https://doi.org/10.1158/2326-6066.c.6550074.v1
Autor:
Matthias Ernst, Robert J.J. O'Donoghue, Fiona J. Pixley, Tracy L. Putoczki, Clifford A. Lowell, Megan O'Brien, Lachlan Whitehead, Michael W. Murrey, Louis Boon, David Baloyan, Ashwini L. Chand, Moritz F. Eissmann, Amy R. Dwyer, Ashleigh R. Poh
Constitutive HCK activity in bone marrow-derived cells enhances STAT3 activation in tumors and tumor-associated macrophages.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a74ec4c16f52870e618866ba0774ef
https://doi.org/10.1158/2326-6066.22542900.v1
https://doi.org/10.1158/2326-6066.22542900.v1